Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Aiqi Fang"'
Tetanus toxin production in soy-based medium: nutritional studies and scale-up into small fermentors
Publikováno v:
Letters in Applied Microbiology. 45:635-638
Aims: To further improve the soy-based medium, devoid of animal and dairy products, for a production of tetanus toxin by nutritional studies and to scale-up the Clostridium tetani process into small fermentors. Methods and Results: Optimum production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c1491543a7fe1850ba8a8fcc4b8b44f
https://doi.org/10.1111/j.1472-765x.2007.02238.x
https://doi.org/10.1111/j.1472-765x.2007.02238.x
Publikováno v:
Applied Microbiology and Biotechnology. 73:55-59
When tetanus toxin is made by fermentation with Clostridium tetani, the traditional source of iron is an insoluble preparation called reduced iron powder. This material removes oxygen from the system by forming FeO(2) (rust). When inoculated in a new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99cdc4e13860d1f0b4ffd3696bdcbfe
https://doi.org/10.1007/s00253-006-0450-2
https://doi.org/10.1007/s00253-006-0450-2
Autor:
Eric Frost, Jacques Pépin, Michel Warny, Jon S. Brazier, L. Clifford McDonald, George Killgore, Aiqi Fang, Angela Thompson
Publikováno v:
The Lancet. 366:1079-1084
Summary Background Toxins A and B are the primary virulence factors of Clostridium difficile . Since 2002, an epidemic of C difficile -associated disease with increased morbidity and mortality has been present in Quebec province, Canada. We character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4dcf240562d2e54eeb3ef3eab511084
https://doi.org/10.1016/s0140-6736(05)67420-x
https://doi.org/10.1016/s0140-6736(05)67420-x
Autor:
Arnold L. Demain, Aiqi Fang
Publikováno v:
The Chemical Record. 1:333-346
We have studied microbial secondary metabolism in a simulated microgravity (SMG) environment provided by NASA rotating-wall bioreactors (RWBs). These reactors were designed to simulate some aspects of actual microgravity that occur in space. Growth a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6cf2377bc45e1bbf13b5c2b430f235
https://doi.org/10.1002/tcr.1018
https://doi.org/10.1002/tcr.1018
Publikováno v:
The Journal of Antibiotics. 53:158-162
Streptomyces hygroscopicus ATCC 29253 produces rapamycin, elaiophylin and nigericin. Although elaiophylin has no activity against Candida albicans ATCC 11651, it markedly enhances rapamycin's antifungal activity. Nigericin has only weak activity on i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecdd1b9529c66572e01ca813fe78d161
https://doi.org/10.7164/antibiotics.53.158
https://doi.org/10.7164/antibiotics.53.158
Autor:
Aiqi Fang, Arnold L. Demain
Publikováno v:
Applied Microbiology and Biotechnology. 47:547-553
Previous studies [Connell et al. (1987) Mol Microbiol 1: 195-201] have shown that expression of the microcin B17 (MccB17) promoter is inversely related to the growth rate of the culture, when slower growth was brought about by limitation of sources o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88cbb4eff12a803b22a1149d53089072
https://doi.org/10.1007/s002530050971
https://doi.org/10.1007/s002530050971
Publikováno v:
Journal of Industrial Microbiology and Biotechnology. 18:22-25
Rotating bioreactors designed at NASA's Johnson Space Center were used to simulate a microgravity environment in which to study secondary metabolism. The system examined was beta-lactam antibiotic production by Streptomyces clavuligerus. Both growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6131f0b4213b20af9e4e3ff98da8b1a
https://doi.org/10.1038/sj.jim.2900345
https://doi.org/10.1038/sj.jim.2900345
Autor:
Aiqi Fang, Oscar Ferrero, Saul Wolfe, Michael Yu. Lebedev, Kiyoshi Maeda, José M. Luengo, Arnold L. Demain
Publikováno v:
Enzyme and Microbial Technology. 17:231-234
Cell-free extracts of Streptomyces clavuligerus contain the enzyme deacetoxycephalosporin C synthase (“expandase”), which catalyzes the oxidative ring expansion of the natural substrate δ- d -α-aminoadipyl-6-APA (penicillin N) into the primary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba6475d8a0622be56467b3dd6d3ddc9d
https://doi.org/10.1016/0141-0229(94)00001-8
https://doi.org/10.1016/0141-0229(94)00001-8
Autor:
Aiqi Fang, Arnold L. Demain
Publikováno v:
Actinomycetologica. 9:98-117
Secondary metabolism in actinomycetes is brought on by exhaustion of a nutrient and/or by a growth rate decrease. These events generate signals which effect a cascade of regulatory events resulting in chemical differentiation (secondary metabolism) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0db645c69abd1d4a10b0d1d551ce1fa5
https://doi.org/10.3209/saj.9_98
https://doi.org/10.3209/saj.9_98
Publikováno v:
Letters in Applied Microbiology. 31:39-41
Glucose interference in production of microcin B17 by Escherichia coli ZK650 was decreased sevenfold by growth in a ground-based rotating-wall bioreactor operated in the simulated microgravity mode as compared with growth in flasks. When cells were g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3d09f03adb21ab3d6c428f3b7010c44
https://doi.org/10.1111/j.1472-765x.2000.00762.x
https://doi.org/10.1111/j.1472-765x.2000.00762.x