Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Aisling C. McMahon"'
Autor:
Amelia K. Fotheringham, Samantha M. Solon-Biet, Helle Bielefeldt-Ohmann, Domenica A. McCarthy, Aisling C. McMahon, Kari Ruohonen, Isaac Li, Mitchell A. Sullivan, Rani O. Whiddett, Danielle J. Borg, Victoria C. Cogger, William O. Ballard, Nigel Turner, Richard G. Melvin, David Raubenheimer, David G. Le Couteur, Stephen J. Simpson, Josephine M. Forbes
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103308- (2021)
Summary: The kidneys balance many byproducts of the metabolism of dietary components. Previous studies examining dietary effects on kidney health are generally of short duration and manipulate a single macronutrient. Here, kidney function and structu
Externí odkaz:
https://doaj.org/article/379150e318a640cc9c9a9ea0ac822fba
Autor:
Samantha M. Solon-Biet, Sarah J. Mitchell, Sean C.P. Coogan, Victoria C. Cogger, Rahul Gokarn, Aisling C. McMahon, David Raubenheimer, Rafael de Cabo, Stephen J. Simpson, David G. Le Couteur
Publikováno v:
Cell Reports, Vol 11, Iss 10, Pp 1529-1534 (2015)
Both caloric restriction (CR) and low-protein, high-carbohydrate (LPHC) ad-libitum-fed diets increase lifespan and improve metabolic parameters such as insulin, glucose, and blood lipids. Severe CR, however, is unsustainable for most people; therefor
Externí odkaz:
https://doaj.org/article/5e413f3b03974ecc8c1d89c5aa4daf48
Autor:
Danielle J. Borg, Stephen J. Simpson, Samantha M. Solon-Biet, Josephine M. Forbes, David Raubenheimer, Mitchell A. Sullivan, Richard G. Melvin, William O. Ballard, Isaac T. S. Li, Aisling C. McMahon, Rani O. Whiddett, Kari Ruohonen, Nigel Turner, Amelia K. Fotheringham, Domenica A. McCarthy, Victoria C. Cogger, Helle Bielefeldt-Ohmann, David G. Le Couteur
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103308-(2021)
iScience
iScience
Summary The kidneys balance many byproducts of the metabolism of dietary components. Previous studies examining dietary effects on kidney health are generally of short duration and manipulate a single macronutrient. Here, kidney function and structur
Autor:
Ze-Yan Yu, Ju-Chiat Tan, Aisling C McMahon, Siiri E Iismaa, Xiao-Hui Xiao, Scott H Kesteven, Melissa E Reichelt, Marion C Mohl, Nicola J Smith, Diane Fatkin, David Allen, Stewart I Head, Robert M Graham, Michael P Feneley
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99024 (2014)
To determine the mechanisms by which the α1A-adrenergic receptor (AR) regulates cardiac contractility.We reported previously that transgenic mice with cardiac-restricted α1A-AR overexpression (α1A-TG) exhibit enhanced contractility but not hypertr
Externí odkaz:
https://doaj.org/article/7cf2975340e84d309efedf580a689349
Autor:
Samantha M. Solon-Biet, J. William O. Ballard, Gregory J. Cooney, Devin Wahl, Victoria C. Cogger, Rahul Gokarn, David Raubenheimer, Margaret J. Morris, Neil A. Youngson, David G. Le Couteur, Aisling C. McMahon, Stephen J. Simpson
Publikováno v:
The Journals of Gerontology: Series A. 73:446-449
Macronutrients and dietary energy influence aging, age-related health, and life span. Reduction in telomere length has been proposed as one mechanism for aging. Therefore, this study investigated the effects of varying ratios of dietary macronutrient
Autor:
Jibran A Wali, Samantha M. Solon-Biet, Rahul Gokarn, David E. James, David G. Le Couteur, Stephen J. Simpson, Fleur Ponton, Tamara Pulpitel, Christopher D. Morrison, Kirsty A Walters, Victoria C. Cogger, Marika Heblinski, Arthur D. Conigrave, Kari Ruohonen, David Raubenheimer, James R. Krycer, Aisling C. McMahon, Jessica Durrant-Whyte, Devin Wahl, Alessandra Warren
Publikováno v:
Cell Metabolism. 24:555-565
Fibroblast growth factor 21 (FGF21) is the first known endocrine signal activated by protein restriction. Although FGF21 is robustly elevated in low-protein environments, increased FGF21 is also seen in various other contexts such as fasting, overfee
Autor:
Paul K. Witting, Farjaneh Hossain, XiaoSuo Wang, Anu Shanu, Aisling C. McMahon, Hyun Bo Kim, Ludwig K. Groebler
Publikováno v:
Free radical biologymedicine. 129
Autor:
James R. Mitchell, Sarah J. Mitchell, Christopher Hine, Aisling C. McMahon, Victoria C. Cogger, Rafael de Cabo, Devin Wahl, David G. Le Couteur, Rahul Gokarn, David Raubenheimer, Gregory J. Cooney, Samantha M. Solon-Biet, Stephen J. Simpson
Nutrition influences both hepatic function and aging, but mechanisms are poorly understood. Here, the effects of lifelong, ad libitum-fed diets varying in macronutrients and energy on hepatic gene expression were studied. Gene expression was measured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763f7f5f3ceda39944ed7d6cb646da93
https://europepmc.org/articles/PMC6454416/
https://europepmc.org/articles/PMC6454416/
Autor:
Sarah J. Mitchell, Rafael de Cabo, Rahul Gokarn, Sean C. P. Coogan, Samantha M. Solon-Biet, David Raubenheimer, Aisling C. McMahon, David G. Le Couteur, Stephen J. Simpson, Victoria C. Cogger
Publikováno v:
Cell Reports, Vol 11, Iss 10, Pp 1529-1534 (2015)
SummaryBoth caloric restriction (CR) and low-protein, high-carbohydrate (LPHC) ad-libitum-fed diets increase lifespan and improve metabolic parameters such as insulin, glucose, and blood lipids. Severe CR, however, is unsustainable for most people; t
Autor:
J. W. O. Ballard, David J. Handelsman, Ulla Simanainen, David Raubenheimer, Kirsty A Walters, David G. Le Couteur, Aisling C. McMahon, Kari Ruohonen, Samantha M. Solon-Biet, Stephen J. Simpson
Publikováno v:
Proceedings of the National Academy of Sciences. 112:3481-3486
In invertebrates, reproductive output and lifespan are profoundly impacted by dietary macronutrient balance, with these traits achieving their maxima on different diet compositions, giving the appearance of a resource-based tradeoff between reproduct