Blocking Lipid Uptake Pathways Does not Prevent Toxicity in Adipose Triglyceride Lipase (ATGL) Deficiency

Autor: Jide Oluwadare, Ainara G. Cabodevilla, Ni-Huiping Son, Yunying Hu, Adam E. Mullick, Michael Verano, Jose O. Alemán, Ravichandran Ramasamy, Ira J. Goldberg

Publikováno v: Journal of Lipid Research, Vol 63, Iss 11, Pp 100274- (2022)

Lipid accumulation in nonadipose tissues can cause lipotoxicity, leading to cell death and severe organ dysfunction. Adipose triglyceride lipase (ATGL) deficiency causes human neutral lipid storage disease and leads to cardiomyopathy; ATGL deficiency

Externí odkaz: https://doaj.org/article/f665ac1d40554a758d5215f1f0e19a98

Abstract 115: N-terminus Of ApoB Mediates Endothelial Cell Chylomicron Uptake

Autor: Ainara G Cabodevilla, Narasimha Ananganti, Nada Abumrad, Jose O Aleman, Mahmood M Hussain, Ira J Goldberg

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 42

The development of atherosclerosis is triggered by the endothelial crossing and subendothelial retention of apolipoprotein B (ApoB)-containing LDL and chylomicron remnants. LDL has been reported to cross the endothelial cell (EC) barrier via two rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0276c35960ac56a6278e77f0ae2c406b
https://doi.org/10.1161/atvb.42.suppl_1.115

Endothelial Cell Receptors in Tissue Lipid Uptake and Metabolism

Autor: Debapriya Basu, Dmitri Samovski, Terri A. Pietka, Ainara G. Cabodevilla, Ira J. Goldberg, Nada A. Abumrad

Publikováno v: Circ Res

Lipid uptake and metabolism are central to the function of organs such as heart, skeletal muscle, and adipose tissue. Although most heart energy derives from fatty acids (FAs), excess lipid accumulation can cause cardiomyopathy. Similarly, high deliv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530726c2d692ccd13ab512ffc88b9a41
https://pubmed.ncbi.nlm.nih.gov/33539224

Intrinsic lipid binding activity of ATG16L1 supports efficient membrane anchoring and autophagy

Autor: Leo J, Dudley, Ainara G, Cabodevilla, Agata N, Makar, Martin, Sztacho, Tim, Michelberger, Joseph A, Marsh, Douglas R, Houston, Sascha, Martens, Xuejun, Jiang, Noor, Gammoh

Publikováno v: The EMBO Journal

Membrane targeting of autophagy‐related complexes is an important step that regulates their activities and prevents their aberrant engagement on non‐autophagic membranes. ATG16L1 is a core autophagy protein implicated at distinct phases of autoph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3c6e710a6544b938811cd065b813646f
https://pubmed.ncbi.nlm.nih.gov/30936093

Cell survival during complete nutrient deprivation depends on lipid droplet-fueled beta-oxidation of fatty acids

Autor: Enrique Claro, Eleni Nintou, Fernando Picatoste, Ainara G. Cabodevilla, Laura Sánchez-Caballero, Violeta G. Boiadjieva, Albert Gubern

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Recercat. Dipósit de la Recerca de Catalunya
instname

Cells exposed to stress of different origins synthesize triacylglycerols and generate lipid droplets (LD), but the physiological relevance of this response is uncertain. Using complete nutrient deprivation of cells in culture as a simple model of str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df6409e161274b3dafe642ff682ab84
https://ddd.uab.cat/record/143866