Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Aileen A. Ren"'
Autor:
Derek C. Sung, Mei Chen, Martin H. Dominguez, Aparna Mahadevan, Xiaowen Chen, Jisheng Yang, Siqi Gao, Aileen A. Ren, Alan T. Tang, Patricia Mericko, Raiyah Patton, Michelle Lee, Melanie Jannaway, Astrid F. Nottebaum, Dietmar Vestweber, Joshua P. Scallan, Mark L. Kahn
Publikováno v:
Nat Cardiovasc Res
Sinusoids are specialized, low pressure blood vessels in the liver, bone marrow, and spleen required for definitive hematopoiesis. Unlike other blood endothelial cells (ECs), sinusoidal ECs express high levels of VEGFR3. VEGFR3 and its ligand VEGF-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35723b9b5f0917bb4c4481a95b69a8f6
https://europepmc.org/articles/PMC9997205/
https://europepmc.org/articles/PMC9997205/
Autor:
Issam A. Awad, Abhinav Srinath, Miguel Angel Lopez-Ramirez, Mark H. Ginsberg, Mark L. Kahn, Douglas A. Marchuk, Aileen A. Ren, Daniel A. Snellings, Romuald Girard, Courtney C. Hong
Publikováno v:
Circulation Research. 129:195-215
Cerebral cavernous malformations are acquired vascular anomalies that constitute a common cause of central nervous system hemorrhage and stroke. The past 2 decades have seen a remarkable increase in our understanding of the pathogenesis of this vascu
Autor:
Douglas A. Marchuk, Daniel A. Snellings, Rhonda Lightle, Issam A. Awad, Aileen A. Ren, Ying Li, Abhinav Srinath, Chang Chen, Romuald Girard, Mark L. Kahn, Sharbel Romanos
Cerebral cavernous malformations (CCM) are a neurovascular anomaly that may occur sporadically in otherwise healthy individuals, or be inherited by autosomal dominant mutations in the genes that encode the proteins of the CCM signaling complex (KRIT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3dd13abff056810bc0c3be87724d46e
https://doi.org/10.1101/2021.08.25.457657
https://doi.org/10.1101/2021.08.25.457657
Autor:
Thomas R. Moore, Nicholas Hobson, Rhonda Lightle, Mark L. Kahn, Romuald Girard, Michael T. Lawton, Marco Castro, Courtney C. Hong, Jakob Körbelin, Derek C. Sung, M. Makenzie Beaman, Mei Chen, Issam A. Awad, Yourong S. Su, Alan T. Tang, Robert Shenkar, Markus Schwaninger, Douglas A. Marchuk, Daniel A. Snellings, Matthew R Detter, Sharbel Romanos, Christian R Benavides, Michael Potente, Jisheng Yang, Aileen A. Ren, J. Michael Ruppert, Patricia Mericko, Helge Müller-Fielitz
Publikováno v:
Nature
Vascular malformations are thought to be monogenic disorders that result in dysregulated growth of blood vessels. In the brain, cerebral cavernous malformations (CCMs) arise owing to inactivation of the endothelial CCM protein complex, which is requi
Autor:
Romuald Girard, Issam A. Awad, Thomas R. Moore, Xi Yang, Lukas E. Dow, Jaesung P. Choi, Nicholas Hobson, Carl F Wittig, Robert Shenkar, Mark L. Kahn, Courtney C. Hong, Rhonda Lightle, Patricia Mericko-Ishizuka, N. Adrian Leu, Markus Schwaninger, Jisheng Yang, Andrea A. Guerrero, Hideto Watanabe, Rui Wang, Li Li, Stephanie Sterling, Wang Min, Xiangjian Zheng, Sean P. Polster, Douglas A. Marchuk, Lauren M. Goddard, Matthew R Detter, Mei Chen, Alan T. Tang, Aileen A. Ren
Publikováno v:
The Journal of Experimental Medicine
In this commentary on Hong et al., Bill Muller explains the significance of their findings as a mechanism for the non–cell autonomous pathogenesis of CCMs and the potential relevance of targeting ADAMTS5 therapeutically in this condition, for which
Autor:
Tang AT; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA., Sullivan KR; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA., Hong CC; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA., Goddard LM; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA., Mahadevan A; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA., Ren A; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA., Pardo H; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA., Peiper A; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA., Griffin E; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA., Tanes C; Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Mattei LM; Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Yang J; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA., Li L; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA., Mericko-Ishizuka P; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA., Shen L; Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA., Hobson N; Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA., Girard R; Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA., Lightle R; Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA., Moore T; Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA., Shenkar R; Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA., Polster SP; Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA., Rödel CJ; Institute for Biochemistry and Biology, Department of Animal Physiology, Potsdam University, Karl-Liebknecht-Str. 24-25, Haus 26, 14476 Potsdam, Germany., Li N; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Zhu Q; Graduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Whitehead KJ; Division of Cardiovascular Medicine and the Program in Molecular Medicine, University of Utah, Salt Lake City, UT 84112, USA., Zheng X; Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.; Centenary Institute, Sydney Medical School, University of Sydney, Sydney, NSW 2050, Australia., Akers A; Angioma Alliance, Norfolk, VA 23517, USA., Morrison L; Department of Neurology and Pediatrics, University of New Mexico, Albuquerque, NM 87106, USA., Kim H; Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA., Bittinger K; Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Lengner CJ; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Schwaninger M; Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, 23562 Lübeck, Germany., Velcich A; Department of Cell Biology, Albert Einstein College of Medicine/Albert Einstein Cancer Center, NY 10461, USA., Augenlicht L; Department of Cell Biology, Albert Einstein College of Medicine/Albert Einstein Cancer Center, NY 10461, USA., Abdelilah-Seyfried S; Institute for Biochemistry and Biology, Department of Animal Physiology, Potsdam University, Karl-Liebknecht-Str. 24-25, Haus 26, 14476 Potsdam, Germany.; Institute of Molecular Biology, Hannover Medical School, Carl-Neuberg Str. 1, D-30625 Hannover, Germany., Min W; Department of Pathology and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06510, USA., Marchuk DA; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA., Awad IA; Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA., Kahn ML; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA. markkahn@pennmedicine.upenn.edu.
Publikováno v:
Science translational medicine [Sci Transl Med] 2019 Nov 27; Vol. 11 (520).
Autor:
Jinn S; Diabetic Cardiovascular Disease Center and Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA., Brandis KA; Diabetic Cardiovascular Disease Center and Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA., Ren A; Diabetic Cardiovascular Disease Center and Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA., Chacko A; Diabetic Cardiovascular Disease Center and Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA., Dudley-Rucker N; Diabetic Cardiovascular Disease Center and Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA., Gale SE; Diabetic Cardiovascular Disease Center and Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA., Sidhu R; Diabetic Cardiovascular Disease Center and Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA., Fujiwara H; Diabetic Cardiovascular Disease Center and Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA., Jiang H; Diabetic Cardiovascular Disease Center and Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA., Olsen BN; Diabetic Cardiovascular Disease Center and Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA., Schaffer JE; Diabetic Cardiovascular Disease Center and Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA., Ory DS; Diabetic Cardiovascular Disease Center and Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA. Electronic address: dory@wustl.edu.
Publikováno v:
Cell metabolism [Cell Metab] 2015 Jun 02; Vol. 21 (6), pp. 855-67. Date of Electronic Publication: 2015 May 14.
Autor:
Brandis KA; From the Diabetic Cardiovascular Disease Center, Washington University School of Medicine, St. Louis, Missouri 63110., Gale S, Jinn S, Langmade SJ, Dudley-Rucker N, Jiang H, Sidhu R, Ren A, Goldberg A, Schaffer JE, Ory DS
Publikováno v:
The Journal of biological chemistry [J Biol Chem] 2013 Dec 13; Vol. 288 (50), pp. 35703-13. Date of Electronic Publication: 2013 Oct 30.