Spermidinyl-CoA-based HAT inhibitors block DNA repair and provide cancer- specific chemo-and radiosensitization

Autor: Joseph Parello, Casimir Blonski, Ruth A. Gjerset, Jean-Louis Banères, Aimée Martin, Keya Bandyopadhyay

Publikováno v: Cell Cycle. 8:2779-2788

Acetyl group turnover on specific lysine epsilon-amino groups of the core chromosomal histones regulates DNA accessibility function, and the acetylating and deacetylating enzymes that govern the turnover provide important targets for the development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61264775f7b61872790f7b92b535cef
https://doi.org/10.4161/cc.8.17.9416

Molecular Characterization of a Purified 5-HT4 Receptor

Autor: Aimée Martin, Danielle Mesnier, Joël Bockaert, Aline Dumuis, Lara Joubert, Jean-Louis Banères

Publikováno v: Journal of Biological Chemistry. 280:20253-20260

Serotonin 5-HT4(a) receptor, a G-protein-coupled receptor (GPCR), was produced as a functional isolated protein using Escherichia coli as an expression system. The isolated receptor was characterized at the molecular level by circular dichroism (CD)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7adfd4938410ab0d098b872baec3d84
https://doi.org/10.1074/jbc.m412009200

A Minimized Human Integrin α5β1 That Retains Ligand Recognition

Autor: Aimée Martin, Joseph Parello, Jean-Louis Banères, Françoise Roquet

Publikováno v: Journal of Biological Chemistry. 275:5888-5903

Two isolated recombinant fragments from human integrin alpha(5)beta(1) encompassing the FG-GAP repeats III to VII of alpha(5) and the insertion-type domain from beta(1), respectively, are structurally well defined in solution, based on CD evidence. D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497a182b03e1939db87a0ed986fa6c8d
https://doi.org/10.1074/jbc.275.8.5888

Structure of a GPCR ligand in its receptor-bound state: leukotriene B4 adopts a highly constrained conformation when associated to human BLT2

Autor: Fabrice Giusti, Eric Guittet, Carine van Heijenoort, Marjorie Damian, Jean-Louis Banères, Aimée Martin, Laurent J. Catoire, Jean-Luc Popot

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2010, 132 (26), pp.9049-57. ⟨10.1021/ja101868c⟩
Journal of the American Chemical Society, American Chemical Society, 2010, 132 (26), pp.9049-9057. ⟨10.1021/ja101868c⟩

International audience; G protein-coupled receptors (GPCRs) are key players in signal recognition and cell communication and are among the most important targets for drug development. Direct structural information on the conformation of GPCR ligands

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40e78ff6347e415cb04680c5118dca3
https://hal.archives-ouvertes.fr/hal-00512070

Asymmetric conformational changes in a GPCR dimer controlled by G-proteins

Autor: Danielle Mesnier, Jean-Louis Banères, Marjorie Damian, Aimée Martin, Jean-Philippe Pin

Publikováno v: EMBO Journal
EMBO Journal, EMBO Press, 2006, 25 (24), pp.5693-5702. ⟨10.1038/sj.emboj.7601449⟩

G-protein-coupled receptors (GPCRs) are key players in cell communication. Although long considered as monomeric, it now appears that these heptahelical proteins can form homo- or heterodimers. Here, we analyzed the conformational changes in each sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc447f07c1c4767a1d2796270dc21340
https://europepmc.org/articles/PMC1698895/