Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ailed M. Cruz"'
Autor:
Luis E. Velázquez-Vega, Michael Rivera-Robles, Annelis O. Sánchez-Álvarez, Pablo E. Vivas-Mejía, Miciely Aponte-Reyes, Ailed M. Cruz-Collazo, Nilmary Grafals-Ruiz, Stephanie Dorta-Estremera, Eliud Hernández-O'Farrill, Cornelis P Vlaar, Suranganie Dharmawardhane
Publikováno v:
Translational Oncology, Vol 44, Iss , Pp 101928- (2024)
Trastuzumab and trastuzumab-based treatments are the standard of care for breast cancer patients who overexpress the human epidermal growth factor receptor 2 (HER2). However, patients often develop resistance to trastuzumab via signaling from alterna
Externí odkaz:
https://doaj.org/article/08593e49e06c4c999cc8684c83fb0cd2
Autor:
Javier Reig-López, María del Mar Maldonado, Matilde Merino-Sanjuan, Ailed M. Cruz-Collazo, Jean F. Ruiz-Calderón, Victor Mangas-Sanjuán, Suranganie Dharmawardhane, Jorge Duconge
Publikováno v:
Pharmaceutics, Vol 12, Iss 10, p 975 (2020)
MBQ-167 is a dual inhibitor of the Rho GTPases Rac and Cdc42 that has shown promising results as an anti-cancer therapeutic at the preclinical stage. This drug has been tested in vitro and in vivo in metastatic breast cancer mouse models. The aim of
Externí odkaz:
https://doaj.org/article/5a76ba2dc99e411cbf4933a69f59f030
Autor:
Belmari Mendez, Jeyshka Reyes, Isabel Conde, Zulma Ramos, Eunice Lozada, Ailed M. Cruz, Gabriela Asencio, Augusto Carvajal, Suranganie Dharmawardhane, Dalice M. Piñero-Cruz, Eliud Hernández, Pablo Vivas, Claudia A. Ospina
Publikováno v:
Plants, Vol 9, Iss 1, p 93 (2020)
Species of the genus Simarouba have been studied because of their antimalarial and antileukemic activities. A group of oxygenated terpenes called quassinoids have been isolated from species of the Simarouba genus, and are responsible for its therapeu
Externí odkaz:
https://doaj.org/article/d8185411feef47b6967439bf407af9ee
Autor:
Nilmary Grafals-Ruiz, Ailed M. Cruz-Collazo, Anamaris Torres-Sánchez, Surangani Dharmawardhane
Publikováno v:
Cancer Research. 83:P2-01
Triple-negative breast cancer (TNBC) is an aggressive and recurrent type of breast cancer that accounts for over 15% of new diagnoses yearly. Patients with TNBC have limited response to hormonal or targeted therapies due to the lack of ER, PR, and HE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9f5c90f42eda9754ff2e924ca29435b
https://doi.org/10.1158/1538-7445.sabcs22-p2-01-05
https://doi.org/10.1158/1538-7445.sabcs22-p2-01-05
Autor:
Ailed M. Cruz-Collazo, Olga Katsara, Elizabeth Salvo, Jean Ruiz, Robert Schneider, Suranganie Dharmawardhane
Publikováno v:
Cancer Research. 82:4065-4065
Triple negative breast cancer (TNBC) represents a challenge because of its aggressiveness and resistance to standard chemotherapy. Since TNBC lacks targeted therapy options, the frontline therapy is Paclitaxel, which targets actively dividing cells i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e8236f23a417e4124bad53678d3d8ca
https://doi.org/10.1158/1538-7445.am2022-4065
https://doi.org/10.1158/1538-7445.am2022-4065
Autor:
Loyda M. Meléndez, Erick Suárez, Inmaculada Jorge, Frances Zenón, Jesús Vázquez, Horacio Serrano, Ailed M. Cruz, Annabell C. Segarra
Publikováno v:
PROTEOMICS - Clinical Applications. 10:144-155
PURPOSE Drug abuse is a major risk factor in the development and progression of HIV-1. This study defines the alterations in the plasma proteome of HIV-1-infected women that use cocaine. EXPERIMENTAL DESIGN Plasma samples from 12 HIV-seropositive His
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91bff4f172812070e2b7a15f2a10c01d
https://doi.org/10.1002/prca.201400204
https://doi.org/10.1002/prca.201400204
Autor:
Jean F. Ruiz-Calderon, Jorge Duconge, Suranganie Dharmawardhane, Ailed M. Cruz-Collazo, Maria Del Mar Maldonado, Gabriela Tatiana Rosado-González, Luis D. Borrero-Garcia
Publikováno v:
Cancer Research. 80:3020-3020
The Rho GTPases Rac and Cdc42 are potential targets against metastatic disease. Our group characterized the small molecule MBQ-167 as an effective dual Rac/Cdc42 inhibitor that reduces HER2 positive and triple negative tumor growth and metastasis in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c750a6230b6257c5483885fa714e664
https://doi.org/10.1158/1538-7445.am2020-3020
https://doi.org/10.1158/1538-7445.am2020-3020