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Akademický článek

Activation of GPR4 by acidosis increases endothelial cell adhesion through the cAMP/Epac pathway.

Autor: Aishe Chen, Lixue Dong, Nancy R Leffler, Adam S Asch, Owen N Witte, Li V Yang

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e27586 (2011)

Endothelium-leukocyte interaction is critical for inflammatory responses. Whereas the tissue microenvironments are often acidic at inflammatory sites, the mechanisms by which cells respond to acidosis are not well understood. Using molecular, cellula

Externí odkaz: https://doaj.org/article/994ed0562af04fe7b1e9b943adf53691

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Acupuncture induces adenosine in fibroblasts through energy metabolism and promotes proliferation by activating MAPK signaling pathway via adenosine

Autor: Fei, Qu, Yanru, Cui, Jie, Zeng, Mingyue, Zhang, Shaying, Qiu, Xiaoting, Huang, Aishe, Chen

Publikováno v: Journal of cellular physiology. 235(3)

Acupuncture has many advantages in the treatment of certain diseases as opposed to drug therapy. Besides, adenosine has been revealed to affect cellular progression including proliferation. Therefore, this study aimed at exploring the mechanism invol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::762a80d45cc533f637fc57552173b890
https://pubmed.ncbi.nlm.nih.gov/31556103

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Identification of Essential Residues Involved in the Allosteric Modulation of the Human A3Adenosine Receptor

Autor: Kenneth A. Jacobson, Joshua B. Blaustein, Zhan-Guo Gao, Aishe Chen, Soo-Kyung Kim, Ariel S. Gross

Publikováno v: Molecular Pharmacology. 63:1021-1031

We examined the effects on allosteric modulation and ligand binding of the mutation of amino acid residues of the human A(3) adenosine receptor (A(3)AR) that are hypothesized to be near one of three loci: the putative sodium binding site, the putativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f4fc792c8b3df977328e916d8e0cfd
https://doi.org/10.1124/mol.63.5.1021

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Engineering of A3 adenosine and P2Y nucleotide receptors and their ligands

Autor: Wangzhong Chen, Kenneth A. Jacobson, Hak Sung Kim, Kyeong Lee, Aishe Chen, Soo-Kyung Kim, Zhan-Guo Gao, Bruce T. Liang, Gnana Ravi, Dov Barak, Seong Gon Kim

Publikováno v: Drug Dev Res

Modification of the ribose moiety of nucleotides and nucleosides has provided new insights into structural and conformational requirements for ligands at P2Y nucleotide receptors and at adenosine receptors (ARs). Methanocarba derivatives (containing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9372b350d350708a7f60a45b0ef9de73
https://doi.org/10.1002/ddr.10168

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Acyclic Analogues of Adenosine Bisphosphates as P2Y Receptor Antagonists: Phosphate Substitution Leads to Multiple Pathways of Inhibition of Platelet Aggregation

Autor: Norbert W. Bischofberger, Joe Sennelo, Kenneth A. Jacobson, Aishe Chen, Xiaoquin Cheng, Bin Xu, Andrew Stephens, Hak Sung Kim, Gary Kirschenheuter, Maddalena L. Zighetti, Arthur F Greslin, Soon-Ai Kim, Marco Cattaneo, Gary Cook

Publikováno v: J Med Chem

Activation by ADP of both P2Y(1) and P2Y(12) receptors in platelets contributes to platelet aggregation, and antagonists at these receptor subtypes have antithrombotic properties. In an earlier publication, we have characterized the SAR as P2Y(1) rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b9974b24a7512ac75de46c8d2a5c61
https://doi.org/10.1021/jm020173u

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Identification by Site-directed Mutagenesis of Residues Involved in Ligand Recognition and Activation of the Human A3 Adenosine Receptor

Autor: Kenneth A. Jacobson, Zhan-Guo Gao, Christa E. Müller, Dov Barak, Soo-Kyung Kim, Aishe Chen

Publikováno v: Journal of Biological Chemistry. 277:19056-19063

Ligand recognition has been extensively explored in G protein-coupled A(1), A(2A), and A(2B) adenosine receptors but not in the A(3) receptor, which is cerebroprotective and cardioprotective. We mutated several residues of the human A(3) adenosine re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de333263f61774d4bfa18295b4e92e7
https://doi.org/10.1074/jbc.m110960200

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Allosteric Modulation of A3 Adenosine Receptors by a Series of 3-(2-Pyridinyl)isoquinoline Derivatives

Autor: Christa E. Müller, Jacqueline E. van Muijlwijk-Koezen, Zhan-Guo Gao, Kenneth A. Jacobson, Aishe Chen, Adriaan P. IJzerman

Publikováno v: Molecular Pharmacology. 60:1057-1063

Allosteric modulators of A1 and A2A adenosine receptors have been described; however, for the A3adenosine receptor, neither an allosteric site nor a compound with allosteric effects has been described. In this study, the allosteric modulation of huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37fbc164536de9dfbda38faf69445a12
https://doi.org/10.1124/mol.60.5.1057

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Constitutive Activation of A3 Adenosine Receptors by Site-Directed Mutagenesis

Autor: Dov Barak, Kenneth A. Jacobson, Zhan-Guo Gao, Bruce T. Liang, Aishe Chen

Publikováno v: Biochemical and Biophysical Research Communications. 284:596-601

The objective of this study was to create constitutively active mutant human A 3 adenosine receptors (ARs) using single amino acid replacements, based on findings from other G protein-coupled receptors. A 3 ARs mutated in transmembrane helical domain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff8d0de9e467419e6a287ea2751d6a1
https://doi.org/10.1006/bbrc.2001.5027

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