Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Aisha Alsfouk"'
1
Akademický článek
Design and Synthesis of Novel Aminoindazole-pyrrolo[2,3-b]pyridine Inhibitors of IKKα That Selectively Perturb Cellular Non-Canonical NF-κB Signalling
Autor: Christopher Riley, Usama Ammar, Aisha Alsfouk, Nahoum G. Anthony, Jessica Baiget, Giacomo Berretta, David Breen, Judith Huggan, Christopher Lawson, Kathryn McIntosh, Robin Plevin, Colin J. Suckling, Louise C. Young, Andrew Paul, Simon P. Mackay
Publikováno v: Molecules, Vol 29, Iss 15, p 3515 (2024)
The inhibitory-kappaB kinases (IKKs) IKKα and IKKβ play central roles in regulating the non-canonical and canonical NF-κB signalling pathways. Whilst the proteins that transduce the signals of each pathway have been extensively characterised, the
Externí odkaz: https://doaj.org/article/e3e2e03e3b834ed6981a0d5113267e5c
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2
Akademický článek
In silico and in vitro evaluation of the anti-virulence potential of patuletin, a natural methoxy flavone, against Pseudomonas aeruginosa
Autor: Ahmed Metwaly, Moustafa M. Saleh, Aisha Alsfouk, Ibrahim M. Ibrahim, Muhamad Abd-Elraouf, Eslam Elkaeed, Hazem Elkady, Ibrahim Eissa
Publikováno v: PeerJ, Vol 12, p e16826 (2024)
This study aimed to investigate the potential of patuletin, a rare natural flavonoid, as a virulence and LasR inhibitor against Pseudomonas aeruginosa. Various computational studies were utilized to explore the binding of Patuletin and LasR at a mole
Externí odkaz: https://doaj.org/article/fb50493f3d6942128f63cef8d38cffaf
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3
Akademický článek
Small molecule inhibitors of cyclin-dependent kinase 9 for cancer therapy
Autor: Aisha Alsfouk
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 693-706 (2021)
Cyclin-dependent kinase 9 (CDK9) plays a vital role in transcription through regulation of short-lived anti-apoptotic genes required for cancer cell survival. Therefore, targeting CDK9 with small molecule inhibitors has emerged as a potential cancer
Externí odkaz: https://doaj.org/article/0ed0b6c616ea42839ec2d1aefac55bbd
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4
Akademický článek
Crystal structures and Hirshfeld surface analysis of 2-(adamantan-1-yl)-5-(4-fluorophenyl)-1,3,4-oxadiazole and 2-(adamantan-1-yl)-5-(4-chlorophenyl)-1,3,4-oxadiazole
Autor: Lamya H. Al-Wahaibi, Aisha Alsfouk, Ali A. El-Emam, Olivier Blacque
Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 75, Iss 5, Pp 611-615 (2019)
The crystal structures of the title adamantane-oxadiazole hybrid compounds, C18H19FN2O (I) and C18H19ClN2O (II), are built up from an adamantane unit and a halogenophenyl ring, [X = F (I), Cl (II)], in position 5 on the central 1,3,4-oxadiazole unit.
Externí odkaz: https://doaj.org/article/7eb5097d97e34b61a72aa4ef2743a6a8
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6
New Anticancer Theobromine Derivative Targeting EGFRWT and EGFRT790M: Design, Semi-Synthesis, In Silico, and In Vitro Anticancer Studies
Autor: Ibrahim Eissa, Aisha Alsfouk, Dalal Husein, Hazem Elkady, Ibrahim Mohamed, Reda Yousef, Ahmed Metwaly, Eslam Basiouny Elkaeed
Publikováno v: Molecules; Volume 27; Issue 18; Pages: 5859
Based on the pharmacophoric features of EGFR inhibitors, a new semisynthetic theobromine-derived compound was designed to interact with the catalytic pocket of EGFR. Molecular docking against wild (EGFRWT; PDB: 4HJO) and mutant (EGFRT790M; PDB: 3W2O)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee4c481beeb47a88f4c7dacfc822c37
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7
Molecular Docking and Dynamic Simulation Revealed the Potential Inhibitory Activity of Opioid Compounds Targeting the Main Protease of SARS-CoV-2
Autor: Elshimaa Abdelhafez, Eslam Basiouny Elkaeed, Samaher Sayed, Aisha Alsfouk
Publikováno v: BioMed research international. 2022
Opioids are a class of chemicals, naturally occurring in the opium poppy plant, and act on the brain to cause a range of impacts, notably analgesic and anti-inflammatory actions. Moreover, an overview was taken in consideration for SARS-CoV-2 inciden
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5840ebfa9e19b60eb439578deddc42a
https://pubmed.ncbi.nlm.nih.gov/36588530
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8
Discovery of Potential SARS-CoV-2 Papain-like Protease Natural Inhibitors Employing a Multi-Phase In Silico Approach
Autor: Abdulrahman M. Saleh, Ibrahim Eissa, Aisha Alsfouk, Ahmed Metwaly, Mohammed s Alesawy, Eslam Basiouny Elkaeed
Publikováno v: Life; Volume 12; Issue 9; Pages: 1407
As an extension of our research against COVID-19, a multiphase in silico approach was applied in the selection of the three most common inhibitors (Glycyrrhizoflavone (76), Arctigenin (94), and Thiangazole (298)) against papain-like protease, PLpro (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b980d1b3eeb6732a36618c727beaf7a1
https://doi.org/10.3390/life12091407
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9
The Assessment of Anticancer and VEGFR-2 Inhibitory Activities of a New 1H-Indole Derivative: In Silico and In Vitro Approaches
Autor: Ibrahim Eissa, Aisha Alsfouk, Dalal Husein, Hazem Elkady, Ibrahim Mohamed, Reda Yousef, Ahmed Metwaly, Ibraheem Mostafa Ibraheem Mohammed, Eslam Basiouny Elkaeed
Publikováno v: Processes; Volume 10; Issue 7; Pages: 1391
Corresponding to the reported features of anti-VEGFR-2-approved compounds, a new 1H-indole derivative (compound 7) was designed. The inhibitory potential of the designed compound was revealed via a molecular docking study that showed the appropriate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8bd31c85b7a50c81dea85d436c24d98
https://doi.org/10.3390/pr10071391
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