Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease

Autor: Fabia Febbraro, Gurdal Sahin, Aina Farran, Sofia Soares, Poul H. Jensen, Deniz Kirik, Marina Romero-Ramos

Publikováno v: Neurobiology of Disease, Vol 56, Iss , Pp 47-58 (2013)

Alpha-synuclein phosphorylated at serine 129 (S129) is highly elevated in Parkinson's disease patients where it mainly accumulates in the Lewy bodies. Several groups have studied the role of phosphorylation at the S129 in α-synuclein in a rat model

Externí odkaz: https://doaj.org/article/d0fadbd0a5e146d188a2e3262299e943

In vivo effect of opticin deficiency in cartilage in a surgically induced mouse model of osteoarthritis

Autor: Johanne Martel-Pelletier, Jordi Monfort, Gladys Valverde-Franco, Laura Tío, Bertrand Lussier, Aina Farran, Hassan Fahmi, Jean-Pierre Pelletier, Paul N. Bishop

Publikováno v: Farrán, A, Valverde-Franco, G, Tío, L, Lussier, B, Fahmi, H, Pelletier, J-P, Bishop, P N, Monfort, J & Martel-Pelletier, J 2018, ' In vivo effect of opticin deficiency in cartilage in a surgically induced mouse model of osteoarthritis ', Scientific Reports, vol. 8, no. 1, pp. 457 . https://doi.org/10.1038/s41598-017-18047-w
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports

The SLRP opticin (OPTC) has been demonstrated to be produced and degraded in osteoarthritic (OA) human cartilage. Here, we investigated the in vivo effect of OPTC deficiency in OA cartilage. OA was induced in 10-week-old Optc−/− and Optc+/+ mice.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac41d39af6c5a9d598a98114a38eb5ab
https://doi.org/10.1038/s41598-017-18047-w

Targeting of Key Pathogenic Factors From Gram-Positive Bacteria by the Soluble Ectodomain of the Scavenger-Like Lymphocyte Receptor CD6

Autor: Aina Farran, Lizette Bonet-Roselló, Mario Martínez-Florensa, Jordi Vila, Olga Cañadas, Vanesa G. Martínez, Noelia Armiger-Borràs, Francisco Lozano, Cristina Casals, Marta Consuegra-Fernández

Publikováno v: The Journal of Infectious Diseases. 209:1077-1086

Gram-positive bacteria cause a broad spectrum of infection-related diseases in both immunocompetent and immunocompromised hosts, ranging from localized infections to severe systemic conditions such as septic and toxic shock syndromes. This situation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c891489e4ec4ec582bcd10efa34f51
https://doi.org/10.1093/infdis/jit624

In vivo effect of opticin deficiency in a surgically induced model of osteoarthritis

Autor: Frédéric Paré, Aina Farran, Johanne Martel-Pelletier, L. Tío, Gladys Valverde-Franco, Jordi Monfort, J.-P. Pelletier

Publikováno v: Osteoarthritis and Cartilage. 25:S61

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::208e861b36e7356544e0422c43d07101
https://doi.org/10.1016/j.joca.2017.02.111

Characterization of opticin digestion by proteases involved in osteoarthritis development

Autor: Jean-Pierre Pelletier, Peter J. Roughley, Pere Benito, Jordi Monfort, Laura Tío, Aina Farran, Paul N. Bishop, Johanne Martel-Pelletier

Publikováno v: Joint bone spine. 81(2)

OBJECTIVE: Opticin is a class III member of the small leucine-rich repeat proteoglycan (SLRP) family, produced in articular joint tissues. In normal and osteoarthritic (OA) cartilage, opticin is degraded. This study aimed to assess whether human cart

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85db6c7101819d2989895e6ee514c007
https://pubmed.ncbi.nlm.nih.gov/23845380