Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Aishwarya P. Deshpande"'
Autor:
Urmimala Basu, Hajin Kim, Jiayu Shen, Laura Johnson, Kalyan Das, Seung-Won Lee, Aishwarya P. Deshpande, Hayoon Cho, Byeong Kwon Sohn, Smita S. Patel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Controlling efficiency and fidelity in the early stage of mitochondrial DNA transcription is crucial for regulating cellular energy metabolism. Conformational transitions of the transcription initiation complex must be central for such control, but h
Autor:
Aishwarya P. Deshpande, Hajin Kim, Jiayu Shen, Smita S. Patel, Byeong-Kwon Sohn, Hayoon Cho, Seung-Won Lee, Urmimala Basu
Publikováno v:
Nucleic Acids Research
Mitochondrial RNA polymerases depend on initiation factors, such as TFB2M in humans and Mtf1 in yeast Saccharomyces cerevisiae, for promoter-specific transcription. These factors drive the melting of promoter DNA, but how they support RNA priming and
Autor:
Jiayu Shen, Hajin Kim, Smita S. Patel, Aishwarya P. Deshpande, Urmimala Basu, Byeong-Kwon Sohn, Seung-Won Lee, Hayoon Cho
Controlling efficiency and fidelity in the early stage of mitochondrial DNA transcription is crucial for regulating cellular energy metabolism. Studies of bacteriophage and bacterial systems have revealed that transcription occurs through a series of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6db8f28b17a79b9187c28af2fc746e
Publikováno v:
Nucleic Acids Research
Deshpande, AP; & Collins, K. (2018). Mechanisms of template handling and pseudoknot folding in human telomerase and their manipulation to expand the sequence repertoire of processive repeat synthesis. Nucleic Acids Research, 46(15), 7886-7901. doi: 10.1093/nar/gky601. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/4xm4s4qv
Nucleic acids research, vol 46, iss 15
Deshpande, AP; & Collins, K. (2018). Mechanisms of template handling and pseudoknot folding in human telomerase and their manipulation to expand the sequence repertoire of processive repeat synthesis. Nucleic Acids Research, 46(15), 7886-7901. doi: 10.1093/nar/gky601. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/4xm4s4qv
Nucleic acids research, vol 46, iss 15
© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research. Telomerase adds telomeric repeats to chromosome ends by processive copying of a template within the telomerase RNA bound to telomerase reverse transcript
Telomerase restores chromosome-capping telomeric repeats lost with each round of genome replication by DNA-templated DNA polymerases. The telomerase reverse transcriptase (TERT) N-terminal (TEN) domain is a peripheral, telomerase-specific, processivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6107684e1daadca4697a87d5b426f6f5
https://doi.org/10.1101/621573
https://doi.org/10.1101/621573
Autor:
Aishwarya P. Deshpande, Ramanagouda R-Bhojappa, Y. Whitney Yin, Divya Nandakumar, Kevin D. Raney, Aparna Ramachandran, Guo-Qing Tang, Smita S. Patel, Thomas P. Lucas
Publikováno v:
Journal of Biological Chemistry. 291:16828-16839
Primases use single-stranded (ss) DNAs as templates to synthesize short oligoribonucleotide primers that initiate lagging strand DNA synthesis or reprime DNA synthesis after replication fork collapse, but the origin of this activity in the mitochondr
Autor:
Aishwarya P. Deshpande, Smita S. Patel
Publikováno v:
Nucleic Acids Research
Mitochondrial promoters of Saccharomyces cerevisiae share a conserved −8 to +1 sequence with +1+2 AA, AG or AT initiation sequence, which dictates the efficiency of transcription initiation by the mitochondrial RNA polymerase Rpo41 and its initiati
Autor:
Smita S. Patel, Aishwarya P. Deshpande
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1819:930-938
Mitochondria are the major supplier of cellular energy in the form of ATP. Defects in normal ATP production due to dysfunctions in mitochondrial gene expression are responsible for many mitochondrial and aging related disorders. Mitochondria carry th
Autor:
Aishwarya P. Deshpande, Smita S. Patel
Publikováno v:
The FASEB Journal. 27
Publikováno v:
The Journal of biological chemistry. 286(18)
Transcription of the yeast (Saccharomyces cerevisiae) mitochondrial (mt) genome is catalyzed by nuclear-encoded proteins that include the core RNA polymerase (RNAP) subunit Rpo41 and the transcription factor Mtf1. Rpo41 is homologous to the single-su