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of 4
pro vyhledávání: '"Aimee E. Mattei"'
Autor:
Aimee E. Mattei, Andres H. Gutierrez, Soorya Seshadri, Jacob Tivin, Matt Ardito, Amy S. Rosenberg, William D. Martin, Anne S. De Groot
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTIn silico immunogenicity risk assessment has been an important step in the development path for many biologic therapeutics, including monoclonal antibodies. Even if the source of a given biologic is ‘fully human’, T cell epitopes that are
Externí odkaz:
https://doaj.org/article/d3ac97f35912434aae9b77e2b10534c0
Autor:
Brian J. Roberts, Aimee E. Mattei, Kristina E. Howard, James L. Weaver, Hao Liu, Sandra Lelias, William D. Martin, Daniela Verthelyi, Eric Pang, Katie J. Edwards, Anne S. De Groot
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Advances in synthetic peptide synthesis have enabled rapid and cost-effective peptide drug manufacturing. For this reason, peptide drugs that were first produced using recombinant DNA (rDNA) technology are now being produced using solid- and liquid-p
Externí odkaz:
https://doaj.org/article/674dd4b85a844bff9f2eb55deb7c7e13
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Biologics developers are moving beyond antibodies for delivery of a wide range of therapeutic interventions. These non-antibody modalities are often based on ‘natural’ protein scaffolds that are modified to deliver bioactive sequences. Both human
Externí odkaz:
https://doaj.org/article/fb0855ea9b154b43a5269a481f59c86f
Autor:
Aimee E. Mattei, Andres H. Gutierrez, William D. Martin, Frances E. Terry, Brian J. Roberts, Amy S. Rosenberg, Anne S. De Groot
Publikováno v:
Front Drug Discov (Lausanne)
Thein silicoprediction of T cell epitopes within any peptide or biologic drug candidate serves as an important first step for assessing immunogenicity. T cell epitopes bind human leukocyte antigen (HLA) by a well-characterized interaction of amino ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2baaa46b957845b176edb5c7c9f65bbd
https://doi.org/10.3389/fddsv.2022.952326
https://doi.org/10.3389/fddsv.2022.952326