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pro vyhledávání: '"Aimee Hillegas"'
Development of an Improved T-cell Assay to Assess the Intrinsic Immunogenicity of Haptenic Compounds
Autor:
Joel Watkinson, Melanie Z. Sakatis, Monday O. Ogese, Brian Kevin Park, Dean J. Naisbitt, Adam Lister, Lee Faulkner, Andrew Gibson, Aimee Hillegas
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology
The prediction of drug hypersensitivity is difficult due to the lack of appropriate models and known risk factors. In vitro naïve T-cell priming assays that assess immunogenicity have been developed. However, their application is limited due require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e56eca85252027716f1816875dba21e
Autor:
Victoria Weller, Poonam Shah, David N. Mallett, Mark Price, Joanne O. Hessey, Diane M. Coe, Stephen C. Hughes, Charlotte J. Hardy, Amanda Lucas, Xiao Qing Lewell, Doug Ball, Bob H. Gibbon, Stephen A. Smith, Anesh Sitaram, Linos Lazarides, Keith Biggadike, Daphne Tsitoura, Stephen A. Hermitage, Richard Stocker, Chris D. Edwards, Mahbub Ahmed, Diana Quint, Fiona Priest, Deidre Dalmas Wilk, Aimee Hillegas, Naimisha Trivedi
Publikováno v:
Journal of medicinal chemistry. 59(5)
Induction of IFNα in the upper airways via activation of TLR7 represents a novel immunomodulatory approach to the treatment of allergic asthma. Exploration of 8-oxoadenine derivatives bearing saturated oxygen or nitrogen heterocycles in the N-9 subs