Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Aimee M. Guillotte"'
Autor:
Ramses Ayala, Sachin Hebbar, Bhavim Desai, Deanna S. Smith, Mariano T. Mesngon, Aimee M. Guillotte
Publikováno v:
The Journal of Cell Biology
Lis1 and Ndel1 are essential for animal development. They interact directly with one another and with cytoplasmic dynein. The developing brain is especially sensitive to reduced Lis1 or Ndel1 levels, as both proteins influence spindle orientation, ne
Autor:
Qin Zhou, Aimee M. Guillotte, Mariano T. Mesngon, Deanna S. Smith, Sachin Hebbar, Anthony Wynshaw-Boris
Publikováno v:
Developmental Neuroscience. 30:157-170
Hemizygous Lis1 mutations cause type 1 lissencephaly, a neuronal migration disorder in humans. The Lis1+/– mouse is a model for lissencephaly; mice exhibit neuronal migration defects but are viable and fertile. On an inbred genetic background, 20%
Autor:
Andrea Musacchio, Deanna S. Smith, Aimee M. Guillotte, Mariano T. Mesngon, Cataldo Tarricone, Sachin Hebbar, E. William Schmitt, Lorene M. Lanier, Stephen J. King
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(7)
Mutations in Lis1 cause classical lissencephaly, a developmental brain abnormality characterized by defects in neuronal positioning. Over the last decade, a clear link has been forged between Lis1 and the microtubule motor cytoplasmic dynein. Substan