Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Aimee O'Donohue"'
Autor:
Peter S. Dragovich, Mingtao He, Leanna Staben, Hongyan Zhang, Melinda M. Mulvihill, Catherine Wilson, Hao Zhou, Tracy Kleinheinz, Binqing Wei, Jianfeng Xin, Nicole Blaquiere, Fanwei Meng, John S. Wai, Susan Kaufman, Liang Liu, Rebecca K. Rowntree, Steven T. Staben, Jing Wang, Katherine R. Kozak, Josefa dela Cruz-Chuh, Zijin Xu, Steven J. Hartman, Robert A. Blake, Xiaoyu Zhu, Sunil Bhakta, Donglu Zhang, Hui Yao, Aimee O'Donohue, Jack Sadowsky, Qi Liu, Pragya Adhikari, Liling Liu, Ying Lu, Thomas H. Pillow, Jinhua Chen, Emel Adaligil, Karen E. Gascoigne
Publikováno v:
Journal of Medicinal Chemistry. 64:2534-2575
The biological and medicinal impacts of proteolysis-targeting chimeras (PROTACs) and related chimeric molecules that effect intracellular degradation of target proteins via ubiquitin ligase-mediated ubiquitination continue to grow. However, these chi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eaea12dee6f95904b15f4c9e925d0b1
https://doi.org/10.1021/acs.jmedchem.0c01845
https://doi.org/10.1021/acs.jmedchem.0c01845
Autor:
Danny V Jeyaraju, Maryam Alapa, Aimee O'Donohue, Ross La Motte-Mohs, Isaac W. Boss, Patrick Hagner, Michael Pourdehnad, Michael R. Burgess, William E. Pierceall, Anjan Thakurta
Publikováno v:
Blood. 140:7070-7071
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e701a1a20137e965cb14f0ba51773e4
https://doi.org/10.1182/blood-2022-157927
https://doi.org/10.1182/blood-2022-157927
Autor:
Steven J. Hartman, Ying Lu, Wentao Wei, Hao Zhou, Geoffrey Del Rosario, Robert A. Blake, Xiaoyu Zhu, Nicholas Corr, Aaron Fullerton, Shang-Fan Yu, Peter S. Dragovich, Jing Wang, Rebecca K. Rowntree, Donglu Zhang, Hui Yao, Emel Adaligil, Fan Jiang, Hongyan Zhang, Jack Sadowsky, John S. Wai, Jinhua Chen, Thomas H. Pillow, Susan Kaufman, Zijin Xu, Katherine R. Kozak, Jeremy Murray, Shenhua Zhang, Leanna Staben, Josefa dela Cruz-Chuh, Pragya Adhikari, Aimee O'Donohue, Tracy Kleinheinz, Liling Liu, Melinda M. Mulvihill, William S. Sawyer, Yongxin Zhao, Binqing Wei
Publikováno v:
Journal of medicinal chemistry. 64(5)
Heterobifunctional compounds that direct the ubiquitination of intracellular proteins in a targeted manner via co-opted ubiquitin ligases have enormous potential to transform the field of medicinal chemistry. These chimeric molecules, often termed pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519ca8bb4de4ed4b24ce14fe281e518e
https://pubmed.ncbi.nlm.nih.gov/33596073
https://pubmed.ncbi.nlm.nih.gov/33596073
Autor:
Douglas D. Leipold, Jinhua Chen, Aimee O'Donohue, Gang Yan, Zijin Xu, Shanique Martin, Gail Lewis Phillips, Josefa dela Cruz-Chuh, Thomas H. Pillow, Changrong He, Fang Fan, John S. Wai, Jintang He, Geoffrey Del Rosario, Carl Ng, Phillip Y. Chu, Shang-Fan Yu, Luna Liu, Dian Su, Guangmin Li, Keyang Xu, Yanli Wang, Katherine R. Kozak, Donglu Zhang, Hui Yao, Jack Sadowsky
Publikováno v:
Bioconjugate Chemistry. 28:2086-2098
Conjugation of small molecule payloads to cysteine residues on proteins via a disulfide bond represents an attractive strategy to generate redox-sensitive bioconjugates, which have value as potential diagnostic reagents or therapeutics. Advancement o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63f40b1323609c82d57231287fe6026
https://doi.org/10.1021/acs.bioconjchem.7b00258
https://doi.org/10.1021/acs.bioconjchem.7b00258
Autor:
Isabel Figueroa, Shang-Fan Yu, Hao Zhou, Ruina Li, Hongyan Zhang, Douglas D. Leipold, Peter S. Dragovich, Karen E. Gascoigne, Amrita V. Kamath, Thomas H. Pillow, Gauri Deshmukh, Pragya Adhikari, Jinhua Chen, John S. Wai, Xinxin Wang, Robert A. Blake, Richard Zang, Xiaoyu Zhu, Tracy Kleinheinz, Chun Sing Li, Donglu Zhang, Geoffrey Del Rosario, Rebecca K. Rowntree, Hui Yao, Melinda M. Mulvihill, Katherine R. Kozak, Jack Sadowsky, Susan Kaufman, Aimee O'Donohue, Cong Wu, Zijin Xu, Brandon Latifi
Publikováno v:
ChemMedChem. 15(1)
The ability to selectively degrade proteins with bifunctional small molecules has the potential to fundamentally alter therapy in a variety of diseases. However, the relatively large size of these chimeric molecules often results in challenging physi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::642f83b09ffafa4028e98f40e7d2947e
https://pubmed.ncbi.nlm.nih.gov/31674143
https://pubmed.ncbi.nlm.nih.gov/31674143
Autor:
John S. Wai, Richard Zang, Geoffrey Del Rosario, Rebecca K. Rowntree, Peter S. Dragovich, Ruina Li, Thomas H. Pillow, Gauri Deshmukh, Melinda M. Mulvihill, Xinxin Wang, Pragya Adhikari, Jinhua Chen, Amrita V. Kamath, Hao Zhou, Donglu Zhang, Isabel Figueroa, Shang-Fan Yu, Cong Wu, Chun Sing Li, Douglas D. Leipold, Hongyan Zhang, Hui Yao, Karen E. Gascoigne, Katherine R. Kozak, Brandon Latifi, Tracy Kleinheinz, Jack Sadowsky, Susan Kaufman, Robert A. Blake, Xiaoyu Zhu, Zijin Xu, Aimee O'Donohue
Publikováno v:
ChemMedChem. 15:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::239c9ef1276e5b4dc9029bc582161eca
https://doi.org/10.1002/cmdc.201900683
https://doi.org/10.1002/cmdc.201900683
Autor:
Suzie J. Scales, Josefa Chuh, Sarajane Ross, Elizabeth Luis, Susan D. Spencer, Mark S. Dennis, Glenn Pacheco, Yin Zhang, Jay Tibbitts, Jenny Bostrom, Nidhi Gupta, Dorothy French, Leanne Berry, Aimee O'Donohue, Ron Firestein, Katherine R. Kozak
Publikováno v:
Cancer Research. 74:4494-4494
Mesothelin (MSLN) is a cell surface glycoprotein widely expressed in a variety of cancers, with prevalence levels by IHC of 85% in ovarian, 75% in pancreatic and 45% in mesothelioma, and normal expression limited to the mesothelia, suggesting it coul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a626bf0a5d23e291c76169badf43a254
https://doi.org/10.1158/1538-7445.am2014-4494
https://doi.org/10.1158/1538-7445.am2014-4494