Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Aino Ruusala"'
Autor:
Chun-Yu Lin, Kaustuv Basu, Aino Ruusala, Inna Kozlova, Yan-Shuang Li, Spyridon S. Skandalis, Carl-Henrik Heldin, Paraskevi Heldin
Publikováno v:
Cancers
Volume 15
Issue 4
Pages: 1082
Volume 15
Issue 4
Pages: 1082
In the present study, we show that the inhibitor of the apoptosis-stimulating protein of p53 (iASPP) physically interacts with the hyaluronan receptor CD44 in normal and transformed cells. We noticed that the CD44 standard isoform (CD44s), but not th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd7faa20d8f3e4e609475a809e80043
Autor:
Pontus Aspenström, Aino Ruusala
Publikováno v:
Molecular and Cellular Biology. 28:1802-1814
The Cdc42-like GTPase Wnt responsive Cdc42 homolog 1 (Wrch1) has several atypical features; it has an N-terminal proline-rich extension that confers binding to SH3 domains, and it harbors an extremely high intrinsic nucleotide exchange activity, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b952b3fd69eee4b9d396c65e80481360
https://doi.org/10.1128/mcb.00201-07
https://doi.org/10.1128/mcb.00201-07
Publikováno v:
Experimental Cell Research. 313:3673-3679
The Rho GTPases are influential regulators of signalling pathways that control vital cellular processes such as cytoskeletal dynamics, gene transcription, cell cycle progression and cell transformation. A vast majority of the studies involving Rho GT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29926f59a6c7c7fc95476c3a13ced251
https://doi.org/10.1016/j.yexcr.2007.07.022
https://doi.org/10.1016/j.yexcr.2007.07.022
Autor:
Nuria Ortega Vico, Antti Hassinen, Raija Tammi, Paraskevi Heldin, Ashik Jawahar Deen, Aino Ruusala, Genevieve Bart, Sakari Kellokumpu, Marukku I. Tammi, François M. Pujol, Anthony Squire
In vertebrates, hyaluronan is produced in the plasma membrane from cytosolic UDP-sugar substrates by hyaluronan synthase 1-3 (HAS1-3) isoenzymes that transfer N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcUA) in alternative positions in the gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03339473a172337b7d63995a22d93c95
https://europepmc.org/articles/PMC4416852/
https://europepmc.org/articles/PMC4416852/
Publikováno v:
Biochemical and Biophysical Research Communications. 344:500-510
We recently described the atypical Rho GTPases Miro-1 and Miro-2. These proteins have tandem GTP-binding domains separated by a linker region with putative calcium-binding motives. In addition, the Miro GTPases have a C-terminal transmembrane domain,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5473414d35d0b51045173961ffa7b74e
https://doi.org/10.1016/j.bbrc.2006.03.163
https://doi.org/10.1016/j.bbrc.2006.03.163
Autor:
Aino Ruusala, Pontus Aspenström
Publikováno v:
FEBS Letters. 572:159-166
In a yeast two-hybrid system screen for Cdc42-interacting proteins, we identified a protein with similarity to the CrkII-binding protein DOCK180. A cDNA clone of this protein, designated DOCK8, encoded a gene-product of 1701 amino acid residues with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26914b239670df227c3e04a06f7f5e9d
https://doi.org/10.1016/j.febslet.2004.06.095
https://doi.org/10.1016/j.febslet.2004.06.095
Publikováno v:
Journal of Biological Chemistry. 278:6495-6502
The human genomic sequencing effort has revealed the presence of a large number of Rho GTPases encoded by the human genome. Here we report the characterization of a new family of Rho GTPases with atypical features. These proteins, which were called M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a375d1259d38674fd2528e054f0db0
https://doi.org/10.1074/jbc.m208609200
https://doi.org/10.1074/jbc.m208609200
Publikováno v:
FEBS Letters. 450:1-7
In this study we show that platelet-derived growth factor (PDGF)-induced DNA binding as well as transcriptional activation of Stat5b are markedly increased by inhibition of the MAP (mitogen-activated protein) kinase kinase MEK. In addition to the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e25fc9bfe932da4b7378a940158c68
https://doi.org/10.1016/s0014-5793(99)00459-7
https://doi.org/10.1016/s0014-5793(99)00459-7
Publikováno v:
Molecular Biology of the Cell
RhoD has a role in actin dynamics that is distinct from RhoA, Rac1, and Cdc42. Data presented here indicate that RhoD binds the actin nucleation–promoting factor WASp homologue associated with actin Golgi membranes and microtubules (WHAMM) and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6501a004164e63c9b009d180ee7ef0ac
Publikováno v:
Cellular signalling. 24(9)
IQGAP1, an essential scaffolding protein, forms a complex with the hyaluronan receptor CD44. In this study, we have examined the importance of IQGAP1 for hyaluronan-mediated fibroblast migration and proliferation. Hyaluronan induced formation of F-ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5439923a1260319a8df41f48ca0ef2
https://pubmed.ncbi.nlm.nih.gov/22634185
https://pubmed.ncbi.nlm.nih.gov/22634185