Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse model.

Autor: Lauressergues E; Department of Cellular and Molecular Biology Pierre Fabre Research Centre 17, avenue Jean Moulin F-81106 Castres Cedex France., Heusler P; Department of Cellular and Molecular Biology Pierre Fabre Research Centre 17, avenue Jean Moulin F-81106 Castres Cedex France., Lestienne F; Department of Cellular and Molecular Biology Pierre Fabre Research Centre 17, avenue Jean Moulin F-81106 Castres Cedex France., Troulier D; Department of Developability Pierre Fabre Research Centre Castres France., Rauly-Lestienne I; Department of Cellular and Molecular Biology Pierre Fabre Research Centre 17, avenue Jean Moulin F-81106 Castres Cedex France., Tourette A; Department of Cellular and Molecular Biology Pierre Fabre Research Centre 17, avenue Jean Moulin F-81106 Castres Cedex France., Ailhaud MC; Department of Cellular and Molecular Biology Pierre Fabre Research Centre 17, avenue Jean Moulin F-81106 Castres Cedex France., Cathala C; Department of Cellular and Molecular Biology Pierre Fabre Research Centre 17, avenue Jean Moulin F-81106 Castres Cedex France., Tardif S; Department of Cellular and Molecular Biology Pierre Fabre Research Centre 17, avenue Jean Moulin F-81106 Castres Cedex France., Denais-Laliève D; Laboratory Animal Resources Pierre Fabre Research Centre Castres France., Calmettes MT; Laboratory Animal Resources Pierre Fabre Research Centre Castres France., Degryse AD; Laboratory Animal Resources Pierre Fabre Research Centre Castres France., Dumoulin A; Department of Developability Pierre Fabre Research Centre Castres France., De Vries L; Department of Cellular and Molecular Biology Pierre Fabre Research Centre 17, avenue Jean Moulin F-81106 Castres Cedex France., Cussac D; Department of Cellular and Molecular Biology Pierre Fabre Research Centre 17, avenue Jean Moulin F-81106 Castres Cedex France.

Publikováno v: Pharmacology research & perspectives [Pharmacol Res Perspect] 2016 Mar 04; Vol. 4 (2), pp. e00214. Date of Electronic Publication: 2016 Mar 04 (Print Publication: 2016).

Actions of the prototypical 5-HT1A receptor agonist 8-OH-DPAT at human alpha2-adrenoceptors: (+)8-OH-DPAT, but not (-)8-OH-DPAT is an alpha2B subtype preferential agonist.

Autor: Heusler P; Department of Cellular and Molecular Biology, Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, F-81106 Castres Cedex, France. peter.heusler@pierre-fabre.com, Rauly-Lestienne I, Tourette A, Tardif S, Ailhaud MC, Croville G, Cussac D

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2010 Aug 25; Vol. 640 (1-3), pp. 8-14. Date of Electronic Publication: 2010 May 07.

Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells.

Autor: Cussac D; Department of Cellular and Molecular Biology, Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, F 81106 Castres Cedex, France. didier.cussac@pierre-fabre.com, Boutet-Robinet E, Ailhaud MC, Newman-Tancredi A, Martel JC, Danty N, Rauly-Lestienne I

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2008 Oct 10; Vol. 594 (1-3), pp. 32-8. Date of Electronic Publication: 2008 Jul 30.