Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Aini Vuorinen"'
Autor:
Thomas R. Jackson, Aini Vuorinen, Laia Josa-Culleré, Katrina S. Madden, Daniel Conole, Thomas J. Cogswell, Isabel V.L. Wilkinson, Laura M. Kettyle, Douzi Zhang, Alison O’Mahony, Deanne Gracias, Lorna McCall, Robert Westwood, Georg C. Terstappen, Stephen G. Davies, Edward W. Tate, Graham M. Wynne, Paresh Vyas, Angela J. Russell, Thomas A. Milne
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104787- (2022)
Summary: Despite much progress in developing better drugs, many patients with acute myeloid leukemia (AML) still die within a year of diagnosis. This is partly because it is difficult to identify therapeutic targets that are effective across multiple
Externí odkaz:
https://doaj.org/article/41383f2f5a8d4ffeb2940ad8bb573d15
Autor:
Arron Aatkar, Aini Vuorinen, Oliver E. Longfield, Katharine Gilbert, Rachel Peltier-Heap, Craig D. Wagner, Francesca Zappacosta, Katrin Rittinger, Chun-wa Chung, David House, Nicholas C. O. Tomkinson, Jacob T. Bush
Publikováno v:
ACS Chemical Biology.
Sulfur(VI) fluorides (SFs) have emerged as valuable electrophiles for the design of 'beyond cysteine' covalent inhibitors, and offer potential for expansion of the liganded proteome. Since SFs target a broad range of nucleophilic amino acids, they de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e549ee29bfb50bf0d4a55e881a9deeae
https://doi.org/10.1021/acschembio.3c00034
https://doi.org/10.1021/acschembio.3c00034
Autor:
Rosa Cookson, Aini Vuorinen, Jonathan Pettinger, Cassandra R. Kennedy, Joanna M. Kirkpatrick, Rachel E. Peltier-Heap, Andrew Powell, Ambrosius P. Snijders, Mark Skehel, David House, Katrin Rittinger, Jacob T. Bush
SummaryChemoproteomics is a powerful method capable of detecting interactions between small molecules and the proteome, however its use as a high-throughput screening method for chemical libraries has so far been limited. To address this need, we hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ff8aafd003a34329baeafd8d02f1023
https://doi.org/10.1101/2023.02.01.526632
https://doi.org/10.1101/2023.02.01.526632
Autor:
Katharine E. Gilbert, Aini Vuorinen, Arron Aatkar, Peter Pogány, Jonathan Pettinger, Emma K. Grant, Joanna M. Kirkpatrick, Katrin Rittinger, David House, Glenn A. Burley, Jacob T. Bush
A comprehensive profiling of sulfur(VI) fluoride reactivity is reported in the context of fragment binders and optimized probes. The reactivity profile of an SVI-F panel is demonstrated using live cell chemoproteomics. The studies provide an in-depth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59458f436898af2b214b686cc11b1373
Autor:
Katharine Gilbert, Aini Vuorinen, Arron Aatkar, Peter Pogany, Jonathan Pettinger, Emma Grant, Joanna Kirkpatrick, Katrin Rittinger, David House, Glenn Burley, Jacob Bush
Chemical probes are valuable tools to explore the function of proteins. Incorporation of electrophiles into small molecules enables covalent capture of protein interactions and provides access to powerful technologies including chemoproteomic profili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c682ac958f31adc0e5cdc60ca3d96ac9
https://doi.org/10.26434/chemrxiv-2022-j8b8d-v2
https://doi.org/10.26434/chemrxiv-2022-j8b8d-v2
Autor:
Petri M. Pihko, Ádám Madarász, Kai Tai Yip, Mikko V. Leskinen, Antti J. Neuvonen, Aini Vuorinen, Imre Pápai
Publikováno v:
Journal of the American Chemical Society. 136(17):6453-6462
Cross-dehydrogenative coupling reactions between β-ketoesters and electron-rich arenes, such as indoles, proceed with high regiochemical fidelity with a range of β-ketoesters and indoles. The mechanism of the reaction between a prototypical β-keto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62f3888f3af7fcf0f9bee31903f3b4b
https://doi.org/10.1021/ja501681y
https://doi.org/10.1021/ja501681y
Autor:
Imre Pápai, Mikko V. Leskinen, Kai Tai Yip, Antti J. Neuvonen, Aini Vuorinen, Petri M. Pihko, Ádám Madarász
Publikováno v:
ChemInform. 45
Cross-dehydrogenative coupling reactions between β-ketoesters and electron-rich arenes, such as indoles, proceed with high regiochemical fidelity with a range of β-ketoesters and indoles. The mechanism of the reaction between a prototypical β-keto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e40b1d100e5afd85293cc5a935bc7002
https://doi.org/10.1002/chin.201446141
https://doi.org/10.1002/chin.201446141