Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Aiqin Cao"'
Autor:
Sarasa Isobe, Ramesh V. Nair, Helen Y. Kang, Lingli Wang, Jan-Renier Moonen, Tsutomu Shinohara, Aiqin Cao, Shalina Taylor, Shoichiro Otsuki, David P. Marciano, Rebecca L. Harper, Mir S. Adil, Chongyang Zhang, Mauro Lago-Docampo, Jakob Körbelin, Jesse M. Engreitz, Michael P. Snyder, Marlene Rabinovitch
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Pulmonary arterial hypertension (PAH) is a progressive disease in which pulmonary arterial (PA) endothelial cell (EC) dysfunction is associated with unrepaired DNA damage. BMPR2 is the most common genetic cause of PAH. We report that human P
Externí odkaz:
https://doaj.org/article/77e16fe3567e4a3f89266732e6c31cf1
Autor:
Shoichiro Otsuki, Toshie Saito, Shalina Taylor, Dan Li, Jan-Renier Moonen, David P. Marciano, Rebecca L. Harper, Aiqin Cao, Lingli Wang, Maria E. Ariza, Marlene Rabinovitch
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
We previously reported heightened expression of the human endogenous retroviral protein HERV-K deoxyuridine triphosphate nucleotidohydrolase (dUTPase) in circulating monocytes and pulmonary arterial (PA) adventitial macrophages of patients with PA hy
Externí odkaz:
https://doaj.org/article/cef82f1c90464af295d891c0012529c9
Autor:
Caiyun G. Li, Cathal Mahon, Nathaly M. Sweeney, Erik Verschueren, Vivek Kantamani, Dan Li, Jan K. Hennigs, David P. Marciano, Isabel Diebold, Ossama Abu-Halawa, Matthew Elliott, Silin Sa, Feng Guo, Lingli Wang, Aiqin Cao, Christophe Guignabert, Julie Sollier, Nils P. Nickel, Mark Kaschwich, Karlene A. Cimprich, Marlene Rabinovitch
Publikováno v:
Cell Reports, Vol 26, Iss 5, Pp 1333-1343.e7 (2019)
Summary: Using proteomic approaches, we uncovered a DNA damage response (DDR) function for peroxisome proliferator activated receptor γ (PPARγ) through its interaction with the DNA damage sensor MRE11-RAD50-NBS1 (MRN) and the E3 ubiquitin ligase UB
Externí odkaz:
https://doaj.org/article/4b2b333c73b8412195c17cfba09e970c
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 3, Pp 518-530 (2011)
PCSK9 degrades LDL receptor (LDLR) in liver and thereby influences the circulating level of LDL cholesterol. Hence, mechanisms inhibiting PCSK9 expression have potential for cholesterol-lowering intervention. Previously, we demonstrated that oncostat
Externí odkaz:
https://doaj.org/article/dfeb03a099aa4097b5be575b07a1853a
Autor:
Lingli Wang, Jan-Renier Moonen, Aiqin Cao, Sarasa Isobe, Caiyun G. Li, Nancy F. Tojais, Shalina Taylor, David P. Marciano, Pin-I. Chen, Mingxia Gu, Dan Li, Rebecca L. Harper, Nesrine El-Bizri, Yu-Mee Kim, Kryn Stankunas, Marlene Rabinovitch
Publikováno v:
Circulation Research. 132:545-564
Objective: Mutations in BMPR2 (bone morphogenetic protein receptor 2) are associated with familial and sporadic pulmonary arterial hypertension (PAH). The functional and molecular link between loss of BMPR2 in pulmonary artery smooth muscle cells (PA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1b4e5aab3c4e747e36400325397c920
https://doi.org/10.1161/circresaha.121.320541
https://doi.org/10.1161/circresaha.121.320541
Autor:
Shalina Taylor, Sarasa Isobe, Aiqin Cao, Kévin Contrepois, Bérénice A. Benayoun, Lihua Jiang, Lingli Wang, Stavros Melemenidis, Mehmet O. Ozen, Shoichiro Otsuki, Tsutomu Shinohara, Andrew J. Sweatt, Jordan Kaplan, Jan-Renier Moonen, David P. Marciano, Mingxia Gu, Kazuya Miyagawa, Brandon Hayes, Raymond G. Sierra, Christopher J. Kupitz, Patricia A. Del Rosario, Andrew Hsi, A. A. Roger Thompson, Maria E. Ariza, Utkan Demirci, Roham T. Zamanian, Francois Haddad, Mark R. Nicolls, Michael P. Snyder, Marlene Rabinovitch
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 206:1019-1034
Rationale: The role of neutrophils and their extracellular vesicles (EVs) in the pathogenesis of pulmonary arterial hypertension is unclear. Objectives: Relate functional abnormalities in pulmonary arterial hypertension neutrophils and their EVs to m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a69d63632739333b28d4a5d6ec5adec
https://doi.org/10.1164/rccm.202102-0446oc
https://doi.org/10.1164/rccm.202102-0446oc
Autor:
Haowen Zhong, Mengbi Zhang, Xiaoyan Su, Yuqin Qin, Yanhong Lai, Jianhua Chen, Linqing Chen, Aiqin Cao, Xun Liu, Shaohong Li
Publikováno v:
Medical Science Monitor; 10/17/2023, Vol. 29, p1-6, 6p
Autor:
Selena Ferrian, Erin F. Mccaffrey, Toshie Saito, Aiqin Cao, Noah F. Greenwald, Mark R. Nicolls, Trevor Bruce, Roham T. Zamanian, Patricia Del Rosario, Marlene Rabinovitch, Michael Angelo
RationaleExperimental and clinical observations are advancing immunotherapies to clinical trial in pulmonary arterial hypertension (PAH). However, comprehensive mapping of the immune landscape in and around pulmonary arteries (PAs) in lung tissue is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b1686ec7e2f78e1c70f732a258df06e
https://doi.org/10.1101/2022.12.03.518033
https://doi.org/10.1101/2022.12.03.518033
Autor:
Md Khadem Ali, Yu Liu, Lan Zhao, Joseph C. Wu, Vinicio de Jesus Perez, Christopher J. Rhodes, Aiqin Cao, Martin R. Wilkins, Mark R. Nicolls, Edda F. Spiekerkoetter
This study shows that the long non-coding RNA RGMB-AS1 is upregulated in the blood and pulmonary vascular cells of PAH patient and that it regulates BMPR2 signaling. Inhibiting RGMB-AS1 increases BMPR2 signaling and improves pulmonary vascular cell f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a1c2c2abc961c29649bf7341618cf04
https://doi.org/10.1101/2022.08.27.505495
https://doi.org/10.1101/2022.08.27.505495
Autor:
Marlene Rabinovitch, Toshie Saito, Maria Eugenia Ariza, Shoichiro Otsuki, Jan-Renier A. J. Moonen, Lingli Wang, Aiqin Cao, David Marciano, Dan Li, Shalina Taylor, Rebecca L. Harper
Publikováno v:
JCI Insight
We previously reported heightened expression of the human endogenous retroviral protein HERV-K deoxyuridine triphosphate nucleotidohydrolase (dUTPase) in circulating monocytes and pulmonary arterial (PA) adventitial macrophages of patients with PA hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a39ba2d584fa0c65fc5a6e2161a459
http://europepmc.org/articles/PMC8410063
http://europepmc.org/articles/PMC8410063