Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ailisa Blum"'
Autor:
Merja Joensuu, Parnayan Syed, Saber H Saber, Vanessa Lanoue, Tristan P Wallis, James Rae, Ailisa Blum, Rachel S Gormal, Christopher Small, Shanley Sanders, Anmin Jiang, Stefan Mahrhold, Nadja Krez, Michael A Cousin, Ruby Cooper‐White, Justin J Cooper‐White, Brett M Collins, Robert G Parton, Giuseppe Balistreri, Andreas Rummel, Frédéric A Meunier
Publikováno v:
Joensuu, M, Syed, P, Saber, S H, Lanoue, V, Wallis, T P, Rae, J, Blum, A, Gormal, R S, Small, C, Sanders, S, Jiang, A, Mahrhold, S, Krez, N, Cousin, M A, Cooper-White, R, Cooper-White, J J, Collins, B M, Parton, R G, Balistreri, G, Rummel, A & Meunier, F A 2023, ' Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry ', EMBO Journal . https://doi.org/10.15252/embj.2022112095
The unique nerve terminal targeting of botulinum neurotoxin type A (BoNT/A) is due to its capacity to bind two receptors on the neuronal plasma membrane: polysialoganglioside (PSG) and synaptic vesicle glycoprotein 2 (SV2). Whether and how PSGs and S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bce58369df1764dd9ade86c6d436254
https://hdl.handle.net/20.500.11820/ba1259b2-1e41-40ca-b588-79326111cfdd
https://hdl.handle.net/20.500.11820/ba1259b2-1e41-40ca-b588-79326111cfdd
Autor:
Mehdi Moustaqil, Frederic A. Meunier, Alex Jade McCann, Frank Fontaine, Yann Gambin, Peter Koopman, Ailisa Blum, Winnie Luu, Jieqiong Lou, Hui Liu, Mathias Francois, Matthew S Graus, Paulina Rudolffi-Soto, Zhe Liu, Emma Sierecki, Elizabeth Hinde
Publikováno v:
Nucleic Acids Research
Few genetically dominant mutations involved in human disease have been fully explained at the molecular level. In cases where the mutant gene encodes a transcription factor, the dominant-negative mode of action of the mutant protein is particularly p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23264690e289c3a75afda1ee8736b435
http://europepmc.org/articles/PMC8565327
http://europepmc.org/articles/PMC8565327
Autor:
Merja Joensuu, Vanessa Lanoue, Parnayan Syed, Tristan P. Wallis, James Rae, Ailisa Blum, Rachel Gormal, Christopher Small, Shanley Sanders, Anmin Jiang, Stefan Mahrhold, Nadja Krez, Michael Cousin, Ruby Cooper-White, Justin J. Cooper-White, Brett M. Collins, Robert G. Parton, Giuseppe Balistreri, Andreas Rummel, Frédéric A. Meunier
The extreme neurotoxicity of botulinum neurotoxins (BoNTs), broadly used as a therapeutics, is mediated by their direct binding to two plasma membrane receptors: polysialogangliosides (PSGs) and serotype-dependently either synaptotagmin 1/2 (Syt1/2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b8a1b334c23e1f2878ae367fcf15319
https://doi.org/10.1101/2022.02.28.482398
https://doi.org/10.1101/2022.02.28.482398
Autor:
Michele Bastiani, Harriet P. Lo, Jan Steyaert, Rachel S. Gormal, Els Pardon, Merja Joensuu, Srikanth Budnar, Adekunle T. Bademosi, James Rae, Ailisa Blum, Jean Giacomotto, Pranesh Padmanabhan, Frederic A. Meunier, Geoffrey J. Goodhill, Alpha S. Yap, Tristan P. Wallis, Massimo A. Hilliard, Walter G. Thomas, Ravikiran Kasula, Robert G. Parton, Charles Ferguson, Sean Coakley
Publikováno v:
Proc Natl Acad Sci U S A
None of the current superresolution microscopy techniques can reliably image the changes in endogenous protein nanoclustering dynamics associated with specific conformations in live cells. Single-domain nanobodies have been invaluable tools to isolat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d015bc888a680e98a149ee7b2bbde934
https://doi.org/10.1073/pnas.2007443117
https://doi.org/10.1073/pnas.2007443117
Autor:
Elizabeth Hinde, Winnie Luu, Jieqiong Lou, Alex Jade McCann, Frederic A. Meunier, Hui Liu, Mathias Francois, Ailisa Blum, Peter Koopman, Emma Sierecki, Mehdi Moustaqil, Zhe Liu, Frank Fontaine, Yann Gambin
