Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Aimee K Zaas"'
Autor:
Christopher W Woods, Ricardo Henao, Geoffrey S Ginsburg, Ephraim L Tsalik, Matthew McCravy, Nicholas O’Grady, Kirin Khan, Marisol Betancourt-Quiroz, Aimee K Zaas, Amy E Treece, Zhonghui Yang, Loretta Que, Sunil Suchindran, Micah T McClain
Publikováno v:
BMJ Open Respiratory Research, Vol 11, Iss 1 (2024)
Background Pneumonia due to typical bacterial, atypical bacterial and viral pathogens can be difficult to clinically differentiate. Host response-based diagnostics are emerging as a complementary diagnostic strategy to pathogen detection.Methods We u
Externí odkaz:
https://doaj.org/article/94264de395084613903bd2ca92ca1866
Autor:
Jason J Rose, Deepak Voora, Derek D Cyr, Joseph E Lucas, Aimee K Zaas, Christopher W Woods, L Kristin Newby, William E Kraus, Geoffrey S Ginsburg
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132259 (2015)
Influenza infection is associated with myocardial infarction (MI), suggesting that respiratory viral infection may induce biologic pathways that contribute to MI. We tested the hypotheses that 1) a validated blood gene expression signature of respira
Externí odkaz:
https://doaj.org/article/ece649411e3d44d3a244a5408d67cb4a
Autor:
Christopher W Woods, Micah T McClain, Minhua Chen, Aimee K Zaas, Bradly P Nicholson, Jay Varkey, Timothy Veldman, Stephen F Kingsmore, Yongsheng Huang, Robert Lambkin-Williams, Anthony G Gilbert, Alfred O Hero, Elizabeth Ramsburg, Seth Glickman, Joseph E Lucas, Lawrence Carin, Geoffrey S Ginsburg
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e52198 (2013)
There is great potential for host-based gene expression analysis to impact the early diagnosis of infectious diseases. In particular, the influenza pandemic of 2009 highlighted the challenges and limitations of traditional pathogen-based testing for
Externí odkaz:
https://doaj.org/article/dfa93b3d53ac4136ac04375cfd974d78
Autor:
Sun Hee Ahn, Ephraim L Tsalik, Derek D Cyr, Yurong Zhang, Jennifer C van Velkinburgh, Raymond J Langley, Seth W Glickman, Charles B Cairns, Aimee K Zaas, Emanuel P Rivers, Ronny M Otero, Tim Veldman, Stephen F Kingsmore, Joseph Lucas, Christopher W Woods, Geoffrey S Ginsburg, Vance G Fowler
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e48979 (2013)
Staphylococcus aureus causes a spectrum of human infection. Diagnostic delays and uncertainty lead to treatment delays and inappropriate antibiotic use. A growing literature suggests the host's inflammatory response to the pathogen represents a poten
Externí odkaz:
https://doaj.org/article/8b7bdab08eb242da8f6a8dd9d8b90b8d
Autor:
Kimberly E Hanson, Christopher D Pfeiffer, Erika D Lease, Alfred H Balch, Aimee K Zaas, John R Perfect, Barbara D Alexander
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42282 (2012)
Invasive candidiasis (IC) is a devastating disease. While prompt antifungal therapy improves outcomes, empiric treatment based on the presence of fever has little clinical impact. Β-D-Glucan (BDG) is a fungal cell wall component detectable in the se
Externí odkaz:
https://doaj.org/article/dc5ae76b73204dd0ab2cef1a4abcfc01
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44734 (2012)
The molecular chaperone Hsp90 orchestrates regulatory circuitry governing fungal morphogenesis, biofilm development, drug resistance, and virulence. Hsp90 functions in concert with co-chaperones to regulate stability and activation of client proteins
Externí odkaz:
https://doaj.org/article/c60ed2a340734c3a93c37684141b8ed8
Autor:
Yongsheng Huang, Aimee K Zaas, Arvind Rao, Nicolas Dobigeon, Peter J Woolf, Timothy Veldman, N Christine Øien, Micah T McClain, Jay B Varkey, Bradley Nicholson, Lawrence Carin, Stephen Kingsmore, Christopher W Woods, Geoffrey S Ginsburg, Alfred O Hero
Publikováno v:
PLoS Genetics, Vol 7, Iss 8, p e1002234 (2011)
Exposure to influenza viruses is necessary, but not sufficient, for healthy human hosts to develop symptomatic illness. The host response is an important determinant of disease progression. In order to delineate host molecular responses that differen
Externí odkaz:
https://doaj.org/article/f42f3929dd564c77bdb211289c0a5869
Autor:
Sun-Hee Ahn, Hitesh Deshmukh, Nicole Johnson, Lindsay G Cowell, Thomas H Rude, William K Scott, Charlotte L Nelson, Aimee K Zaas, Douglas A Marchuk, Sehoon Keum, Supaporn Lamlertthon, Batu K Sharma-Kuinkel, Gregory D Sempowski, Vance G Fowler
Publikováno v:
PLoS Pathogens, Vol 6, Iss 9, p e1001088 (2010)
Although it has recently been shown that A/J mice are highly susceptible to Staphylococcus aureus sepsis as compared to C57BL/6J, the specific genes responsible for this differential phenotype are unknown. Using chromosome substitution strains (CSS),
Externí odkaz:
https://doaj.org/article/e6a601f93f0544b0b45c7f1f080ef252
Autor:
Shantelle L LaFayette, Cathy Collins, Aimee K Zaas, Wiley A Schell, Marisol Betancourt-Quiroz, A A Leslie Gunatilaka, John R Perfect, Leah E Cowen
Publikováno v:
PLoS Pathogens, Vol 6, Iss 8, p e1001069 (2010)
Fungal pathogens exploit diverse mechanisms to survive exposure to antifungal drugs. This poses concern given the limited number of clinically useful antifungals and the growing population of immunocompromised individuals vulnerable to life-threateni
Externí odkaz:
https://doaj.org/article/4a3fa07504f64bd1816fc6d3d9ba11ea
Publikováno v:
PLoS Pathogens, Vol 5, Iss 7, p e1000532 (2009)
Candida albicans is the leading fungal pathogen of humans, causing life-threatening disease in immunocompromised individuals. Treatment of candidiasis is hampered by the limited number of antifungal drugs whose efficacy is compromised by host toxicit
Externí odkaz:
https://doaj.org/article/570aafdb3251477a94eddf6c40262878