Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Aimee D Shu"'
Autor:
Sun Moon Kim, Aimee D Shu, Jin Long, Maria E Montez-Rath, Mary B Leonard, Jeffrey A Norton, Glenn M Chertow
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161192 (2016)
Parathyroidectomy is the only curative therapy for patients with primary hyperparathyroidism. However, the incidence, correlates and consequences of parathyroidectomy for primary hyperparathyroidism across the entire US population are unknown. We eva
Externí odkaz:
https://doaj.org/article/2f6c3067fbb442f9a6724106698cb62c
Autor:
Ravi Savarirayan, Daniel G. Hoernschemeyer, Merete Ljungberg, Yuri A. Zarate, Carlos A. Bacino, Michael B. Bober, Janet M. Legare, Wolfgang Högler, Teresa Quattrin, M. Jennifer Abuzzahab, Paul L. Hofman, Klane K. White, Nina S. Ma, Dirk Schnabel, Sérgio B. Sousa, Meng Mao, Alden Smith, Mukta Chakraborty, Adebola Giwa, Bent Winding, Birgitte Volck, Aimee D. Shu, Ciara McDonnell
Publikováno v:
EClinicalMedicine, Vol 65, Iss , Pp 102258- (2023)
Summary: Background: TransCon CNP (navepegritide) is an investigational prodrug of C-type natriuretic peptide (CNP) designed to allow for continuous CNP exposure with once-weekly dosing. This 52-week phase 2 (ACcomplisH) trial assessed the safety and
Externí odkaz:
https://doaj.org/article/07498b64dfd0403e9988b282f640b406
Publikováno v:
Quality of Life Research. 32:1795-1806
Purpose The purpose of this study was to conduct cognitive debriefing (CD) interviews with adults diagnosed with chronic hypoparathyroidism (HP) to assess the content validity of the SF-36v2® Health Survey Acute (SF-36v2) measure in this population.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5fb843b85572078d713c621e813c1bf
https://doi.org/10.1007/s11136-023-03352-x
https://doi.org/10.1007/s11136-023-03352-x
Autor:
Aliya A Khan, Mishaela R Rubin, Peter Schwarz, Tamara Vokes, Dolores M Shoback, Claudia Gagnon, Andrea Palermo, Claudio Marcocci, Bart L Clarke, Lisa G Abbott, Lorenz C Hofbauer, Lynn Kohlmeier, Susanne Pihl, Xuebei An, Walter Frank Eng, Alden R Smith, Jenny Ukena, Christopher T Sibley, Aimee D Shu, Lars Rejnmark
Publikováno v:
Khan, A A, Rubin, M R, Schwarz, P, Vokes, T, Shoback, D M, Gagnon, C, Palermo, A, Marcocci, C, Clarke, B L, Abbott, L G, Hofbauer, L C, Kohlmeier, L, Pihl, S, An, X, Eng, W F, Smith, A R, Ukena, J, Sibley, C T, Shu, A D & Rejnmark, L 2023, ' Efficacy and Safety of Parathyroid Hormone Replacement With TransCon PTH in Hypoparathyroidism : 26-Week Results From the Phase 3 PaTHway Trial ', Journal of Bone and Mineral Research, vol. 38, no. 1, pp. 14-25 . https://doi.org/10.1002/jbmr.4726
Conventional therapy for hypoparathyroidism consisting of active vitamin D and calcium aims to alleviate hypocalcemia but fails to restore normal parathyroid hormone (PTH) physiology. PTH replacement therapy is the ideal physiologic treatment for hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598c72df8edf4f71a1305314e63ef0e2
https://pure.au.dk/portal/da/publications/efficacy-and-safety-of-parathyroid-hormone-replacement-with-transcon-pth-in-hypoparathyroidism(e24e64f1-bec4-43b6-9e7e-c0510d90c590).html
https://pure.au.dk/portal/da/publications/efficacy-and-safety-of-parathyroid-hormone-replacement-with-transcon-pth-in-hypoparathyroidism(e24e64f1-bec4-43b6-9e7e-c0510d90c590).html
Autor:
Peter Schwarz, Denka Markova, Alden Smith, Sanchita Mourya, Lars Rejnmark, Aimee D Shu, Intekhab Ahmed, David B Karpf, Tamara Vokes, Aliya Khan, Claudio Marcocci, Bart L. Clarke, Meryl Brod, Erik Fink Eriksen, Mishaela R. Rubin, Susanne Pihl, Uberto Pagotto, Andrea Palermo, Lorenz C. Hofbauer
Publikováno v:
Khan, A A, Rejnmark, L, Rubin, M, Schwarz, P, Vokes, T, Clarke, B, Ahmed, I, Hofbauer, L, Marcocci, C, Pagotto, U, Palermo, A, Eriksen, E, Brod, M, Markova, D, Smith, A, Pihl, S, Mourya, S, Karpf, D B & Shu, A D 2022, ' PaTH Forward : A Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial of TransCon PTH in Adult Hypoparathyroidism ', Journal of Clinical Endocrinology and Metabolism, vol. 107, no. 1, pp. E372-E385 . https://doi.org/10.1210/clinem/dgab577
