Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Aimée Zuniga"'
Autor:
Marta Losa, Iros Barozzi, Marco Osterwalder, Viviana Hermosilla-Aguayo, Angela Morabito, Brandon H. Chacón, Peyman Zarrineh, Ausra Girdziusaite, Jean Denis Benazet, Jianjian Zhu, Susan Mackem, Terence D. Capellini, Diane Dickel, Nicoletta Bobola, Aimée Zuniga, Axel Visel, Rolf Zeller, Licia Selleri
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract A lingering question in developmental biology has centered on how transcription factors with widespread distribution in vertebrate embryos can perform tissue-specific functions. Here, using the murine hindlimb as a model, we investigate the
Externí odkaz:
https://doaj.org/article/7c9a9b83afdc4ea8afaf6d100fd069b1
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102603- (2023)
Summary: Tissue autofluorescence poses significant challenges for RNA and protein analysis using fluorescence-based techniques. Here, we present a protocol that combines oxidation-mediated autofluorescence reduction with detergent-based tissue permea
Externí odkaz:
https://doaj.org/article/95195cdc884e4e449676aff05df96ce4
Autor:
Jonas Malkmus, Laurène Ramos Martins, Shalu Jhanwar, Bonnie Kircher, Victorio Palacio, Rushikesh Sheth, Francisca Leal, Amandine Duchesne, Javier Lopez-Rios, Kevin A. Peterson, Robert Reinhardt, Koh Onimaru, Martin J. Cohn, Aimée Zuniga, Rolf Zeller
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The BMP antagonist Gremlin1 balances BMP and SHH signalling, endowing limb bud development with robustness. Here, the authors identify enhancers controlling Grem1 levels in an additive, and spatial regulation in a synergistic manner, providing digit
Externí odkaz:
https://doaj.org/article/8daa3afd4ca340eaad289f8348f3805b
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The vertebrate limb bud is a paradigm to uncover the fundamental mechanisms that govern embryogenesis and evolutionary diversification. Here the authors compare mouse and chicken limb bud development to study the impact of genome evolution on conserv
Externí odkaz:
https://doaj.org/article/4f4c006c8e084f5fb6335b5b5fcf9b23
Autor:
Kelsey H Elliott, Xiaoting Chen, Joseph Salomone, Praneet Chaturvedi, Preston A Schultz, Sai K Balchand, Jeffrey D Servetas, Aimée Zuniga, Rolf Zeller, Brian Gebelein, Matthew T Weirauch, Kevin A Peterson, Samantha A Brugmann
Publikováno v:
eLife, Vol 9 (2020)
Despite a common understanding that Gli TFs are utilized to convey a Hh morphogen gradient, genetic analyses suggest craniofacial development does not completely fit this paradigm. Using the mouse model (Mus musculus), we demonstrated that rather tha
Externí odkaz:
https://doaj.org/article/659f921a3e85487a949e94d7fb166cc9
Autor:
Frédéric Laurent, Ausra Girdziusaite, Julie Gamart, Iros Barozzi, Marco Osterwalder, Jennifer A. Akiyama, Joy Lincoln, Javier Lopez-Rios, Axel Visel, Aimée Zuniga, Rolf Zeller
Publikováno v:
Cell Reports, Vol 19, Iss 8, Pp 1602-1613 (2017)
The HAND2 transcriptional regulator controls cardiac development, and we uncover additional essential functions in the endothelial to mesenchymal transition (EMT) underlying cardiac cushion development in the atrioventricular canal (AVC). In Hand2-de
Externí odkaz:
https://doaj.org/article/f88dd9f519ce4a2cbd3c44cff84ccf43
Autor:
Debora Schmitz-Rohmer, Simone Probst, Zhong-Zhou Yang, Frédéric Laurent, Michael B Stadler, Aimée Zuniga, Rolf Zeller, Debby Hynx, Brian A Hemmings, Alexander Hergovich
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136566 (2015)
Studies of mammalian tissue culture cells indicate that the conserved and distinct NDR isoforms, NDR1 and NDR2, play essential cell biological roles. However, mice lacking either Ndr1 or Ndr2 alone develop normally. Here, we studied the physiological
Externí odkaz:
https://doaj.org/article/654538069ff24c9aa7e82c33a337670c
Autor:
Catherine Vaillant, Paola Valdivieso, Sandro Nuciforo, Marcel Kool, Alexandra Schwarzentruber-Schauerte, Hélène Méreau, Erik Cabuy, Johannes A Lobrinus, Stefan Pfister, Aimée Zuniga, Stephan Frank, Rolf Zeller
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124870 (2015)
Medulloblastomas are malignant childhood brain tumors that arise due to the aberrant activity of developmental pathways during postnatal cerebellar development and in adult humans. Transcriptome analysis has identified four major medulloblastoma subg
Externí odkaz:
https://doaj.org/article/aaa65cdf455b4341a050f6760609afc8
Autor:
Marta Losa, Iros Barozzi, Marco Osterwalder, Peyman Zarrineh, Jean Denis Benazet, Brandon Chacon, Ausra Girdziusaite, Angela Morabito, Jianjian Zhu, Susan Mackem, Terence Capellini, Nicoletta Bobola, Diane Dickel, Aimée Zuniga, Axel Visel, Rolf Zeller, Licia Selleri
During development cell fates are specified by tightly controlled gene expression programs. PBX TALE transcription factors control gene regulatory networks (GRN) that direct vertebrate tissue patterning and organ morphogenesis. How PBX1/2 proteins ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb3b6289b67ce5c003d940fcaf337aa1
https://doi.org/10.1101/2022.03.08.483529
https://doi.org/10.1101/2022.03.08.483529
Autor:
Rolf Zeller, Julie Gamart, Robert Reinhardt, Thomas Oberholzer, Frédéric Laurent, Aimée Zuniga, Iros Barozzi, Laurène Ramos Martins, Axel Visel
Publikováno v:
Development (Cambridge, England), vol 148, iss 23
Development (Cambridge, England)
article-version (VoR) Version of Record
Development
Development (Cambridge, England)
article-version (VoR) Version of Record
Development
SMAD4 regulates gene expression in response to BMP and TGFβ signal transduction, and is required for diverse morphogenetic processes, but its target genes have remained largely elusive. Here, we identify the SMAD4 target genes in mouse limb buds usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d676506e583373e9d8e92abd208b1c5
https://escholarship.org/uc/item/47k5k30b
https://escholarship.org/uc/item/47k5k30b