Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Aimo Kannt"'
Autor:
Andreas Ernst, Andreas Weigert, Priscila da Silva, Javier Mora, Xin You, Svenja Wiechmann, Mateusz Putyrski, Javier Garcia-Pardo, Aimo Kannt, Bernhard Bruene
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 8 (2024)
Background The interleukin (IL)-1-family receptor antagonist IL-38 has emerged as a negative regulator of auto-inflammation. Given the intricate interplay between antitumor immunity and auto-inflammation, we hypothesized that blocking IL-38 may enhan
Externí odkaz:
https://doaj.org/article/6ab5abd72d6643518a19bf5844b185f5
Autor:
Sven Ruf, Sridharan Rajagopal, Sanjay Venkatachalapathi Kadnur, Mahanandeesha S. Hallur, Shilpa Rani, Rajendra Kristam, Srinivasan Swaminathan, Bharat Ravindra Zope, Pavan Kumar Gondrala, Indu Swamy, V. P. Rama Kishore Putta, Saravanan Kandan, Gernot Zech, Herman Schreuder, Christine Rudolph, Ralf Elvert, Joerg Czech, Swarnakumari Birudukota, M. Amir Siddiqui, Niranjan Naranapura Anand, Vishal Subhash Mane, Sreekanth Dittakavi, Juluri Suresh, Ramachandraiah Gosu, Mullangi Ramesh, Takeshi Yura, Saravanakumar Dhakshinamoorthy, Aimo Kannt
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Nicotinamide N-methyltransferase (NNMT) is a metabolic regulator that catalyzes the methylation of nicotinamide (Nam) using the co-factor S-adenosyl-L-methionine to form 1-methyl-nicotinamide (MNA). Overexpression of NNMT and the presence of
Externí odkaz:
https://doaj.org/article/1bd53e86e70b4c66b07f2146adca9f2e
Autor:
Zeynep E. Yesilyurt, Jan Matthes, Edith Hintermann, Tamara R. Castañeda, Ralf Elvert, Jesus H. Beltran-Ornelas, Diana L. Silva-Velasco, Ning Xia, Aimo Kannt, Urs Christen, David Centurión, Huige Li, Andrea Pautz, Ebru Arioglu-Inan, Martin C. Michel
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The urinary bladder is markedly enlarged in the type 1 diabetes mellitus model of streptozotocin-injected rats, which may contribute to the frequent diabetic uropathy. Much less data exists for models of type 2 diabetes. Diabetic polyuria has been pr
Externí odkaz:
https://doaj.org/article/f59087392e074b2ea5f40362b866547a
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Introduction: Genetic studies have identified associations of carnosinase 1 (CN1) polymorphisms with diabetic kidney disease (DKD). However, CN1 levels and activities have not been assessed as diagnostic or prognostic markers of DKD in cohorts of pat
Externí odkaz:
https://doaj.org/article/9ac196f3bfbe47e1aa2b1cb70ad4568f
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract The intra-individual variability of the human serum metabolome over a period of 4 weeks and its dependence on metabolic health and nutritional status was investigated in a single-center study under tightly controlled conditions in healthy co
Externí odkaz:
https://doaj.org/article/af2daeff5b9c45e18f466140866829f2
Autor:
Dieter Schmoll, Nicole Ziegler, Benoit Viollet, Marc Foretz, Patrick C. Even, Dalila Azzout‐Marniche, Andreas Nygaard Madsen, Martin Illemann, Karen Mandrup, Michael Feigh, Jörg Czech, Heiner Glombik, Jacob A. Olsen, Wolfgang Hennerici, Klaus Steinmeyer, Ralf Elvert, Tamara R. Castañeda, Aimo Kannt
Publikováno v:
Hepatology Communications, Vol 4, Iss 7, Pp 1056-1072 (2020)
The worldwide obesity and type 2 diabetes epidemics have led to an increase in nonalcoholic fatty liver disease (NAFLD). NAFLD covers a spectrum of hepatic pathologies ranging from simple steatosis to nonalcoholic steatohepatitis, characterized by fi
Externí odkaz:
https://doaj.org/article/9426e7d8200a4cacaf75487e613184ae
Autor:
Xiaobo Wang, Mark R. Sommerfeld, Kerstin Jahn‐Hofmann, Bishuang Cai, Aveline Filliol, Helen E. Remotti, Robert F. Schwabe, Aimo Kannt, Ira Tabas
Publikováno v:
Hepatology Communications, Vol 3, Iss 9, Pp 1221-1234 (2019)
Nonalcoholic steatohepatitis (NASH) is emerging as a major public health issue and is associated with significant liver‐related morbidity and mortality. At present, there are no approved drug therapies for NASH. The transcriptional coactivator with
Externí odkaz:
https://doaj.org/article/1e86ca922c85434d9c6ee005837b7f83
Autor:
Stavroula Kanoni, Satish Kumar, Charalampia Amerikanou, Mary Jo Kurth, Maria G. Stathopoulou, Stephane Bourgeois, Christine Masson, Aimo Kannt, Lucia Cesarini, Maria-Spyridoula Kontoe, Maja Milanović, Francisco J. Roig, Mirjana Beribaka, Jonica Campolo, Nuria Jiménez-Hernández, Nataša Milošević, Carlos Llorens, Ilias Smyrnioudis, M. Pilar Francino, Nataša Milić, Andriana C. Kaliora, Maria Giovanna Trivella, Mark W. Ruddock, Milica Medić-Stojanoska, Amalia Gastaldelli, John Lamont, Panos Deloukas, George V. Dedoussis, Sophie Visvikis-Siest
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease with no therapeutic consensus. Oxidation and inflammation are hallmarks in the progression of this complex disease, which also involves interactions between the genetic backgr
Externí odkaz:
https://doaj.org/article/01cf24ceb3e947749ca21d7d2aed1f4f
Autor:
Aimo Kannt, Sridharan Rajagopal, Mahanandeesha S. Hallur, Indu Swamy, Rajendra Kristam, Saravanakumar Dhakshinamoorthy, Joerg Czech, Gernot Zech, Herman Schreuder, Sven Ruf
Publikováno v:
Molecules, Vol 26, Iss 4, p 991 (2021)
Nicotinamide-N-methyltransferase (NNMT) is a cytosolic enzyme catalyzing the transfer of a methyl group from S-adenosyl-methionine (SAM) to nicotinamide (Nam). It is expressed in many tissues including the liver, adipose tissue, and skeletal muscle.
Externí odkaz:
https://doaj.org/article/61332a9f60cc407593eef5ac0b48e04f
Autor:
Paulus Wohlfart, Michael Feigh, Sanne Skovgård Veidal, Dieter Schmoll, Aimo Kannt, Andreas Nygaard Madsen
Publikováno v:
British Journal of Pharmacology. 178:2412-2423
Background and purpose Activation of hepatic thyroid hormone receptor β (THR-β) is associated with systemic lipid lowering, increased bile acid synthesis, and fat oxidation. In patients with non-alcoholic steatohepatitis (NASH), treatment with THR-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::618574cab0d5ae9217a76a7917a18501
https://doi.org/10.1111/bph.15427
https://doi.org/10.1111/bph.15427