Výsledky vyhledávání - "Aishwarya Shevade"

Akademický článek

Mitochondrial Voltage-Dependent Anion Channel Protein Por1 Positively Regulates the Nuclear Localization of Saccharomyces cerevisiae AMP-Activated Protein Kinase

Autor: Aishwarya Shevade, Vera Strogolova, Marianna Orlova, Chay Teng Yeo, Sergei Kuchin

Publikováno v: mSphere, Vol 3, Iss 1 (2018)

ABSTRACT Snf1 protein kinase of the yeast Saccharomyces cerevisiae is a member of the highly conserved eukaryotic AMP-activated protein kinase (AMPK) family, which is involved in regulating responses to energy limitation. Under conditions of carbon/e

Externí odkaz: https://doaj.org/article/0cc2f76e3e2e48a795875557fb03fcd5

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High-Yield Recombinant Adeno-Associated Virus Production Using a Novel Transfection Reagent

Autor: Louis Coplan, Zhe Zhang, Nicole Ragone, John Reeves, Audrey Rodriguez, Aishwarya Shevade, Hanne Bak, Andrew Tustian

Recombinant adeno-associated viruses are a promising gene therapy, with several therapeutics on the market in the United States. As we continue to industrialize manufacturing of these viral vectors, we strive to improve productivity and yield. To thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7009ba71bd5df67caffb055887176e9a
https://doi.org/10.22541/au.167415846.68479152/v1

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A conformational switch driven by phosphorylation regulates the activity of the evolutionarily conserved SNARE Ykt6

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 12, pp. e2016730118

Significance Ykt6 is a conserved SNARE that plays critical roles along multiple vesicular pathways. To achieve its function, Ykt6 cycles between the cytosol and membrane-bound compartments through reversible lipidation. The mechanism that regulates t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4bd0e23041df6f7c5e6861afa9cb4ac
http://europepmc.org/articles/PMC8000380

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A conformational switch driven by phosphorylation regulates Ykt6 activity in macroautophagy

Autor: Daayun Chung, Damian B. van Rossum, Gabriela Caraveo, Mykola Dergai, Jeffrey N. Savas, Shivani Agarwal, Sergei Kuchin, Sofia Zaichick, Kaitlyn McGrath, Aishwarya Shevade, Dirk Fasshauer

Membrane fusion, an essential process in all eukaryotes, is driven by SNARE proteins. Ykt6 is an essential SNARE that plays critical roles throughout the secretory, endocytic, and autophagy pathways. Ykt6 activity is thought to be regulated by a conf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5929a0b9be39ebfc934fe12227f2e91e

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Mitochondrial Porin Por1 and Its Homolog Por2 Contribute to the Positive Control of Snf1 Protein Kinase in Saccharomyces cerevisiae

Autor: Vera Strogolova, Marianna Orlova, Sergei Kuchin, Aishwarya Shevade

Publikováno v: Eukaryotic Cell. 11:1568-1572

Saccharomyces cerevisiae Snf1 is a member of the conserved Snf1/AMP-activated protein kinase (Snf1/AMPK) family involved in regulating responses to energy limitation, which is detected by mechanisms that include sensing adenine nucleotides. Mitochond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc69696a8650b3a363f61de74f33e384
https://doi.org/10.1128/ec.00127-12

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Quaternary structure of the yeast pheromone receptor Ste2 in living cells

Autor: Gabriel Biener, Aishwarya Shevade, Koki Yokoi, Michael R. Stoneman, Sergei Kuchin, Joel D. Paprocki, Valerica Raicu

Publikováno v: Biochimica et biophysica acta. Biomembranes. 1859(9 Pt)

Transmembrane proteins known as G protein-coupled receptors (GPCRs) have been shown to form functional homo- or hetero-oligomeric complexes, although agreement has been slow to emerge on whether homo-oligomerization plays functional roles. Here we in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e536a9a383302ced4801ffab197e301a
https://pubmed.ncbi.nlm.nih.gov/27993568

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Springing into Action: Reg2 Negatively Regulates Snf1 Protein Kinase and Facilitates Recovery from Prolonged Glucose Starvation in Saccharomyces cerevisiae

Autor: LaKisha Barrett, Aishwarya Shevade, Marcin Maziarz, Sergei Kuchin

Publikováno v: Applied and environmental microbiology. 82(13)

Glucose is the preferred carbon source for the yeast Saccharomyces cerevisiae . Glucose limitation activates Snf1 protein kinase, a key regulator of energy homeostasis that promotes utilization of alternative carbon sources and enforces energy conser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86637576bd7f9c912393ccd95d87fe26
https://pubmed.ncbi.nlm.nih.gov/27107116

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