Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Aishan, Zhao"'
Autor:
Y. Erin Chen, Djenet Bousbaine, Alessandra Veinbachs, Katayoon Atabakhsh, Alex Dimas, Victor K. Yu, Aishan Zhao, Nora J. Enright, Kazuki Nagashima, Yasmine Belkaid, Michael A. Fischbach
Publikováno v:
Science. 380:203-210
Certain bacterial colonists induce a highly specific T cell response. A hallmark of this encounter is that adaptive immunity develops preemptively, in the absence of an infection. However, the functional properties of colonist-induced T cells are not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe8a3b23a94f780827f5623beaec456b
https://doi.org/10.1126/science.abp9563
https://doi.org/10.1126/science.abp9563
Autor:
Linjiao Zhou, Matthew T. Holt, Nami Ohashi, Aishan Zhao, Manuel M. Müller, Boyuan Wang, Tom W. Muir
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
The ubiquitylation of histone H2B on lysine 120 is an important modification with roles in a diverse range of nuclear processes. Here, the authors use 'designer' chromatin to show that H2B-ub orients hDot1L into the correct position for activation.
Externí odkaz:
https://doaj.org/article/c8971f0fedfb44acb73222b3980cc7bc
Autor:
Min Wang, Lucas J. Osborn, Sunit Jain, Xiandong Meng, Allison Weakley, Jia Yan, William J. Massey, Venkateshwari Varadharajan, Anthony Horak, Rakhee Banerjee, Daniela S. Allende, Ricky E. Chan, Adeline M. Hajjar, Alejandra Dimas, Aishan Zhao, Kazuki Nagashima, Alice G. Cheng, Steven Higginbottom, J. Mark Brown, Michael A. Fischbach
The gut microbiome is complex, raising questions about the role of individual strains in the community. Here, we address this question by focusing on a functional unit within the community, the metabolic niche that controls bile acid 7α-dehydroxylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1119b16fc070e9e73b78a59db8a798d6
https://doi.org/10.1101/2022.07.25.501461
https://doi.org/10.1101/2022.07.25.501461
Autor:
Kazuki Nagashima, Aishan Zhao, Katayoon Atabakhsh, Allison Weakley, Sunit Jain, Xiandong Meng, Alice G. Cheng, Min Wang, Steven Higginbottom, Alex Dimas, Pallavi Murugkar, Michael A. Fischbach
Certain bacterial strains from the microbiome induce a potent, antigen-specific T cell response1–5. However, the specificity of microbiome-induced T cells has not been explored at the strain level across the gut community. Here, we colonize germ-fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c537d0743c5bf2e0b4f65249325892e8
https://doi.org/10.1101/2022.05.04.490632
https://doi.org/10.1101/2022.05.04.490632
Autor:
Mareike M. Wiedmann, Tom W. Muir, Qian Xie, Aishan Zhao, Hiroaki Suga, Ivelisse Rodriguez Pagan, Richard P. Novick
Publikováno v:
Chemical Communications. 56:11223-11226
We combined mRNA display technology with lipid-nanodisc based selections and identified high-affinity ligands targeting the integral membrane sensor domain of the histidine kinase AgrC as potent inhibitors of Staphylococcus aureus quorum sensing-modu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3eb630891e4858b19c9970ce9d64fe5
https://doi.org/10.1039/d0cc04873a
https://doi.org/10.1039/d0cc04873a
Autor:
Alice G. Cheng, Po-Yi Ho, Andrés Aranda-Díaz, Sunit Jain, Feiqiao B. Yu, Xiandong Meng, Min Wang, Mikhail Iakiviak, Kazuki Nagashima, Aishan Zhao, Pallavi Murugkar, Advait Patil, Katayoon Atabakhsh, Allison Weakley, Jia Yan, Ariel R. Brumbaugh, Steven Higginbottom, Alejandra Dimas, Anthony L. Shiver, Adam Deutschbauer, Norma Neff, Justin L. Sonnenburg, Kerwyn Casey Huang, Michael A. Fischbach
Publikováno v:
Cell. 185:3617-3636.e19
Efforts to model the human gut microbiome in mice have led to important insights into the mechanisms of host-microbe interactions. However, the model communities studied to date have been defined or complex, but not both, limiting their utility. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ea33431d88a23f22a5f493d6ccf88a
https://doi.org/10.1016/j.cell.2022.08.003
https://doi.org/10.1016/j.cell.2022.08.003
Autor:
Aishan Zhao, Bodine, Steven P., Qian Xie, Boyuan Wang, Ram, Geeta, Novick, Richard P., Muir, Tom W.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 8/16/2022, Vol. 119 Issue 33, p1-9, 32p
Autor:
Qian, Xie, Mareike M, Wiedmann, Aishan, Zhao, Ivelisse R, Pagan, Richard P, Novick, Hiroaki, Suga, Tom W, Muir
Publikováno v:
Chem Commun (Camb)
We combined mRNA display technology with lipid-nanodisc based selections and identified high-affinity ligands targeting the integral membrane sensor domain of the histidine kinase AgrC as potent inhibitors of Staphylococcus aureus quorum sensing-modu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0411c4d49d61ea4fd048270406691b38
https://pubmed.ncbi.nlm.nih.gov/32820778
https://pubmed.ncbi.nlm.nih.gov/32820778
Autor:
Brian T. Chait, Boyuan Wang, Tom W. Muir, Paul Dominic B. Olinares, Richard P. Novick, Qian Xie, Aishan Zhao
Publikováno v:
Cell Chemical Biology. 24:76-86
Staphylococcus aureus employs the receptor histidine kinase (RHK), AgrC, to detect quorum-sensing (QS) pheromones, the autoinducer peptides (AIPs), which regulate the virulence of the bacterium. Variation in the QS circuit divides S. aureus into four
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc52f13fa066ff8eae4762997591016e
https://doi.org/10.1016/j.chembiol.2016.12.008
https://doi.org/10.1016/j.chembiol.2016.12.008
Publikováno v:
Proceedings of the National Academy of Sciences. 112:10679-10684
Staphylococci produce autoinducing peptides (AIPs) as quorum-sensing signals that regulate virulence. These AIPs feature a thiolactone macrocycle that connects the peptide C terminus to the side chain of an internal cysteine. AIPs are processed from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d0773e75dc8750683186021dd0a982
https://doi.org/10.1073/pnas.1506030112
https://doi.org/10.1073/pnas.1506030112