Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Aimalie Hardaway"'
Autor:
Di Cui, Jianneng Li, Ziqi Zhu, Michael Berk, Aimalie Hardaway, Jeffrey McManus, Yoon-Mi Chung, Mohammad Alyamani, Shelley Valle, Ritika Tiwari, Bangmin Han, Maryam Goudarzi, Belinda Willard, Nima Sharifi
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 7 (2023)
After androgen deprivation, prostate cancer frequently becomes castration resistant (CRPC), with intratumoral androgen production from extragonadal precursors that activate the androgen receptor pathway. 3β-Hydroxysteroid dehydrogenase-1 (3βHSD1) i
Externí odkaz:
https://doaj.org/article/35efcccf9f7f4527b57a4702b4953aac
Autor:
Megan L. Kruse, Mona Patel, Jeffrey McManus, Yoon-Mi Chung, Xiuxiu Li, Wei Wei, Peter S. Bazeley, Fumihiko Nakamura, Aimalie Hardaway, Erinn Downs, Sarat Chandarlapaty, Mathew Thomas, Halle C.F. Moore, George T. Budd, W.H. Wilson Tang, Stanley L. Hazen, Aaron Bernstein, Serena Nik-Zainal, Jame Abraham, Nima Sharifi
Publikováno v:
JCI Insight, Vol 6, Iss 20 (2021)
BACKGROUND Genetics of estrogen synthesis and breast cancer risk has been elusive. The 1245A→C missense-encoding polymorphism in HSD3B1, which is common in White populations, is functionally adrenal permissive and increases synthesis of the aromata
Externí odkaz:
https://doaj.org/article/5d4adf6bdf6f4dbfb12d6380de88f28d
Autor:
Jonathan D. Smith, Kailash Gulshan, Nima Sharifi, J. Mark Brown, Emmanuel Opoku, Jennifer Major, Hanxu Lu, Shuhui Wang Lorkowski, C. Alicia Traughber, Gregory Brubaker, Aimalie Hardaway, Yoon-Mi Chung, Chase K.A. Neumann
Publikováno v:
J Biol Chem
High-density lipoprotein (HDL) metabolism is facilitated in part by scavenger receptor class B, type 1 (SR-B1) that mediates HDL uptake into cells. Higher levels of HDL have been associated with protection in other diseases, however, its role in pros
Autor:
Stanley L. Hazen, Nima Sharifi, Fumihiko Nakamura, Mona Patel, Xiuxiu Li, Erinn Downs, Yoon-Mi Chung, Peter Bazeley, Aaron C Bernstein, Sarat Chandarlapaty, Aimalie Hardaway, Halle C. F. Moore, Wei Wei, Serena Nik-Zainal, George Thomas Budd, Jeffrey M. McManus, Jame Abraham, Mathew Thomas, Megan L. Kruse, W.H. Wilson Tang
Publikováno v:
JCI Insight
BACKGROUND Genetics of estrogen synthesis and breast cancer risk has been elusive. The 1245A→C missense-encoding polymorphism in HSD3B1, which is common in White populations, is functionally adrenal permissive and increases synthesis of the aromata
Autor:
Shinjini Ganguly, Zaeem Lone, Andrew Muskara, Anna Kondratova, Anthony Ghanem, Yoon-Mi Chung, Aimalie Hardaway, Monaben Patel, Elai Davicioni, Shilpa Gupta, Jay Ciezki, Jorge Garcia, Kevin Stephans, Rahul Tendulkar, Eric Klien, Nima Sharifi, Omar Y. Mian
Publikováno v:
Journal of the National Comprehensive Cancer Network. 20:YIA22-002
Autor:
Jonathan D. Smith, Jennifer Major, Aimalie Hardaway, Kailash Gulshan, Emmanuel Opoku, Gregory Brubaker, Nima Sharifi, C. Alicia Traughber, Hanxu Lu, Yoon-Mi Chung, Shuhui Wang Lorkowski, Chase K.A. Neumann, J. Mark Brown
High density lipoprotein (HDL) metabolism, in part, is facilitated by scavenger receptor class B, type 1 (SR-B1) that mediates its uptake into cells. SR-B1 is upregulated in prostate cancer tissue. Here, we report that knockout (KO) of SR-B1 via CRIS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66bddb0092f8c0c37f14e263597c08e5
https://doi.org/10.1101/2020.02.24.963454
https://doi.org/10.1101/2020.02.24.963454
Autor:
Fumihiko Nakamura, Jame Abraham, Nima Sharifi, Jeffrey M McManus, Wei Wei, Stanley L. Hazen, W.H. Wilson Tang, Serena Nik-Zainal, Aaron C Bernstein, Megan L. Kruse, Yoon-Mi Chung, Sarat Chandarlapaty, Erinn Downs Kelley, Aimalie Hardaway, Halle C. F. Moore, George Thomas Budd, Mathew Thomas, Peter Bazeley
Publikováno v:
Journal of Clinical Oncology. 39:10503-10503
10503 Background: Genetic factors that contribute to endogenous estrogen synthesis and postmenopausal breast cancer risk are unknown. We set out to test the hypothesis that homozygous inheritance of the common 1245A→C missense-encoding polymorphism
Autor:
Aimalie Hardaway, Aysegul Balyimez, Rahul D. Tendulkar, Zaeem Lone, E.A. Klein, O.Y. Mian, Nima Sharifi, Shinjini Ganguly, P. Wilkinson, Kevin L. Stephans, Jay P. Ciezki, Mona Patel, E. Davicioni
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 108:S41
Autor:
Aimalie Hardaway, O.Y. Mian, Eric A. Klein, Aysegul Balyimez, Monaben Patel, Rahul D. Tendulkar, Zaeem lone, Nima Sharifi, Elai Davicioni, Shinjini Ganguly
Publikováno v:
Cancer Research. 80:2082-2082
Purpose: Androgen deprivation therapy (ADT) is the linchpin therapeutic for locally advanced and metastatic PCa. However, resistance to ADT is common and has been associated with a gain of function mutation (A1245C) in the 3β-HSD enzyme, which catal
Autor:
Zaeem Lone, Shinjini Ganguly, Aimalie Hardaway, Omar Y. Mian, Nima Sharifi, Mona Patel, Kevin L. Stephans, Moshe Chaim Ornstein, Rahul D. Tendulkar, Aysegul Balyimez, Eric A. Klein, Jorge A. Garcia, Elai Davicioni, Jay P. Ciezki
Publikováno v:
Journal of Clinical Oncology. 38:349-349
349 Background: Resistance to ADT is associated with a gain of function mutation in the 3β-HSD enzyme, which catalyzes extragonadal/intratumoral DHT synthesis. As androgen signaling is known to upregulate the DNA damage response (DDR), we investigat