Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Aileen, Houston"'
Autor:
Jonathan M. Keane, Philana Fernandes, Florian Kratz, Grace O'Callaghan, Cormac G. M. Gahan, Susan A. Joyce, Catherine Stanton, Niall P. Hyland, Aileen Houston
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 4, Pp n/a-n/a (2024)
Abstract Although classically recognized as a neurotransmitter, gamma aminobutyric acid (GABA) has also been identified in colonic tumors. Moreover, the gut microbiome represents another potential source of GABA. Both GABAA and GABAB receptors have b
Externí odkaz:
https://doaj.org/article/b0d23d6d3f01418fa17e21750bd230e5
Publikováno v:
British Journal of Cancer. 128:735-747
The interleukin (IL)-36 cytokines are a sub-family of the IL-1 family which are becoming increasingly implicated in the pathogenesis of inflammatory diseases and malignancies. Initial studies of IL-36 signalling in tumorigenesis identified an immune-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40260cc440a2d0b5b9dd611e44376a5
https://doi.org/10.1038/s41416-022-02083-z
https://doi.org/10.1038/s41416-022-02083-z
Autor:
Peter Flood, Aine Fanning, Jerzy A. Woznicki, Tadhg Crowley, Andrea Christopher, Alessandra Vaccaro, Aileen Houston, Sheila McSweeney, Sarah Ross, Aileen Hogan, Elizabeth Brint, Agnieszka Skowyra, Milan Bustamante, Monica Ambrose, Gerard Moloney, John MacSharry, Marie-Louise Hammarström, Margot Hurley, Christine Fitzgibbons, Eamonn M. M. Quigley, Fergus Shanahan, Syed A. Zulquernain, Jane McCarthy, G. Steven Dodson, Karim Dabbagh, Bradford L. McRae, Silvia Melgar, Ken Nally
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 323:G439-G460
DNA sensor pathways can initiate inflammasome, cell death and type I interferon (IFN) signalling in immune-mediated inflammatory diseases (IMIDs); including type I interferonopathies. We investigated the involvement of these pathways in the pathogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad36e069e3c786f0cad7442974473f86
https://doi.org/10.1152/ajpgi.00104.2022
https://doi.org/10.1152/ajpgi.00104.2022
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti-inflammatory activity (IL-37, IL-38). These cytokines are k
Externí odkaz:
https://doaj.org/article/017675ee80964f2e9a7cb717beeaa004
Autor:
Caitlin O’Mahony, Adam Clooney, Siobhan F. Clarke, Mònica Aguilera, Aisling Gavin, Donjete Simnica, Mary Ahern, Aine Fanning, Maurice Stanley, Raul Cabrera Rubio, Elaine Patterson, Tatiana Marques, Rebecca Wall, Aileen Houston, Amr Mahmoud, Michael W. Bennett, Catherine Stanton, Marcus J. Claesson, Paul D. Cotter, Fergus Shanahan, Susan A. Joyce, Silvia Melgar
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 3; Pages: 1864
Environmental factors, including westernised diets and alterations to the gut microbiota, are considered risk factors for inflammatory bowel diseases (IBD). The mechanisms underpinning diet-microbiota-host interactions are poorly understood in IBD. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96bf85b230443a2eb28e579281b55cbb
Publikováno v:
Cellular and Molecular Life Sciences
The IL-36 family of cytokines were first identified in 2000 based on their sequence homology to IL-1 cytokines. Over subsequent years, the ability of these cytokines to either agonise or antagonise an IL-1R homologue, now known as the IL-36 Receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1bd02ba2c23555485c86722255d662
https://doi.org/10.1007/s00018-021-03909-4
https://doi.org/10.1007/s00018-021-03909-4
Autor:
Kevin James Baker, Emily Buskiewicz, Méabh Finucane, Adeleine Chelliah, Louise Burke, Aileen Houston, Elizabeth Brint
Publikováno v:
Cytokine. 165:156170
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee8407595d5b95ecec9863eddbf7ae6c
https://doi.org/10.1016/j.cyto.2023.156170
https://doi.org/10.1016/j.cyto.2023.156170
Publikováno v:
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 48(9)
Electrochemotherapy (ECT), the application of an electric impulse to deliver chemotherapy drugs into cells, has been in clinical trials since the early 1990s and has been used for a variety of different malignancies including melanoma and sarcoma. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844e212e8192e9ff91bc0b4714a0b4de
https://pubmed.ncbi.nlm.nih.gov/35667946
https://pubmed.ncbi.nlm.nih.gov/35667946
Autor:
Kevin Baker, Charlotte O’Donnell, Maura Bendix, Samuel Keogh, James Byrne, Michael O’Riordain, Peter Neary, Aileen Houston, Elizabeth Brint
Publikováno v:
Oncogene. 41(19)
The IL-36 cytokines are a recently described subset of the IL-1 family of cytokines, shown to play a role in the pathogenesis of intestinal diseases such as Inflammatory Bowel Disease (IBD). Given the link between IBD and colitis –associated cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471541d9f8120aa673d12d1bc31d1ba7
https://pubmed.ncbi.nlm.nih.gov/35365751
https://pubmed.ncbi.nlm.nih.gov/35365751
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123635 (2015)
Viral double-stranded RNA (dsRNA) is recognised by pathogen recognition receptors such as Toll-Like Receptor 3 (TLR3) and retinoic acid inducible gene-I (RIG-I), and results in cytokine and interferon production. Fas, a well characterised death recep
Externí odkaz:
https://doaj.org/article/b1c3d45d6cee46b699dbc0bda760243e