Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Aimee Fourie"'
Autor:
Nicholas Vance, Neelie Zacharias, Mark Ultsch, Guangmin Li, Aimee Fourie, Peter Liu, Julien LaFrance-Vanasse, James A. Ernst, Wendy Sandoval, Katherine R. Kozak, Gail Phillips, Weiru Wang, Jack Sadowsky
Publikováno v:
Bioconjugate chemistry. 30(1)
Site-specific conjugation of small molecules to antibodies represents an attractive goal for the development of more homogeneous targeted therapies and diagnostics. Most site-specific conjugation strategies require modification or removal of antibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ca2f0a00e1caf74a5840b230121d29
https://pubmed.ncbi.nlm.nih.gov/30566343
https://pubmed.ncbi.nlm.nih.gov/30566343
Autor:
Peter S. Dragovich, Keyang Xu, John S. Wai, Jason Oeh, Willem den Besten, Yong Ma, Richard Vandlen, Ellen Ingalla, Fang Fan, Ingrid E. Wertz, Chunjiao Chen, Steven R. Leong, Deepak Sampath, Jiawei Lu, Donglu Zhang, Katherine R. Kozak, Thomas H. Pillow, Steven J. Hartman, Breanna S. Vollmar, Changrong He, Zijin Xu, Robert A. Blake, Gail Lewis Phillips, Josefa Chuh, Rebecca K. Rowntree, Jinhua Chen, Michelle Nannini, Rachana Ohri, Jintang He, Aimee Fourie, Lingyao Meng
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 24(19)
A novel strategy to attach indole-containing payloads to antibodies through a carbamate moiety and a self-immolating, disulfide-based linker is described. This new strategy was employed to connect a selective estrogen receptor down-regulator (SERD) t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017ee13e19eaac5efc51623fb581c8c3
https://pubmed.ncbi.nlm.nih.gov/29493023
https://pubmed.ncbi.nlm.nih.gov/29493023
Autor:
C. Andrew Boswell, Kedan Lin, Paul Polakis, Crystal Zhang, Ron Firestein, Herman Gill, Shannon Stainton, Eduardo E. Mundo, Sheila Ulufatu, Leslie A. Khawli, Nina Ljumanovic, Reina N. Fuji, Cynthia Young, Aimee Fourie, Katherine R. Kozak, Weiguang Mao
Publikováno v:
British Journal of Pharmacology. 168:445-457
Background and Purpose The success of antibody-drug conjugates (ADCs) depends on the therapeutic window rendered by the differential expression between normal and pathological tissues. The ability to identify and visualize target expression in normal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::555c418c363b2e13ed831ee4b7da2ec4
https://doi.org/10.1111/j.1476-5381.2012.02138.x
https://doi.org/10.1111/j.1476-5381.2012.02138.x
Autor:
C. Andrew Boswell, Aimee Fourie, Eduardo E. Mundo, Paul Polakis, Leslie A. Khawli, Crystal Zhang, Shang-Fan Yu, Weiguang Mao, Katherine R. Kozak, Jennifer A. Lacap, Shannon Stainton, Kedan Lin
Publikováno v:
Journal of Nuclear Medicine. 53:1454-1461
TENB2, also known as tomoregulin or transmembrane protein with epidermal growth factor–like and 2 follistatin-like domains, is a transmembrane proteoglycan overexpressed in human prostate tumors. This protein is a promising target for antimitotic m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a0029b0e73d04cc5b56fb068fb96cb
https://doi.org/10.2967/jnumed.112.103168
https://doi.org/10.2967/jnumed.112.103168
Autor:
Surinder Kaur, Herman Gill, Ben-Quan Shen, Neelima Koppada, Nicole Valle, Kedan Lin, Aimee Fourie, Katherine R. Kozak, Crystal Zhang, Jay Tibbitts, Ola Saad, Paul J. Fielder, Josefa Chuh, Bonnee Rubinfeld, Eduardo E. Mundo, Leslie A. Khawli, Daniela Bumbaca, Frank-Peter Theil, C. Andrew Boswell
Publikováno v:
Bioconjugate chemistry. 22(10)
Antibody-drug conjugates (ADCs) are designed to combine the exquisite specificity of antibodies to target tumor antigens with the cytotoxic potency of chemotherapeutic drugs. In addition to the general chemical stability of the linker, a thorough und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da488a7484db0a75dddd39e9f057453
https://pubmed.ncbi.nlm.nih.gov/21913715
https://pubmed.ncbi.nlm.nih.gov/21913715
Autor:
Aimee Fourie, An Do, Yulei Wang, Kathy Kozak, Suzie J. Scales, Lisa Ryner, Ron Firestein, Siao Ping Tsai, Yinghui Guan
Publikováno v:
Cancer Research. 73:3213-3213
MUC16 and MSLN are tumor-specific antigens highly prevalent in ovarian and pancreatic cancers and have been used as targets in developing antibody-drug conjugates (ADCs). Development of a sensitive method to quantitatively measure these protein bioma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95f42dc9d8b8d1ad3d061040300f6766
https://doi.org/10.1158/1538-7445.am2013-3213
https://doi.org/10.1158/1538-7445.am2013-3213
Autor:
Aimee Fourie-O’Donohue, Phillip Y. Chu, Josefa dela Cruz Chuh, Robert Tchelepi, Siao Ping Tsai, John C. Tran, William S. Sawyer, Dian Su, Carl Ng, Keyang Xu, Shang-Fan Yu, Thomas H. Pillow, Jack Sadowsky, Peter S. Dragovich, Yichin Liu, Katherine R. Kozak
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
For antibody-drug conjugates to be efficacious and safe, they must be stable in circulation to carry the payload to the site of the targeted cell. Several components of a drug-conjugated antibody are known to influence stability: 1) the site of drug
Externí odkaz:
https://doaj.org/article/e46e20ec184a4063ba55b87d5b9f2d28
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