Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Aimee L. Edinger"'
Autor:
Varvara I. Rubtsova, Yujin Chun, Joohwan Kim, Cuauhtemoc B. Ramirez, Sunhee Jung, Wonsuk Choi, Miranda E. Kelly, Miranda L. Lopez, Elizabeth Cassidy, Gabrielle Rushing, Dean J. Aguiar, Wei Ling Lau, Rebecca S. Ahdoot, Moyra Smith, Aimee L. Edinger, Sang-Guk Lee, Cholsoon Jang, Gina Lee
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110265- (2024)
Summary: Patients with tuberous sclerosis complex (TSC) develop multi-organ disease manifestations, with kidney angiomyolipomas (AML) and cysts being one of the most common and deadly. Early and regular AML/cyst detection and monitoring are vital to
Externí odkaz:
https://doaj.org/article/48a6a464373845dd830e00d9afe2fc57
Autor:
Vaishali Jayashankar, Aimee L. Edinger
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Macropinocytosis allows cancer cells to cope with nutrient stress. Here, the authors use a selective, genetic approach to inhibit macropinocytosis and show that consuming necrotic cell debris via macropinocytosis—necrocytosis—affords resistance t
Externí odkaz:
https://doaj.org/article/737b7cdd758c4542bc38e47261135578
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 4 (2018)
Our recent work demonstrates that inactivating mutations in phosphatase and tensin homolog (PTEN) are sufficient to drive macropinocytosis in the context of AMP-activated protein kinase (AMPK) activation. Given that blocking macropinocytosis limits P
Externí odkaz:
https://doaj.org/article/2872b03d7b724b5fa490ad9f03f9190d
Autor:
Brendan T Finicle, Kazumi H Eckenstein, Alexey S Revenko, Brooke A Anderson, W Brad Wan, Alison N McCracken, Daniel Gil, David A Fruman, Stephen Hanessian, Punit P Seth, Aimee L Edinger
Publikováno v:
Nucleic Acids Research. 51:1583-1599
Inefficient endosomal escape remains the primary barrier to the broad application of oligonucleotide therapeutics. Liver uptake after systemic administration is sufficiently robust that a therapeutic effect can be achieved but targeting extrahepatic
Autor:
Brendan T. Finicle, Cuauhtemoc Ramirez, Stephen Hanessian, Vito Vece, Sylvestre P J T Bachollet, Nadine Ben Romdhane, Elizabeth Selwan, Amogha Dahal, Alison N. McCracken, Aimee L. Edinger
Publikováno v:
ACS Med Chem Lett
[Image: see text] A synthetic sphingolipid related to a ring-constrained hydroxymethyl pyrrolidine analog of FTY720 that was known to starve cancer cells to death was chemically modified to include a series of alkoxy-tethered 3,6-substituted 1,2-pyri
Autor:
Nigel Turner, Amandine Verlande, Vaishali Jayashankar, Maggie O. Goodson, Giedre Milinkeviciute, Stephen Hanessian, Brianna M Hoover, Bin Chen, Selma Masri, Karina S. Cramer, Aimee L. Edinger, Elizabeth Selwan, Sarah E. Hancock, Kazumi Eckenstein, Angela G. Fleischman
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 13, Iss 8, Pp n/a-n/a (2021)
EMBO Molecular Medicine, Vol 13, Iss 8, Pp n/a-n/a (2021)
Ceramide‐induced mitochondrial fission drives high‐fat diet (HFD)‐induced obesity. However, molecules targeting mitochondrial dynamics have shown limited benefits in murine obesity models. Here, we reveal that these compounds are either unable
Publikováno v:
Nature Reviews Cancer. 18:619-633
While cancer cell proliferation depends on access to extracellular nutrients, inadequate tumour perfusion means that glucose, amino acids and lipids are often in short supply. To overcome this obstacle to growth, cancer cells utilize multiple scaveng
Autor:
William G. Kaelin, Jennifer Cable, Ralph J. DeBerardinis, Gary J. Patti, Sanika Khare, Marcia C. Haigis, Russell Ericksen, Trudy G. Oliver, Benjamin P. Tu, Lydia W.S. Finley, Santosha Vardhana, Brent R. Stockwell, Aimee L. Edinger, Miyeko D. Mana
Publikováno v:
Ann N Y Acad Sci
Tumor cells have devised unique metabolic strategies to garner enough nutrients to sustain continuous growth and cell division. Oncogenic mutations may alter metabolic pathways to unlock new sources of energy, and cells take the advantage of various
Autor:
Seong M. Kim, Pierre Thibault, Brendan T. Finicle, Dong Gao, Michelle A. Digman, Leonel Malacrida, Jue Hou, Aimee L. Edinger, Vaishali Jayashankar, Jane Robertson, Jonathan Chernoff, Bruce J. Tromberg, Archna Ravi, Peter Kubiniok, Eric O. Potma, Tricia T. Nguyen
Publikováno v:
Cancer discovery, vol 8, iss 7
We report that PTEN-deficient prostate cancer cells use macropinocytosis to survive and proliferate under nutrient stress. PTEN loss increased macropinocytosis only in the context of AMPK activation, revealing a general requirement for AMPK in macrop
Autor:
Aimee L. Edinger, Elizabeth Selwan
Publikováno v:
Translational Cancer Research. 6:S578-S584
Because non-homeostatic proliferation increases anabolic demand, tumor cells reprogram metabolism in ways that support growth. Although tumor cells retain some metabolic flexibility, the constitutive activation of oncogenes and mutation or loss of tu