The Journal of Clinical Endocrinology and Metabolism
The Journal of Clinical Endocrinology and Metabolism
Context Hypoparathyroidism is characterized by insufficient levels of parathyroid hormone (PTH). TransCon PTH is an investigational long-acting prodrug of PTH(1-34) for the treatment of hypoparathyroidism. Objective This work aimed to investigate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c2cf0348e82835f0ff0a5670103b0b
https://curis.ku.dk/portal/da/publications/path-forward(e72390ee-4276-41d2-8b23-5d120efae605).html
https://curis.ku.dk/portal/da/publications/path-forward(e72390ee-4276-41d2-8b23-5d120efae605).html
Autor:
Aristides K Maniatis, Samuel J Casella, Ulhas M Nadgir, Paul L Hofman, Paul Saenger, Elena D Chertock, Elena M Aghajanova, Maria Korpal-Szczyrska, Elpis Vlachopapadopoulou, Oleg Malievskiy, Tetyana Chaychenko, Marco Cappa, Wenjie Song, Meng Mao, Per Holse Mygind, Alden R Smith, Steven D Chessler, Allison S Komirenko, Michael Beckert, Aimee D Shu, Paul S Thornton
Publikováno v:
The Journal of clinical endocrinology and metabolism. 107(7)
Purpose The objectives of the ongoing, Phase 3, open-label extension trial enliGHten are to assess the long-term safety and efficacy of weekly administered long-acting growth hormone lonapegsomatropin in children with growth hormone deficiency. Metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265b429f9e88e65a20a36daf9f9774cd
https://pubmed.ncbi.nlm.nih.gov/35428884
https://pubmed.ncbi.nlm.nih.gov/35428884
Publikováno v:
Journal of the Endocrine Society
Context Serum insulin-like growth factor 1 (IGF-1) levels are relatively constant in somatropin-treated children with growth hormone deficiency (GHD), and guide dose adjustments for clinical efficacy and long-term safety. IGF-1 levels following treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4883deeaccaedcf05f941d89d11ab861
https://doi.org/10.1210/jendso/bvab168
https://doi.org/10.1210/jendso/bvab168
Autor:
Aristides K. Maniatis, Ulhas Nadgir, Paul Saenger, Kent L. Reifschneider, Jennifer Abuzzahab, Larry Deeb, Larry A. Fox, Katie A. Woods, Wenjie Song, Meng Mao, Steven D. Chessler, Allison S. Komirenko, Aimee D. Shu, Samuel J. Casella, Paul S. Thornton
Publikováno v:
Hormone research in paediatrics. 95(3)
Introduction: The phase 3 fliGHt Trial evaluated the safety and tolerability of once-weekly lonapegsomatropin, a long-acting prodrug, in children with growth hormone deficiency (GHD) who switched from daily somatropin therapy to lonapegsomatropin. Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e97f09cd230e8fa694c367e8a58be5
https://pubmed.ncbi.nlm.nih.gov/35263755
https://pubmed.ncbi.nlm.nih.gov/35263755
Autor:
Paul Saenger, Ulhas Nadgir, Paul Hofman, Paul Thornton, Elena D Chertok, Elena M Aghajanova, Maria Korpal-Szczyrska, Elpis Vlachopapadopoulou, Oleg Malievskiy, Tetyana Chaychenko, Marco Cappa, Wenjie Song, Meng Mao, Steven D Chessler, Allison S Komirenko, Michael Beckert, Aimee D Shu, Aristides K Maniatis
Publikováno v:
Journal of the Endocrine Society. 6:A645-A645
Background Once-weekly lonapegsomatropin (TransCon hGH) is a long-acting prodrug of somatropin, recently approved for the treatment of pediatric growth hormone deficiency (GHD) by the US FDA. In the pivotal 52-week phase 3 heiGHt trial and the 26-wee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2331a24785a2da58c53d2ed97ab1f12
https://doi.org/10.1210/jendso/bvac150.1334
https://doi.org/10.1210/jendso/bvac150.1334
Autor:
Paul S Thornton, Aristides K Maniatis, Elena Aghajanova, Elena Chertok, Zhengning Lin, Wenjie Song, Eva Dam Christoffersen, Vibeke Miller Breinholt, Elene Giorgadze, Maria Korpal-Szczyrska, Paul L Hofman, David B Karpf, Aimee D Shu, Michael Beckert
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 107:e2215-e2216
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8856483edef99b7029ac651b88b30e1
https://doi.org/10.1210/clinem/dgab879
https://doi.org/10.1210/clinem/dgab879