Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ailsa L. McGregor"'
Autor:
Pritika Narayan, Suzanne Reid, Emma L. Scotter, Ailsa L. McGregor, Nasim F. Mehrabi, Malvindar K. Singh-Bains, Michelle Glass, Richard L.M. Faull, Russell G. Snell, Mike Dragunow
Publikováno v:
Neurobiology of Disease, Vol 146, Iss , Pp 105092- (2020)
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in exon 1 of the huntingtin gene. Emerging evidence shows that additional epigenetic factors can modify disease phenotypes. Harnessing the abilit
Externí odkaz:
https://doaj.org/article/46c0279f44bc402698babefffb127715
Publikováno v:
European Journal of Neuroscience. 55:1344-1355
Recent evidence suggests that treatment with antidepressants may promote functional recovery. However, the timeframe in which these pharmacological agents can influence stroke recovery is not well understood. This research investigated whether delaye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e8541e87fdf7dbee4772f141139cd7
https://doi.org/10.1111/ejn.15601
https://doi.org/10.1111/ejn.15601
Publikováno v:
Drugs - Real World Outcomes. 9:165-173
Patients who develop seizures after stroke have disproportionately poorer outcomes and increased mortality. Our objective was to investigate whether exposure to anti-epileptic medications influenced long-term functional status after stroke. We used l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::542073f7b53b9b27304298616004683c
https://doi.org/10.1007/s40801-021-00280-5
https://doi.org/10.1007/s40801-021-00280-5
Autor:
Carolyn J. Barrett, Ailsa L. McGregor, Pratik C. Thakkar, P. Alan Barber, Julian F. R. Paton, Fiona D McBryde
Publikováno v:
Hypertension. 75:740-747
Over 80% of patients exhibit an acute increase in blood pressure (BP) following stroke. Current clinical guidelines make no distinction in BP management between patients with or without prior hypertension. Spontaneously hypertensive (SH) rats were pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34d2f2a1bf6cd137470fe4ed8398a6c
https://doi.org/10.1161/hypertensionaha.119.14219
https://doi.org/10.1161/hypertensionaha.119.14219
Autor:
Julian F. R. Paton, Fiona D McBryde, Carolyn J. Barrett, Paul Alan Barber, Pratik C. Thakkar, Ailsa L. McGregor
Publikováno v:
Stroke. 50:2522-2530
Background and Purpose— Over 80% of ischemic stroke patients show an abrupt increase in arterial blood pressure in the hours and days following ischemic stroke. Whether this poststroke hypertension is beneficial or harmful remains controversial and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be9d15af2e6f87feceaa1e4caad1ac49
https://doi.org/10.1161/strokeaha.119.026459
https://doi.org/10.1161/strokeaha.119.026459
Publikováno v:
Endocrinology
Mice with a targeted mutation in the pro-opiomelanocortin (Pomc) gene (Pomctm1/tm1 mice) are unable to synthesize desacetyl-α-MSH and α-MSH and they develop obesity when fed chow diet. In this study, we hypothesized that a chronic high-fat (HF) die
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5c30881b2e8ebdeaec5da6427cfe3f
https://doi.org/10.1210/en.2018-00924
https://doi.org/10.1210/en.2018-00924
Publikováno v:
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 30(5)
Obesity is a risk factor for ischaemic stroke but provides a survival advantage. The relationship between body mass index (BMI) and long-term function is less clear. The presence of an obesity paradox can inform clinical care and identify vulnerable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd22b115863e131f3082f0676af31f1
https://pubmed.ncbi.nlm.nih.gov/33714074
https://pubmed.ncbi.nlm.nih.gov/33714074
Autor:
Michelle Glass, Ailsa L. McGregor, Suzanne J. Reid, Russell G. Snell, Mike Dragunow, Malvindar K. Singh-Bains, Pritika Narayan, Emma L. Scotter, Nasim F. Mehrabi, Richard L.M. Faull
Publikováno v:
Neurobiology of Disease, Vol 146, Iss, Pp 105092-(2020)
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in exon 1 of the huntingtin gene. Emerging evidence shows that additional epigenetic factors can modify disease phenotypes. Harnessing the abilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1cd463e151c45f35f1bccdfe9bc6495
https://pubmed.ncbi.nlm.nih.gov/32979507
https://pubmed.ncbi.nlm.nih.gov/32979507
Publikováno v:
Neuropharmacology. 116:233-246
Objective Studies in the post mortem human brain and in genetic mouse model suggest that dysfunctional cholinergic neurotransmission, through a loss of agonist rather than receptors may be a significant contributing factor to HD pathology. If correct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e469b5b9e3d566d2ed1dfd37eee72118
https://doi.org/10.1016/j.neuropharm.2016.12.021
https://doi.org/10.1016/j.neuropharm.2016.12.021
Autor:
Pratik C. Thakkar, Fiona D McBryde, Ailsa L. McGregor, Sarah-Jane Guild, Julian Judith Paton, Carolyn J. Barrett
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5ced3da4fca63121e6ea1e16021029a
https://doi.org/10.1096/fasebj.2019.33.1_supplement.832.7
https://doi.org/10.1096/fasebj.2019.33.1_supplement.832.7