Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Aisha Shamas‐Din"'
Autor:
Tao Xu, Skander Jemaa, Manas Kumar, Sandhya Balasubramanian, Aisha Shamas-Din, Svetlana Lyalina, Souhila Ounadjela, Bilal Malik, Joe Lee, Salvador Figueroa Morales, Tina Nielsen, Rick Ad Carano, Lale Kostakoglu, William Capra
Publikováno v:
HemaSphere, Vol 7, p e53649d2 (2023)
Externí odkaz:
https://doaj.org/article/8203aa5f0dec40f9b3b175c80f800d61
Autor:
Gregory A. Reed, Gary J. Schiller, Suman Kambhampati, Martin S. Tallman, Dan Douer, Mark D. Minden, Karen W. Yee, Vikas Gupta, Joseph Brandwein, Yulia Jitkova, Marcela Gronda, Rose Hurren, Aisha Shamas‐Din, Andre C. Schuh, Aaron D. Schimmer
Publikováno v:
Cancer Medicine, Vol 5, Iss 11, Pp 3031-3040 (2016)
Abstract Acute myeloid leukemia (AML) cells meet the higher energy, metabolic, and signaling demands of the cell by increasing mitochondrial biogenesis and mitochondrial protein translation. Blocking mitochondrial protein synthesis through genetic an
Externí odkaz:
https://doaj.org/article/a10c49769cfe4648b838a6df9401d3ca
Autor:
Victor Sanjit Nirmalanandhan, Rose Hurren, William D. Cameron, Marcela Gronda, Aisha Shamas-Din, Lidan You, Mark D. Minden, Jonathan V. Rocheleau, Aaron D Schimmer
Publikováno v:
Haematologica, Vol 100, Iss 10 (2015)
Externí odkaz:
https://doaj.org/article/0ce49881b68d4ee682aad4799686124e
Autor:
Rebecca R. Laposa, Dana Yehudai, Rose Hurren, Xiaoming Wang, Daina Avizonis, Gaëlle Bridon, Shrivani Sriskanthadevan, Aisha Shamas-Din, Mark D. Minden, Marcela Gronda, Veronique Voisin, Thirushi P. Siriwardena, Sanduni U. Liyanage, Changjiang Xu, Aaron D. Schimmer, Gary D. Bader, Neil MacLean
Publikováno v:
Blood. 129:2657-2666
Mitochondrial DNA (mtDNA) biosynthesis requires replication factors and adequate nucleotide pools from the mitochondria and cytoplasm. We performed gene expression profiling analysis of 542 human acute myeloid leukemia (AML) samples and identified 55
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a03ddb39984d3b6f5bdfce69409af1bc
https://doi.org/10.1182/blood-2016-10-741207
https://doi.org/10.1182/blood-2016-10-741207
Autor:
Neil MacLean, Stuart R. Wood, Etienne Coyaud, Ian J. Holt, Rose Hurren, Aisha Shamas-Din, Sanduni U. Liyanage, Brian Raught, Estelle M.N. Laurent, Lawrence Kazak, Aaron D. Schimmer
Publikováno v:
Mitochondrion. 32:31-35
Human mitochondrial DNA (mtDNA) is replicated by the mitochondrial DNA polymerase gamma (POLG). Using proximity dependent biotin labelling (BioID), we characterized the POLG interactome and identified new interaction partners involved in mtDNA mainte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2933e33da1f3c9c9416400b5f65c166
https://doi.org/10.1016/j.mito.2016.11.001
https://doi.org/10.1016/j.mito.2016.11.001
Autor:
Vikas Gupta, Karen W.L. Yee, Deborah Sanfelice, Andre C. Schuh, Aisha Shamas-Din, David W. Hedley, Matthew D. Seftel, Sue Chow, Joseph Brandwein, Aaron D. Schimmer
Publikováno v:
Leukemia & Lymphoma. 57:2437-2440
Elesclomol is a novel, injectable, small molecule chemotherapeutic agent that has demonstrated preclinical efficacy in AML.[1,2] Mechanistically, elesclomol binds copper (Cu) in the form of Cu2+ in...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d442a66e295bf8fc1a2464639319f1d
https://doi.org/10.3109/10428194.2016.1138293
https://doi.org/10.3109/10428194.2016.1138293
Autor:
Christian Bogner, Xiaoke Chi, Aisha Shamas-Din, Cécile Fradin, Justin Kale, Justin Pogmore, Brian Leber, David W. Andrews
Publikováno v:
Molecular Cell. 77:901-912.e9
Current models of apoptosis regulation by the Bcl-2 family of proteins postulate that heterodimeric interactions between family members determine whether Bax and Bak are activated to trigger cell death. Thus, the relative abundance and binding affini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3bb73c9305b9a12b47ccf62a98bf9a0
https://doi.org/10.1016/j.molcel.2019.12.025
https://doi.org/10.1016/j.molcel.2019.12.025
Autor:
Christian, Bogner, Justin, Kale, Justin, Pogmore, Xiaoke, Chi, Aisha, Shamas-Din, Cécile, Fradin, Brian, Leber, David W, Andrews
Publikováno v:
Molecular cell. 77(4)
Current models of apoptosis regulation by the Bcl-2 family of proteins postulate that heterodimeric interactions between family members determine whether Bax and Bak are activated to trigger cell death. Thus, the relative abundance and binding affini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1aad7ee0c2c7ff0df891f24d4b5e64d4
https://pubmed.ncbi.nlm.nih.gov/32001105
https://pubmed.ncbi.nlm.nih.gov/32001105
Autor:
Aaron D. Schimmer, Aisha Shamas-Din
Publikováno v:
Experimental Hematology. 43:713-717
Participation of academic centers in aspects of drug discovery and development beyond target identification and clinical trials is rapidly increasing. Yet many academic drug discovery projects continue to stall at the level of chemical probes, and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e38805d16d677b9fb581d1e8bc4824
https://doi.org/10.1016/j.exphem.2015.02.007
https://doi.org/10.1016/j.exphem.2015.02.007
Publikováno v:
Biochemical Journal. 467:495-505
After exposure to stressful stimuli, apoptotic signals can be relayed to mitochondria by pro-apoptotic activator proteins, tBid (truncated Bid/p15) and Bim (Bcl-2 interacting mediator), which activate Bax (Bcl-2 associated X protein) and or Bak (Bcl-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b922ec04b2e280934f73f9332b33cb
https://doi.org/10.1042/bj20141291
https://doi.org/10.1042/bj20141291