Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ailsa J. Dalgliesh"'
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Despite bovine pericardium (BP) being the primary biomaterial used in heart valve bioprostheses, recipient graft-specific immune responses remain a significant cause of graft failure. Consequently, tissue antigenicity remains the principal b
Externí odkaz:
https://doaj.org/article/5fcaf593be4f4fc2abdf5ff8840be416
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0214656 (2019)
PLoS ONE
PLoS ONE
Glutaraldehyde-fixed bovine pericardium is currently the most popular biomaterial utilized in the creation of bioprosthetic heart valves. However, recent studies indicate that glutaraldehyde fixation results in calcification and structural valve dete
Autor:
Nicholas A Shortreed, Anjali J Panicker, Ailsa J Dalgliesh, Katherine V Gates, Leigh G Griffiths
Publikováno v:
The Journal of Immunology. 204:161.9-161.9
Valve replacement is an important therapeutic approach for management of valvular heart disease, accounting for over 200,000 surgeries annually worldwide. Deficiencies of current heart valve prostheses led the NHLBI cardiac surgery working group to h
Autor:
Manuela Lopera-Higuita, Jeny Shklover, Mojtaba Parvizi, Leigh G. Griffiths, Ailsa J. Dalgliesh
Antigenicity remains the primary barrier towards expanding the use of unfixed xenogeneic biomaterials in clinical applications. An unfixed xenogeneic biomaterial devoid of antigenicity, with maintained structural and mechanical integrity, has potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1b98dd4496ae8064a4e25f90341275
https://europepmc.org/articles/PMC6349227/
https://europepmc.org/articles/PMC6349227/
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports
Scientific Reports
Despite bovine pericardium (BP) being the primary biomaterial used in heart valve bioprostheses, recipient graft-specific immune responses remain a significant cause of graft failure. Consequently, tissue antigenicity remains the principal barrier fo
Publikováno v:
Tissue engineering. Part A. 23(13-14)
Current heart valve prostheses are associated with significant complications, including aggressive immune response, limited valve life expectancy, and inability to grow in juvenile patients. Animal derived “tissue” valves undergo glutaraldehyde f
Publikováno v:
Proteomics. Clinical applications, vol 10, iss 1
Extracellular matrix (ECM) has emerged as a dynamic tissue component, providing not only structural support, but also functionally participating in a wide range of signaling events during development, injury, and disease remodeling. Investigation of