Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Aimen Aljoundi"'
Autor:
Almahi I. Mohamed, Ochuko L. Erukainure, Veronica F Salau, Nontokozo Z. Msomi, Brian K. Beseni, Kolawole A. Olofinsan, Aimen Aljoundi, Md. Shahidul Islam
Publikováno v:
Scientific African, Vol 26, Iss , Pp e02340- (2024)
The current study assessed the antioxidant and antidiabetic properties of Nauclea latifolia fruit in vitro and in silico. The aqueous infusion of the fruit was analysed for its in vitro antioxidant capacity using ferric-reducing antioxidant power (FR
Externí odkaz:
https://doaj.org/article/cf8fcbcaf11e438ba7aad557f939c03e
Autor:
Ochuko L. Erukainure, Kgalaletso P. Otukile, Karabo R. Harejane, Veronica F. Salau, Aimen Aljoundi, Chika I. Chukwuma, Motlalepula G. Matsabisa
Publikováno v:
Arabian Journal of Chemistry, Vol 16, Iss 7, Pp 104842- (2023)
The present study was aimed at investigating the molecular mechanism involved the antioxidant and antidiabetic activities of cannabidiol using in vitro and in silico models. The antioxidant activities of cannabidiol were determined by assaying its ab
Externí odkaz:
https://doaj.org/article/b403c1873f134adeb7f5998847728edb
Autor:
Kamel Metwally, Nader E. Abo-Dya, Mohammed Issa Alahmdi, Maha Z. Albalawi, Galal Yahya, Aimen Aljoundi, Elliasu Y. Salifu, Ghazi Elamin, Mahmoud A. A. Ibrahim, Yasien Sayed, Sylvia Fanucchi, Mahmoud E. S. Soliman
Publikováno v:
Molecules, Vol 28, Iss 6, p 2806 (2023)
The unusual and interesting architecture of the catalytic chamber of the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) was recently explored using Cryogenic Electron Microscopy (Cryo-EM), which revealed the presence of two distinctive binding caviti
Externí odkaz:
https://doaj.org/article/a3686c20460b45f7b706fbd4b5d44f8d
Publikováno v:
Informatics in Medicine Unlocked, Vol 30, Iss , Pp 100952- (2022)
After decades of leaving patients with limited treatment options due to the ‘undruggability’ of Kirsten rat sarcoma, the kernel was finally cracked with the discovery of Sotorasib. This novel drug binds to a small pocket on the switch II of Kirst
Externí odkaz:
https://doaj.org/article/a3d2232e635341069fb1ff541be49e5b
Publikováno v:
Molecules, Vol 25, Iss 18, p 4239 (2020)
Covalent inhibition has recently gained a resurgence of interest in several drug discovery areas. The expansion of this approach is based on evidence elucidating the selectivity and potency of covalent inhibitors when bound to particular amino acids
Externí odkaz:
https://doaj.org/article/dcea6cc75b1c4af0afc855b08854f5fe
Publikováno v:
Cell Biochemistry and Biophysics. 80:633-645
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::068f74d6de7ffa403a3320013afae542
https://doi.org/10.1007/s12013-022-01101-4
https://doi.org/10.1007/s12013-022-01101-4
Publikováno v:
Cell Biochemistry and Biophysics. 80:495-504
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dcda2c2bfb46bbad29bb95b1f9f45d2
https://doi.org/10.1007/s12013-022-01075-3
https://doi.org/10.1007/s12013-022-01075-3
Publikováno v:
The Protein Journal. 41:201-215
B-cell lymphoma 2 (Bcl2) is a key protein regulator of apoptosis. The hydrophobic groove in Bcl2 is a unique structural feature to this class of enzymes and found to have a profound impact on protein overall structure, function, and dynamics. Dynamic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149eff0a7ca24ea37a8ecdaccacb292f
https://doi.org/10.1007/s10930-022-10046-9
https://doi.org/10.1007/s10930-022-10046-9
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 23
Background: Despite the early success of Bruton's tyrosine kinase (BTK) inhibitors in the treatment of Waldenström macroglobulinemia (WM), these single-target drug therapies have limitations in their clinical applications, such as drug resistance. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e51ecdd73d7ac63bc4e8e2ae17e3f1dd
https://doi.org/10.2174/1871520623666230208102609
https://doi.org/10.2174/1871520623666230208102609
Publikováno v:
Molecular Simulation. 48:197-208
Preclinical evidence suggests effectiveness of the combined inhibition of bromodomain and extra-terminal (BET) and histone deacetylase (HDAC) proteins in the treatment of Waldenstr��m macroglobulinemia (WM). However, toxicity, dosing scheduling,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa251dbab5822cfda5c4c23fd40e5ee8
https://doi.org/10.1080/08927022.2021.2005248
https://doi.org/10.1080/08927022.2021.2005248