Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Ainoleena Turku"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The class Frizzled of G protein-coupled receptors (GPCRs) consist of ten Frizzled (FZD1-10) subtypes and Smoothened (SMO). Here the Schulte laboratory demonstrates that FZDs differ substantially from SMO in receptor activation-associated conformation
Externí odkaz:
https://doaj.org/article/210a27d0ce7040bd89c4edb6636fa89d
Autor:
Paweł Kozielewicz, Ainoleena Turku, Carl-Fredrik Bowin, Julian Petersen, Jana Valnohova, Maria Consuelo Alonso Cañizal, Yuki Ono, Asuka Inoue, Carsten Hoffmann, Gunnar Schulte
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
WNT-Frizzled (FZD) signaling plays a critical role in embryonic development, tissue homeostasis and human disease but no small molecule drugs targeting FZD with distinct efficacy have emerged so far. Here, authors identify the Smoothened agonist SAG1
Externí odkaz:
https://doaj.org/article/cdfb04c677084c808ef1126575dae7a6
Autor:
Riccardo Provenzani, Ilari Tarvainen, Giulia Brandoli, Antti Lempinen, Sanna Artes, Ainoleena Turku, Maria Helena Jäntti, Virpi Talman, Jari Yli-Kauhaluoma, Raimo K Tuominen, Gustav Boije Af Gennäs
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195668 (2018)
Protein kinase C (PKC) isoforms play a pivotal role in the regulation of numerous cellular functions, making them extensively studied and highly attractive drug targets. Utilizing the crystal structure of the PKCδ C1B domain, we have developed hydro
Externí odkaz:
https://doaj.org/article/011c3ac1fd414b3695e15b73be2e16e1
Autor:
Nita R. Shah, Craig Wilkinson, Steven P. D. Harborne, Ainoleena Turku, Kun-Mou Li, Yuh-Ju Sun, Sarah Harris, Adrian Goldman
Publikováno v:
Structural Dynamics, Vol 4, Iss 3, Pp 032105-032105-12 (2017)
Membrane-integral pyrophosphatases (mPPases) couple the hydrolysis of pyrophosphate (PPi) to the pumping of Na+, H+, or both these ions across a membrane. Recently solved structures of the Na+-pumping Thermotoga maritima mPPase (TmPPase) and H+-pumpi
Externí odkaz:
https://doaj.org/article/317fe7dc8b6547d3aeee4f1e62d4d008
Autor:
Ainoleena Turku, Maiju K Rinne, Gustav Boije Af Gennäs, Henri Xhaard, Dan Lindholm, Jyrki P Kukkonen
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178526 (2017)
Two promising lead structures of small molecular orexin receptor agonist have been reported, but without detailed analyses of the pharmacological properties. One of them, 1-(3,4-dichlorophenyl)-2-[2-imino-3-(4-methylbenzyl)-2,3-dihydro-1H-benzo[d]imi
Externí odkaz:
https://doaj.org/article/d9d6d479432e4f74a00380e93b4b81dc
Autor:
Teppo O. Leino, Ainoleena Turku, Lauri Urvas, Karuna Adhikari, Jouni Oksanen, Yana Steynen, Jari Yli-Kauhaluoma, Henri Xhaard, Jyrki P. Kukkonen, Erik A.A. Wallén
Azulene is a rare ring structure in drugs, and we investigated whether it could be used as a biphenyl mimetic in known orexin receptor agonist Nag 26, which is binding to both orexin receptors OX1 and OX2 with preference towards OX2. The most potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7df09711b7611d8344b9ac76de0bc4c
http://hdl.handle.net/10138/359559
http://hdl.handle.net/10138/359559
Autor:
Bo Chen, Fei Xu, Michel Bouvier, Shane C. Wright, Ainoleena Turku, Chao Li, Lu Xu, Maria Kowalski-Jahn, Paweł Kozielewicz, Yiran Wu, Gye Won Han, Carl-Fredrik Bowin, Hannes Schihada, Gunnar Schulte, Xianjun Zhang
Publikováno v:
Cell Research
Autor:
Niklas G. Johansson, Evgeni Grazhdankin, Loic Dreano, Ayman Khattab, Colin W. G. Fishwick, Ainoleena Turku, Alexandros Kiriazis, Jari Yli-Kauhaluoma, Henri Xhaard, Daniel Ayuso Pérez, Adrian Goldman, Gustav Boije af Gennäs, Aaron Wilkinson, Yuezhou Zhang, Keni Vidilaseris, Matti Tamminen, Seppo Meri
Publikováno v:
ACS Medicinal Chemistry Letters
Membrane-bound pyrophosphatases (mPPases) regulate energy homeostasis in pathogenic protozoan parasites and lack human homologues, which makes them promising targets in e.g. malaria. Yet only few nonphosphorus inhibitors have been reported so far. He
Publikováno v:
Molecular Pharmacology. 97:23-34
Smoothened (SMO) is a GPCR that mediates hedgehog signaling. Hedgehog binds the transmembrane protein Patched, which in turn regulates SMO activation. Overactive SMO signaling is oncogenic and is therefore a clinically established drug target. Here w
Autor:
Hannes Schihada, Ainoleena Turku, Maria Kowalski-Jahn, Thomas P. Sakmar, Gunnar Schulte, Thomas Huber
Publikováno v:
Science Advances
Description
WNTs induce conformational changes in the extracellular CRD of Frizzleds irrespective of their signaling profile.
Frizzleds (FZD1–10) are G protein–coupled receptors containing an extracellular cysteine-rich domain (CRD) bin
WNTs induce conformational changes in the extracellular CRD of Frizzleds irrespective of their signaling profile.
Frizzleds (FZD1–10) are G protein–coupled receptors containing an extracellular cysteine-rich domain (CRD) bin