Macrophage susceptibility to infection by Ghanaian Mycobacterium tuberculosis complex lineages 4 and 5 varies with self-reported ethnicity

Autor: Stephen Osei-Wusu, John K. A. Tetteh, Abdul Basit Musah, Desmond Opoku Ntiamoah, Nelly Arthur, Abraham Adjei, Ainhoa Arbues, Ebenezer Addo Ofori, Kwadwo Akyea Mensah, Sutaya Elsie Afua Galevo, Abena Frema Frempong, Prince Asare, Adwoa Asante-Poku, Isaac Darko Otchere, Kwadwo Asamoah Kusi, Tobias L. Lenz, Sebastien Gagneux, Damien Portevin, Dorothy Yeboah-Manu

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)

BackgroundThe epidemiology of Mycobacterium tuberculosis complex (MTBC) lineage 5 (L5) infections in Ghana revealed a significantly increased prevalence in Ewes compared to other self-reported ethnic groups. In that context, we sought to investigate

Externí odkaz: https://doaj.org/article/419696aedee245deb914cfed516b9668

Mycobacterial Phenolic Glycolipids Selectively Disable TRIF-Dependent TLR4 Signaling in Macrophages

Autor: Reid Oldenburg, Veronique Mayau, Jacques Prandi, Ainhoa Arbues, Catherine Astarie-Dequeker, Christophe Guilhot, Catherine Werts, Nathalie Winter, Caroline Demangel

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Phenolic glycolipids (PGLs) are cell wall components of a subset of pathogenic mycobacteria, with immunomodulatory properties. Here, we show that in addition, PGLs exert antibactericidal activity by limiting the production of nitric oxide synthase (i

Externí odkaz: https://doaj.org/article/1d1c5fb2289a45fd9d978d6c326af91e

Uma nova vacina viva contra a tuberculose com base na inativação do phoP

Autor: Jesus Gonzalo Asensio, Ainhoa Arbues, Dessi Marinova, Carlos Martín

Publikováno v: Revista Portuguesa de Pneumologia, Vol 16, Iss , Pp S43-S48 (2010)

Externí odkaz: https://doaj.org/article/d499569510e242ba81767c5adf8e0fe2

Mycobacterium leprae PGL-1 expression by BCG increases CR3 mediated entry into mouse myeloid cells and triggers the Syk/NFAT pathway to induce a specific cytokine program

Autor: Emilie Doz-Deblauwe, Florence Carreras, Aude Remot, Ainhoa Arbues, Mathieu Epardaud, Véronqiue Mayaux, Catherine Astarie-Dequeker, Christophe Guilhot, Caroline Demangel, Nathalie Winter

Publikováno v: 5. conférence Mycoclub
5. conférence Mycoclub, Société Française de Microbiologie (SFM). FRA., May 2017, Montigny le Bretonneux, France
HAL

National audience; Introduction : Parmi les molécules lipidiques produites dans la paroi cellulaire des mycobactéries, les glycolipides phénoliques (PGL) ne sont produits que par les principales souches pathogènes pour l’Homme : Mycobacterium t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4bdf72900f50a20546d9ea0325c033cd
https://hal.inrae.fr/hal-02733847

Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials

Autor: Santiago Uranga, Vicente Ausina, Conchita Fernandez, Juan Ignacio Aguilo, Wladimir Malaga, Cristina Vilaplana, Brigitte Gicquel, Simon Clark, Pere-Joan Cardona, Ainhoa Arbues, Alberto Parra, Ann Williams, Eugenia Puentes, Carlos Martin, Dessislava Marinova, Christophe Guilhot, Jesús Gonzalo-Asensio

Publikováno v: Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Vaccine
Vaccine; Vol 31

The development of a new tuberculosis vaccine is an urgent need due to the failure of the current vaccine, BCG, to protect against the respiratory form of the disease. MTBVAC is an attenuated Mycobacterium tuberculosis vaccine candidate genetically e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0054e5ca28b3cdb968669d2c202f90e1
https://doi.org/10.1016/j.vaccine.2013.07.051