DNA methylation signatures of adolescent victimization: analysis of a longitudinal monozygotic twin sample

Autor: Radhika Kandaswamy, Eilis Hannon, Louise Arseneault, Georgina Mansell, Karen Sugden, Benjamin Williams, Joe Burrage, James R Staley, Ehsan Pishva, Aisha Dahir, Susanna Roberts, Andrea Danese, Jonathan Mill, Helen L Fisher, Chloe C. Y. Wong

Publikováno v: Epigenetics, Vol 16, Iss 11, Pp 1169-1186 (2021)

Accumulating evidence suggests that individuals exposed to victimization at key developmental stages may have different epigenetic fingerprints compared to those exposed to no/minimal stressful events, however results are inconclusive. This study aim

Externí odkaz: https://doaj.org/article/c24e922fd7bc4d3991b7688caaddd685

PDX1LOW MAFALOW β-cells contribute to islet function and insulin release

Autor: Daniela Nasteska, Nicholas H. F. Fine, Fiona B. Ashford, Federica Cuozzo, Katrina Viloria, Gabrielle Smith, Aisha Dahir, Peter W. J. Dawson, Yu-Chiang Lai, Aimée Bastidas-Ponce, Mostafa Bakhti, Guy A. Rutter, Remi Fiancette, Rita Nano, Lorenzo Piemonti, Heiko Lickert, Qiao Zhou, Ildem Akerman, David J. Hodson

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

Beta cell subpopulations with low expression in PDX1, MAFA, and insulin might contribute to islet function and insulin release. Here the authors show that altering the proportion of PDX1LOW MAFALOW to PDX1HIGH MAFAHIGH cells impairs islet function.

Externí odkaz: https://doaj.org/article/cf504598ffd644018cbb1c9c1fc2bf2c

Characterizing the properties of bisulfite sequencing data: maximizing power and sensitivity to identify between-group differences in DNA methylation

Autor: Isabel Castanho, Eilis Hannon, Aisha Dahir, Dorothea Seiler Vellame, Jonathan Mill

Publikováno v: BMC Genomics, Vol 22, Iss 1, Pp 1-16 (2021)
BMC Genomics

Background The combination of sodium bisulfite treatment with highly-parallel sequencing is a common method for quantifying DNA methylation across the genome. The power to detect between-group differences in DNA methylation using bisulfite-sequencing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e9c8b6f7cc66ed75dd7593ae6b572d
https://doaj.org/article/edc75c961ca64a479ac03dcf4a9936b1

PDX1LOW MAFALOW β-cells contribute to islet function and insulin release

Autor: David J. Hodson, Federica Cuozzo, Peter W. J. Dawson, Remi Fiancette, Aisha Dahir, Katrina Viloria, Daniela Nasteska, Mostafa Bakhti, Ildem Akerman, Qiao Zhou, Fiona B. Ashford, Gabrielle Smith, Heiko Lickert, Rita Nano, Aimée Bastidas-Ponce, Yu-Chiang Lai, Nicholas H. F. Fine, Guy A. Rutter, Lorenzo Piemonti

Publikováno v: Nat. Commun. 12:674 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

Transcriptionally mature and immature β-cells co-exist within the adult islet. How such diversity contributes to insulin release remains poorly understood. Here we show that subtle differences in β-cell maturity, defined using PDX1 and MAFA express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed6129b09188b234293ada2d9e691a2
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=61196

Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex

Autor: Meena Kumari, Paul T. Francis, Kevin Morgan, Jonathan P. Davies, Rebecca G. Smith, Leonard C. Schalkwyk, Emma Walker, Joe Burrage, Grant W. A. Neilson, Alan J. Thomas, Eilis Hannon, Jonathan Mill, Aisha Dahir, Gemma Shireby, Katie Lunnon, Keeley J. Brookes, Seth Love

Publikováno v: Brain
Shireby, G L, Davies, J P, Francis, P T, Burrage, J, Walker, E M, Neilson, G W A, Dahir, A, Thomas, A J, Love, S, Smith, R G, Lunnon, K, Kumari, M, Schalkwyk, L C, Morgan, K, Brookes, K, Hannon, E & Mill, J 2020, ' Recalibrating the epigenetic clock : implications for assessing biological age in the human cortex ', Brain . https://doi.org/10.1093/brain/awaa334

Existing DNA methylation clocks are highly accurate in blood but are less precise when used in older samples or on brain tissue. Shireby et al. develop a novel epigenetic clock that performs optimally in human cortical tissue and has the potential to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0504283b10226f4cd412d4743b3702dd
https://irep.ntu.ac.uk/id/eprint/40540/7/1355119_a1132_Brookes.pdf