Neuraminidase is a host‐directed approach to regulate neutrophil responses in sepsis and COVID‐19.

Autor: de Oliveira Formiga, Rodrigo, Amaral, Flávia C., Souza, Camila F., Mendes, Daniel A. G. B., Wanderley, Carlos W. S., Lorenzini, Cristina B., Santos, Adara A., Antônia, Juliana, Faria, Lucas F., Natale, Caio C., Paula, Nicholas M., Silva, Priscila C. S., Fonseca, Fernanda R., Aires, Luan, Heck, Nicoli, Starick, Márick R., Queiroz‐Junior, Celso M., Santos, Felipe R. S., de Souza, Filipe R. O., Costa, Vivian V.

Publikováno v: British Journal of Pharmacology; Jun2023, Vol. 180 Issue 11, p1460-1481, 22p, 8 Graphs

Neuraminidase inhibitors rewire neutrophil function in murine sepsis and COVID-19 patients’ cells

Autor: Formiga, Rodrigo O., Amaral, Flávia C., Souza, Camila F., Mendes, Daniel A. G. B., Wanderley, Carlos W. S., Lorenzini, Cristina B., Santos, Adara A., Antônia, Juliana, Faria, Lucas F., Natale, Caio C., Paula, Nicholas M., Silva, Priscila C. S., Fonseca, Fernanda R., Aires, Luan, Heck, Nicoli, Barroso, Shana P. C., Morrot, Alexandre, Sordi, Regina, Alisson-Silva, Frederico, Mansur, Daniel S., Cunha, Fernando Q., Maurici, Rosemeri, Báfica, André, Macauley, Matthew S., Spiller, Fernando

Publikováno v: bioRxiv
article-version (status) pre
article-version (number) 2

Neutrophils overstimulation plays a crucial role in tissue damage during severe infections. Neuraminidase-mediated cleavage of surface sialic acid has been demonstrated to regulate leukocyte responses. Here, we report that antiviral neuraminidase inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37e5a0bc3d258069dfe24370beebd806
http://europepmc.org/articles/PMC7668734

Neuraminidase inhibitors rewire neutrophil function in vivo in murine sepsis and ex vivo in COVID-19.

Autor: de Oliveira Formiga R; Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.; Université de Paris, Institut Cochin, INSERM U1016, CNRS, Paris, France.; Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil., Amaral FC; Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.; Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil., Souza CF; Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil., Mendes DAGB; Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.; Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil., Wanderley CWS; Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil., Lorenzini CB; Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.; Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil., Santos AA; Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.; Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil., Antônia J; Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil., Faria LF; Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil., Natale CC; Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.; Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil., Paula NM; Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.; Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil., Silva PCS; Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil., Fonseca FR; Department of Clinical Medicine, Federal University of Santa Catarina, Florianopolis, SC, Brazil., Aires L; Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.; Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil., Heck N; Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.; Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil., Starick MR; Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.; Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil., Queiroz-Junior CM; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Santos FRS; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., de Souza FRO; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Costa VV; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Barroso SPC; Molecular Biology Laboratory, Institute of Biomedical Research, Marcilio Dias Naval Hospital, Navy of Brazil, RJ, Brazil., Morrot A; Tuberculosis Research Laboratory, Faculty of Medicine, Federal University of Rio de Janeiro.; Immunoparasitology Laboratory, Oswaldo Cruz Foundation, FIOCRUZ, Rio de Janeiro, Brazil., Van Weyenbergh J; Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory for Clinical and Epidemiological Virology, KU Leuven, Leuven, Belgium., Sordi R; Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil., Alisson-Silva F; Department of Immunology, Paulo de Goes Institute of Microbiology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil., Cunha FQ; Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil., Rocha EL; Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.; Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil., Chollet-Martin S; INSERM UMR 996, 'Infammation, Microbiome and Immunosurveillance', Faculty of Pharmacy, Université Paris-Saclay, Châtenay-Malabry, France., Hurtado-Nedelec MM; INSERM-U1149, Faculté de Médecine, Site Xavier Bichat, CNRS, Université de Paris, Paris, France., Martin C; Université de Paris, Institut Cochin, INSERM U1016, CNRS, Paris, France.; Department of Pneumology, AP-HP, Hôpital Cochin, Paris, France., Burgel PR; Université de Paris, Institut Cochin, INSERM U1016, CNRS, Paris, France.; Department of Pneumology, AP-HP, Hôpital Cochin, Paris, France., Mansur DS; Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil., Maurici R; Department of Clinical Medicine, Federal University of Santa Catarina, Florianopolis, SC, Brazil., Macauley MS; Department of Chemistry, Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada., Báfica A; Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil., Witko-Sarsat V; Université de Paris, Institut Cochin, INSERM U1016, CNRS, Paris, France., Spiller F; Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.; Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2022 Oct 14. Date of Electronic Publication: 2022 Oct 14.