Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Ainhoa, Arina"'
Autor:
David J. Voce, Giovanna M. Bernal, Kirk E. Cahill, Longtao Wu, Nassir Mansour, Clayton D. Crawley, Paige-Ashley S. Campbell, Ainhoa Arina, Ralph R. Weichselbaum, Bakhtiar Yamini
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The alkylating agent, temozolomide (TMZ), is the most commonly used chemotherapeutic for the treatment of glioblastoma (GBM). The anti-glioma effect of TMZ involves a complex response that includes G2-M cell cycle arrest and cyclin-dependent
Externí odkaz:
https://doaj.org/article/a43b98628f924851b3c674791b7711df
Autor:
Ainhoa Arina, Michael Beckett, Christian Fernandez, Wenxin Zheng, Sean Pitroda, Steven J. Chmura, Jason J. Luke, Martin Forde, Yuzhu Hou, Byron Burnette, Helena Mauceri, Israel Lowy, Tasha Sims, Nikolai Khodarev, Yang-Xin Fu, Ralph R. Weichselbaum
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Lymphocytes are considered one of the most radiosensitive cell types in the body. Here the authors show that unlike circulating lymphocytes, tumor-infiltrating T cells survive therapeutic doses of irradiation, remaining functional and contributing to
Externí odkaz:
https://doaj.org/article/d33bd7c45d314883a3946267882043c5
Autor:
Hans Schreiber, Donald A. Rowley, David H. Munn, Robert M. Hoffman, Ming Zhao, Christian Idel, Byron Burnette, Theodore Karrison, Yang-Xin Fu, James M. Slauch, Ping Yu, Ainhoa Arina, Boris Engels, David C. Binder
Immunogenic tumors grow progressively even when heavily infiltrated by CD8+ T cells. We investigated how to rescue CD8+ T-cell function in long-established immunogenic melanomas that contained a high percentage of endogenous PD-1+ tumor-specific CD8+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b7aea1d18fbbfd533cd3b004403fce6
https://doi.org/10.1158/2326-6066.c.6548200.v1
https://doi.org/10.1158/2326-6066.c.6548200.v1
Autor:
Hans Schreiber, Ralph R. Weichselbaum, Karin Schreiber, Eva Galka, Theodore Karrison, Ainhoa Arina
Suppl. Figure 1. A. Tumors that escape an equilibrium caused by CD8 T cells targeting tumor stroma are not Ag-loss variants. B. The Ag-specific lytic function of 2C cells in vivo has not declined in mice bearing escaping tumors. C. Equilibrium can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5238e2aa03ae1e2fb4e1631b5f9db273
https://doi.org/10.1158/2326-6066.22538738
https://doi.org/10.1158/2326-6066.22538738
Autor:
Hans Schreiber, Ralph R. Weichselbaum, Karin Schreiber, Eva Galka, Theodore Karrison, Ainhoa Arina
Adoptively transferred CD8+ T cells can stabilize the size of solid tumors over long periods of time by exclusively recognizing antigen cross-presented on tumor stroma. However, these tumors eventually escape T-cell–mediated growth control. The aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::692c7a94d5ebbff4f7c1a8d46e44a68f
https://doi.org/10.1158/2326-6066.c.6548873.v1
https://doi.org/10.1158/2326-6066.c.6548873.v1
Autor:
Hans Schreiber, Donald A. Rowley, David H. Munn, Robert M. Hoffman, Ming Zhao, Christian Idel, Byron Burnette, Theodore Karrison, Yang-Xin Fu, James M. Slauch, Ping Yu, Ainhoa Arina, Boris Engels, David C. Binder
PDF file - 291K, Figure S1. A1-R SIINF preferentially accumulates in established B16-OVA tumors. Figure S2. A1-R SIINF induces systemic SIINF-specific CD8+ T cell proliferation. Figure S3. Weekly A1-R SIINF treatment leads to rejection of established
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b0d63c84519fc855ff8f969b7d8d4d
https://doi.org/10.1158/2326-6066.22536661
https://doi.org/10.1158/2326-6066.22536661
Autor:
Hans Schreiber, Donald A. Rowley, David H. Munn, Robert M. Hoffman, Ming Zhao, Christian Idel, Byron Burnette, Theodore Karrison, Yang-Xin Fu, James M. Slauch, Ping Yu, Ainhoa Arina, Boris Engels, David C. Binder
PDF file - 122K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8be637d9b1a0ae102719cd23ed33bc0
https://doi.org/10.1158/2326-6066.22536658
https://doi.org/10.1158/2326-6066.22536658
Autor:
Hans Schreiber, Ralph R. Weichselbaum, Karin Schreiber, Eva Galka, Theodore Karrison, Ainhoa Arina
Cytokine production by 2C CD8+ T cells from mice treated or not with allogeneic CD4+ T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8d49636d3c9b648a4f8bf307ad459b
https://doi.org/10.1158/2326-6066.22538735.v1
https://doi.org/10.1158/2326-6066.22538735.v1
Autor:
Hans Schreiber, Yusuke Nakamura, Wolfgang Uckert, Ralph R. Weichselbaum, Jaikumar Duraiswamy, Ainhoa Arina, Christian Idel, Kazuma Kiyotani, Poh Yin Yew, Karin Schreiber, Boris Engels, Matthias Leisegang
Supplementary Methods - Contains detailed information on whole exome and RNA sequencing, variant calling, TCR gene transfer, and longitudinal imaging Supplementary Fig. S1 - Pipeline for exome/RNA analysis and neoepitope prediction Supplementary Fig.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152acad500d53e6fc038965a880846e6
https://doi.org/10.1158/1078-0432.22456394.v1
https://doi.org/10.1158/1078-0432.22456394.v1
Autor:
Hans Schreiber, Donald A. Rowley, Ralph R. Weichselbaum, Theodore G. Karrison, Alessandro Sette, John Sidney, Michael T. Spiotto, Boris Engels, Ainhoa Arina, Karin Schreiber
Purpose: Solid tumors that have grown two weeks or longer in mice and have diameters larger than 1 cm are histologically indistinguishable from autochthonous human cancers. When experimental tumors reach this clinically relevant size, they are usuall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2f245c4529d5d3e3214c4470f1ebf3
https://doi.org/10.1158/1078-0432.c.6520943.v1
https://doi.org/10.1158/1078-0432.c.6520943.v1