Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Aiman S El-Khatib"'
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 9, Pp 1913-1918 (2022)
Numerous molecular mechanisms are being examined in an attempt to discover disease-modifying drugs to slow down the underlying neurodegeneration in Alzheimer’s disease. Recent studies have shown the beneficial effects of epidermal growth factor rec
Externí odkaz:
https://doaj.org/article/58bc787852664029910002ac37395eeb
Autor:
Andrew N. Hakeem, Mohamed M. Kamal, Rasha A. Tawfiq, Basma A. Abdelrahman, Olfat A. Hammam, Mohamed M. Elmazar, Aiman S. El-Khatib, Yasmeen M. Attia
Publikováno v:
Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 157
Experimental and clinical evidence implicate disrupted gut barrier integrity in provoking innate immune responses, specifically macrophages, towards the progression of non-alcoholic steatohepatitis (NASH). Peroxisome proliferator-activated receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c09ff2f813e2d42ad783c9a5588f67
https://pubmed.ncbi.nlm.nih.gov/36462310
https://pubmed.ncbi.nlm.nih.gov/36462310
Publikováno v:
Canadian journal of physiology and pharmacology. 100(9)
Histone deacetylase inhibitors (HDACIs) act as antiproliferative agents by promoting differentiation and inducing apoptosis. Valproic acid (VPA) is a HDACI that shows promising chemotherapeutic effect in a number of tumor cells. The present study aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc7a63b2c975cda28a98fe8f48089c2
https://pubmed.ncbi.nlm.nih.gov/35679619
https://pubmed.ncbi.nlm.nih.gov/35679619
Publikováno v:
Ageing Research Reviews. 85:101841
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder in the world. Motor impairment seen in PD is associated with dopaminergic neurotoxicity in the striatum, and dopaminergic neuronal death in the substantia nigra pars com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef01ff1c88cf95f9d144fff234f69724
https://doi.org/10.1016/j.arr.2022.101841
https://doi.org/10.1016/j.arr.2022.101841
Publikováno v:
Neurochemistry international. 150
Mitochondrial, autophagic impairment, excitotoxicity, and also neuroinflammation are implicated in Alzheimer's disease (AD) pathophysiology. We postulated that inhibiting the mitochondrial pyruvate carrier-1 (MPC-1), which inhibits the activation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3db1fdf0d86dd60e552780721161f37
https://pubmed.ncbi.nlm.nih.gov/34481907
https://pubmed.ncbi.nlm.nih.gov/34481907
Autor:
Sahar S. Abd El-Rahman, Omneya O Galal, Lobna A Abdelwahab, Aiman S. El-Khatib, Mahmoud M. Khattab, Amany I El-Brairy
Publikováno v:
Biologicalpharmaceutical bulletin. 44(10)
Oxytocin (OXT) -"the love hormone"- has been involved in the anti-depressant activity of some selective serotonin reuptake inhibitors (SSRIs). The exact mechanism underlying the OXT pathway in depression is not fully clear. This study aimed to invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d996119a555e84bfa48a01dd22c23b2e
https://pubmed.ncbi.nlm.nih.gov/34349049
https://pubmed.ncbi.nlm.nih.gov/34349049
Publikováno v:
Neuroscience.
Clinical trials of new drugs for Alzheimer’s disease (AD) have ended with disappointing results, with tremendous resources and time. Repositioning of existing anti-cancer epidermal growth factor receptors (EGFR) inhibitors in various preclinical AD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82db390bdccbeba848c65718057c71ea
https://doi.org/10.1016/j.neuroscience.2021.06.013
https://doi.org/10.1016/j.neuroscience.2021.06.013
Autor:
Zeinab M. Awwad, Shaimaa M Khedr, Mahmoud M. Khattab, Ahmed I. Elmallah, Samar O. El-Ganainy, Aiman S. El-Khatib
Publikováno v:
Cardiovascular Toxicology. 20:301-311
Pregabalin (PRG) possesses great therapeutic benefits in the treatment of epilepsy, neuropathic pain, and fibromyalgia. However, clinical data have reported incidence or exacerbation of heart failure following PRG administration. Experimental data ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5ac377015ea39c736cec21f2d711c0
https://doi.org/10.1007/s12012-019-09553-6
https://doi.org/10.1007/s12012-019-09553-6
Autor:
Samar O. El-Ganainy, Aiman S. El-Khatib, Mahmoud M. Khattab, Ahmed I. Elmallah, Dina Abdallah, Mahmoud M. Mohy El-Din
Publikováno v:
Toxicology Letters. 305:58-64
Myopathy is a well-known adverse effect of statins, affecting a large sector of statins users. The reported experimental data emphasized on mechanistic study of statin myopathy on large muscles. Clinically, both large muscles and respiratory muscles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feea7eb6132c27151d4258a4afcf08cc
https://doi.org/10.1016/j.toxlet.2019.02.001
https://doi.org/10.1016/j.toxlet.2019.02.001
Publikováno v:
Life Sciences. 222:245-254
Background Phosphodiestrase (PDE) enzymes are suggested to play a leading role in fibrogenesis of liver where studies showed the possible implication of PDE 1 & 4 in liver injury proposing them as possible targets for treating liver fibrosis. Aim The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e71ea52939e8a61a9541f3131850e6
https://doi.org/10.1016/j.lfs.2019.03.014
https://doi.org/10.1016/j.lfs.2019.03.014