Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Aishat Motolani"'
Autor:
Lakshmi Prabhu, Matthew Martin, Lan Chen, Özlem Demir, Jiamin Jin, Xiumei Huang, Aishat Motolani, Mengyao Sun, Guanglong Jiang, Harikrishna Nakshatri, Melissa L. Fishel, Steven Sun, Ahmad Safa, Rommie E. Amaro, Mark R. Kelley, Yunlong Liu, Zhong-Yin Zhang, Tao Lu
Publikováno v:
Genes and Diseases, Vol 10, Iss 1, Pp 267-283 (2023)
Market drugs, such as Food and Drug Administration (FDA) or European Medicines Agency (EMA)-approved drugs for specific indications provide opportunities for repurposing for newer therapeutics. This potentially saves resources invested in clinical tr
Externí odkaz:
https://doaj.org/article/c1b0c6c6e2c44a04afeb6c77405f86a9
Autor:
Anbukkarasi Muniyandi, Matthew Martin, Kamakshi Sishtla, Aishat Motolani, Mengyao Sun, Nathan R. Jensen, Xiaoping Qi, Michael E. Boulton, Lakshmi Prabhu, Tao Lu, Timothy W. Corson
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Ocular neovascular diseases including neovascular age-related macular degeneration (nvAMD) are widespread causes of blindness. Patients’ non-responsiveness to currently used biologics that target vascular endothelial growth factor (VEGF) p
Externí odkaz:
https://doaj.org/article/f0a1f78df83048a59d1f98fb75a67cf1
Autor:
Faranak Alipourgivi, Aishat Motolani, Alice Y. Qiu, Wenan Qiang, Guang-Yu Yang, Shuibing Chen, Tao Lu
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 154 (2023)
Colorectal cancer (CRC) is the third leading cause of cancer mortality in the United States, with an estimated 52,000 deaths in 2023. Though significant progress has been made in both diagnosis and treatment of CRC in recent years, genetic heterogene
Externí odkaz:
https://doaj.org/article/c04fd1c81dc24bcca1afa0b1d0fcfbbc
Autor:
Matthew Martin, Aishat Motolani, Hyeong-Geug Kim, Amy M. Collins, Faranak Alipourgivi, Jiamin Jin, Han Wei, Barry A. Wood, Yao-Ying Ma, X. Charlie Dong, Raghavendra G. Mirmira, Tao Lu
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1457 (2023)
Dysregulation of metabolic functions in the liver impacts the development of diabetes and metabolic disorders. Normal liver function can be compromised by increased inflammation via the activation of signaling such as nuclear factor (NF)-κB signalin
Externí odkaz:
https://doaj.org/article/fe15b2cdd26a480d8b9e5d43cb4c7d13
Autor:
Aishat Motolani, Matthew Martin, Benlian Wang, Guanglong Jiang, Faranak Alipourgivi, Xiumei Huang, Ahmad Safa, Yunlong Liu, Tao Lu
Publikováno v:
Cancers, Vol 15, Iss 19, p 4742 (2023)
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with a mere 5-year survival of ~10%. This highlights the urgent need for innovative treatment options for PDAC patients. The nuclear factor κB (NF-κB) is a crucial tran
Externí odkaz:
https://doaj.org/article/a33f8bdcc9f94338aabaff7a7e796e6b
Autor:
Han Wei, Antja-Voy Hartley, Aishat Motolani, Guanglong Jiang, Ahmad Safa, Lakshmi Prabhu, Yunlong Liu, Tao Lu
Publikováno v:
Genes and Diseases, Vol 9, Iss 2, Pp 285-287 (2022)
Externí odkaz:
https://doaj.org/article/eee52c333e154b389e584adf84c7f6c6
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 8972 (2022)
Alzheimer’s Disease (AD) is the most common neurodegenerative disease worldwide, with a high prevalence that is expected to double every 20 years. Besides the formation of Aβ plaques and neurofibrillary tangles, neuroinflammation is one the major
Externí odkaz:
https://doaj.org/article/bbaaed773e8142289f6387a7163d6536
Publikováno v:
Life, Vol 11, Iss 10, p 1074 (2021)
Since the discovery of protein arginine methyltransferase 5 (PRMT5) and the resolution of its structure, an increasing number of papers have investigated and delineated the structural and functional role of PRMT5 in diseased conditions. PRMT5 is a ty
Externí odkaz:
https://doaj.org/article/b791295fb72e4884a47f4b02b3d11e33
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7429 (2021)
Over the last several decades, colorectal cancer (CRC) has been one of the most prevalent cancers. While significant progress has been made in both diagnostic screening and therapeutic approaches, a large knowledge gap still remains regarding the ear
Externí odkaz:
https://doaj.org/article/e05d2596db3842d19a3bdc9059a432ec
Publikováno v:
Biomolecules, Vol 11, Iss 1, p 15 (2020)
The nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor central to inflammation and various malignant diseases in humans. The regulation of NF-κB can be influenced by a myriad of post-translational modifications (PTMs), including ph
Externí odkaz:
https://doaj.org/article/6f2ec7310af84eeab4f39a8e0a28448f