Výsledky vyhledávání - "Ainhoa Moliner Morro"

Akademický článek

Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH

Autor: Tim Schulte, Marc D. Panas, Xiao Han, Lucy Williams, Nancy Kedersha, Jonas Simon Fleck, Timothy J. C. Tan, Xaquin Castro Dopico, Anders Olsson, Ainhoa Moliner Morro, Leo Hanke, Johan Nilvebrant, Kim Anh Giang, Per-Åke Nygren, Paul Anderson, Adnane Achour, Gerald M. McInerney

Publikováno v: Open Biology, Vol 13, Iss 5 (2023)

G3BP is the central node within stress-induced protein–RNA interaction networks known as stress granules (SGs). The SG-associated proteins Caprin-1 and USP10 bind mutually exclusively to the NTF2 domain of G3BP1, promoting and inhibiting SG formati

Externí odkaz: https://doaj.org/article/719e066a65f94ead97a58a120d59ffcd

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Akademický článek

Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Many interactions between viral and host proteins are mediated by short peptide motifs. Here, using a phage-based viral peptide library, the authors identify 269 peptide-based interactions for 18 coronaviruses, including an interaction between SARS-C

Externí odkaz: https://doaj.org/article/1f444706eff944aca145f8ed28412f90

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Akademický článek

Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus

Autor: Margit Mutso, Ainhoa Moliner Morro, Cecilia Smedberg, Sergo Kasvandik, Muriel Aquilimeba, Mona Teppor, Liisi Tarve, Aleksei Lulla, Valeria Lulla, Sirle Saul, Bastian Thaa, Gerald M McInerney, Andres Merits, Margus Varjak

Publikováno v: Viruses, Vol 10, Iss 5, p 226 (2018)

Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus

Externí odkaz: https://doaj.org/article/436e6e42498f4d28a75d5d8db1b0d5fb

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Author response for 'Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH'

Autor: null Tim Schulte, null Marc D. Panas, null Xiao Han, null Lucy Williams, null Nancy Kedersha, null Jonas Simon Fleck, null Timothy J. C. Tan, null Xaquin Castro Dopico, null Anders Olsson, null Ainhoa Moliner Morro, null Leo Hanke, null Johan Nilvebrant, null Kim Anh Giang, null Per-Åke Nygren, null Paul Anderson, null Adnane Achour, null Gerald M. McInerney

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f406bebec2fbab5f7e9a3dbba5cb3d3
https://doi.org/10.1098/rsob.220369/v2/response1

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Protection against SARS-CoV-2 transmission by a parenteral prime—Intranasal boost vaccine strategy

Publikováno v: Christensen, D, Polacek, C, Sheward, D J, Hanke, L, Moliner-morro, A, Mcinerney, G, Murrell, B, Hartmann, K T, Jensen, H E, Jungersen, G, Illigen, K, Isling, L K, Jensen, R F, Hansen, J S, Rosenkrands, I, Fernandez-antunez, C, Ramirez, S, Follmann, F, Bukh, J & Pedersen, G K 2022, ' Protection against SARS-CoV-2 transmission by a parenteral prime—Intranasal boost vaccine strategy ', EBioMedicine, vol. 84, 104248 . https://doi.org/10.1016/j.ebiom.2022.104248

BackgroundLicensed vaccines against SARS-CoV-2 effectively protect against severe disease, but display incomplete protection against virus transmission. Mucosal vaccines providing immune responses in the upper airways are one strategy to protect agai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2478ec4aa0e62dda8ed072c9896cfd5e
https://curis.ku.dk/portal/da/publications/protection-against-sarscov2-transmission-by-a-parenteral-primeintranasal-boost-vaccine-strategy(a89bca21-8a1d-4c31-b509-47e01826cdbd).html

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Nanobodies in the limelight: Multifunctional tools in the fight against viruses

Autor: Gerald McInerney, Leo Hanke, Ainhoa Moliner Morro

Publikováno v: Journal of General Virology

Antibodies are natural antivirals generated by the vertebrate immune system in response to viral infection or vaccination. Unsurprisingly, they are also key molecules in the virologist’s molecular toolbox. With new developments in methods for prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e82a7f92070cd80c278fbe2ac61d8f4

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Caprin-1 binding to the critical stress granule protein G3BP1 is regulated by pH

Autor: Gerald M. McInerney, Olsson A, Per-Åke Nygren, Ainhoa Moliner Morro, Paul A. Anderson, Williams L, Leo Hanke, Timothy J. C. Tan, Adnane Achour, Panas, Giang Ka, Johan Nilvebrant, Tim Schulte, Nancy Kedersha, Fleck Js

G3BP is the central hub within the protein-RNA interaction network of stress-induced bio-molecular condensates known as stress granules (SG). The SG-associated proteins Caprin-1 and USP10 exhibit mutually exclusive binding to the structured NTF2-doma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a00cfe16e54dff8c9bf6d6ea7c83ce7
https://doi.org/10.1101/2021.02.05.429362

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Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities

Publikováno v: bioRxiv
Kruse, T, Benz, C, Garvanska, D H, Lindqvist, R, Mihalic, F, Coscia, F, Inturi, R, Sayadi, A, Simonetti, L, Nilsson, E, Ali, M, Kliche, J, Moliner Morro, A, Mund, A, Andersson, E, McInerney, G, Mann, M, Jemth, P, Davey, N E, Överby, A K, Nilsson, J & Ivarsson, Y 2021, ' Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities ', Nature Communications, vol. 12, no. 1, 6761 . https://doi.org/10.1038/s41467-021-26498-z
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Viral proteins make extensive use of short peptide interaction motifs to hijack cellular host factors. However, most current large-scale methods do not identify this important class of protein-protein interactions. Uncovering peptide mediated interac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15dfa469f4d1901888b1c305c45a2fae

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Picomolar SARS-CoV-2 Neutralization UsingMulti-Arm PEG Nanobody Constructs

Autor: Ainhoa Moliner-Morro, Daniel J. Sheward, Vivien Karl, Laura Perez Vidakovics, Ben Murrell, Gerald M. McInerney, Leo Hanke

Publikováno v: Biomolecules
Volume 10
Issue 12
Biomolecules, Vol 10, Iss 1661, p 1661 (2020)

Multivalent antibody constructs have a broad range of clinical and biotechnological applications. Nanobodies are especially useful as components for multivalent constructs as they allow increased valency while maintaining a small molecule size. We he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e45115437df463d13c73093fe0b74b41

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