Immature reticulocyte fraction: A novel biomarker of hemodynamic severity in pulmonary arterial hypertension

Autor: Adam J. Brownstein, Jared D. Wilkinson, Lloyd L. Liang, Richard N. Channick, Rajan Saggar, Airie Kim

Publikováno v: Pulmonary Circulation, Vol 14, Iss 3, Pp n/a-n/a (2024)

Abstract Various erythropoietic abnormalities are highly prevalent among patients with pulmonary arterial hypertension (PAH) and associated with worse disease severity. Given the poorly understood yet important roles of dysregulated erythropoiesis an

Externí odkaz: https://doaj.org/article/5a5c36a2962a43a9aeda90032b392f1c

Iron overload causes a mild and transient increase in acute lung injury

Autor: Vida Zhang, Tomas Ganz, Elizabeta Nemeth, Airie Kim

Publikováno v: Physiological Reports, Vol 8, Iss 12, Pp n/a-n/a (2020)

Abstract Recent studies have demonstrated a strong link between acute respiratory distress syndrome (ARDS) and the levels of iron and iron‐related proteins in the lungs. However, the role of iron overload in ARDS development has yet to be character

Externí odkaz: https://doaj.org/article/5f56cd957efc4280828531f509c2df0b

Mouse models of anemia of cancer.

Autor: Airie Kim, Seth Rivera, Dana Shprung, Donald Limbrick, Victoria Gabayan, Elizabeta Nemeth, Tomas Ganz

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e93283 (2014)

Anemia of cancer (AC) may contribute to cancer-related fatigue and impair quality of life. Improved understanding of the pathogenesis of AC could facilitate better treatment, but animal models to study AC are lacking. We characterized four syngeneic

Externí odkaz: https://doaj.org/article/49f22d18d7d24a8e8b265291e7ba7189

A mouse model characterizes the roles of ZIP8 in systemic iron recycling and lung inflammation and infection

Autor: Vida Zhang, Supak Jenkitkasemwong, Qingli Liu, Tomas Ganz, Elizabeta Nemeth, Mitchell D. Knutson, Airie Kim

Publikováno v: Blood advances.

ZIP8 (SLC39A8) is a transmembrane divalent metal ion importer that is most highly expressed in the lung and is inducible by inflammatory stimuli. In addition to zinc and manganese, ZIP8 can transport iron, but its specific roles in iron regulation du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30335a53e824b831c6c3ad9ef085f421
https://pubmed.ncbi.nlm.nih.gov/36260707

Expression of Iron‐Regulatory Hormone Hepcidin and Iron Transporters Ferroportin and ZIP8 in Patients With and Without Chronic Rhinosinusitis

Autor: Marilene B. Wang, Airie Kim, David W. Hsu, Jivianne T. Lee, Tomas Ganz, Tara J. Wu, Jeffrey D. Suh

Publikováno v: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, vol 163, iss 6
Otolaryngol Head Neck Surg

Airway epithelia express intrinsic antimicrobial and nutrient-sequestering factors, which contribute to the host defense of the respiratory tract. Hepcidin is an endogenous peptide hormone that serves as a key regulator of iron metabolism, and ferrop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739fe3c23b0d625e3eca480347d0b13f
https://doi.org/10.1177/0194599820939910