Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Aileen Shieh"'
Publikováno v:
Organic & Biomolecular Chemistry. 20:5254-5258
Nano-formulated, combinatory therapeutics that control the spatiotemporal aspects of drug release have potential to overcome many of the challenges faced in cancer therapy. Herein, we describe a peptide nanotube functionalized with two anticancer dru
Publikováno v:
Chemical communications (Cambridge, England). 56(71)
The self-assembly and covalent crosslinking of a camptothecin (CPT) tetrapeptide nanotube is reported. Intermolecular disulfide bond formation of a self-assembled CPT-peptide reversibly stabilized the nanotubes toward dissociation at low concentratio
Publikováno v:
Chemical Communications. 53:12806-12809
This work demonstrates that sonication, followed by polymer-wrapping, is an effective strategy to modulate the length of self-assembled nanotubes. The length distributions of the nanotubes were controlled by varying the amplitude of sonication. Wrapp
Autor:
Hui-Lung Sun, Samantha King, Yuan Sun, Carlo M. Croce, Anne Kim, Aileen Shieh, Se Hye Kim, Jon R. Parquette
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2834-2838
A simple, low molecular weight camptothecin-lysine conjugate is reported to self-assemble into nanotubes with diameters of 70-100nm and a drug loading level of 60.5%. The nanotubes exhibited promising in vitro cytotoxicity against cancer cell lines A
Autor:
Mark W. Grinstaff, Jonah A. Kaplan, Jon R. Parquette, Carlo M. Croce, Yuan Sun, Hui-Lung Sun, Aileen Shieh
Publikováno v:
Chemical Communications. 52:5254-5257
The self-assembly of 5-fluorouracil dilysine conjugates into self-supporting hydrogels, comprised of entangled nanofibers or rigid nanotubes with diameters of 10 and 16 nm, respectively, is reported. The rate of release of 5-Fu from the conjugates wa
Autor:
Carlo M. Croce, Hui-Lung Sun, Aileen Shieh, Yuan Sun, Mark W. Grinstaff, Jon R. Parquette, Se Hye Kim, Jonah A. Kaplan
Publikováno v:
Chemistry - A European Journal. 21:101-105
S)-Camptothecin (CPT)-conjugated dipep- tides are reported that preassemble into nanotubes with diameters ranging from 80-120 nm. These nanoassemblies maintain a high (~ 47 %) drug loading and exhibit greater drug stability (i.e., resistance to lacto