Few genetically dominant mutations involved in human disease have been fully explained at the molecular level. In cases where the mutant gene encodes a transcription factor, the dominant-negative mode of action of the mutant protein is particularly p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29c385eab7881711566225045980adbf
https://doi.org/10.1101/2020.11.11.378968
https://doi.org/10.1101/2020.11.11.378968
Autor:
Donald M. Gardiner, Mikkel Rank Nielsen, Jacqueline Batley, Lena Studt, Giovanni Beccari, Aurélie H. Benfield, Ailisa Blum, Jens Laurids Sørensen, Simone Bachleitner, Lorenzo Covarelli
Publikováno v:
Blum, A, H. Benfield, A, Sørensen, J L, Nielsen, M R, Bachleitner, S, Studt, L, Beccari, G, Covarelli, L, Batley, J & Gardiner, D M 2019, ' Regulation of a novel Fusarium cytokinin in Fusarium pseudograminearum ', Fungal Biology, vol. 123, no. 3, pp. 255-266 . https://doi.org/10.1016/j.funbio.2018.12.009
Fusarium pseudograminearum is an agronomically important fungus, which infects many crop plants, including wheat, where it causes Fusarium crown rot. Like many other fungi, the Fusarium genus produces a wide range of secondary metabolites of which on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de9324496946a1f3933eccf5a072958b
https://vbn.aau.dk/ws/files/313649360/Regulation_of_a_novel_Fusarium_cytokinin_in_Fusarium_pseudo_2019_Fungal_Biol.pdf
https://vbn.aau.dk/ws/files/313649360/Regulation_of_a_novel_Fusarium_cytokinin_in_Fusarium_pseudo_2019_Fungal_Biol.pdf
Autor:
Saroja Weeratunga, Mercè Salla-Martret, Ravikiran Kasula, Brett M. Collins, Tristan P. Wallis, Pranesh Padmanabhan, Merja Joensuu, Mahdie Mollazade, Ailisa Blum, Frederic A. Meunier, Emma Livingstone, Julie Z. Brouillet, Jiang Anmin, Rachel S. Gormal, Ramón Martínez-Mármol, Ye Jin Chai
Publikováno v:
SSRN Electronic Journal.
SNARE-mediated secretory vesicle (SV) exocytosis underpins neuronal communication. Munc18-1 orchestrates SNARE complex formation by controlling the opening of syntaxin-1A. How the SV-plasma membrane interface becomes fusion competent at nanoscale lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c541658d4fca4d5690bc9fb323a473e0
https://doi.org/10.2139/ssrn.3362260
https://doi.org/10.2139/ssrn.3362260
Autor:
Jacqueline Batley, Donald M. Gardiner, Kemal Kazan, Jiri Stiller, Ailisa Blum, Aurélie H. Benfield
Publikováno v:
Fungal Genetics and Biology. 90:1-11
Fusarium head blight and crown rot, caused by the fungal plant pathogen Fusarium graminearum, impose a major threat to global wheat production. During the infection, plants are contaminated with mycotoxins such as deoxynivalenol (DON), which can be t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4519864c29ba904f0c2918ac2a59ddb0
https://doi.org/10.1016/j.fgb.2016.02.005
https://doi.org/10.1016/j.fgb.2016.02.005
Publikováno v:
Fungal genetics and biology : FGB. 124
Trichothecene mycotoxin synthesis in the phytopathogen Fusarium graminearum involves primarily endoplasmic reticulum (ER)-localized enzymes of the mevalonate- and trichothecene biosynthetic pathways. Two exceptions are 3-hydroxy-3-methylglutaryl CoA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff91f2dbe808281547453faf1fe9c7d2
https://pubmed.ncbi.nlm.nih.gov/30579887
https://pubmed.ncbi.nlm.nih.gov/30579887
Autor:
Andreas Rummel, Nadja Krez, Christopher Small, Vanessa Lanoue, Merja Joensuu, Ailisa Blum, Frederic A. Meunier, Stefan Mahrhold, Mahdie Mollazade, Pranesh Padmanabhan
Publikováno v:
University of Queensland
Botulinum neurotoxin type-A (BoNT/A) is internalized into motor nerve terminals as part of its intoxication strategy to incapacitate nerve-muscle communication. The “dual receptor” model explained how BoNT/A initially interacts with GT1b ganglios
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f81da9c75d2e15a81cd24c9a9c45af5
https://doi.org/10.1016/j.toxicon.2018.11.122
https://doi.org/10.1016/j.toxicon.2018.11.122