Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Ailan Guo"'
Autor:
Xiaofeng Xin, David Gfeller, Jackie Cheng, Raffi Tonikian, Lin Sun, Ailan Guo, Lianet Lopez, Alevtina Pavlenco, Adenrele Akintobi, Yingnan Zhang, Jean‐François Rual, Bridget Currell, Somasekar Seshagiri, Tong Hao, Xinping Yang, Yun A Shen, Kourosh Salehi‐Ashtiani, Jingjing Li, Aaron T Cheng, Dryden Bouamalay, Adrien Lugari, David E Hill, Mark L Grimes, David G Drubin, Barth D Grant, Marc Vidal, Charles Boone, Sachdev S Sidhu, Gary D Bader
Publikováno v:
Molecular Systems Biology, Vol 9, Iss 1, Pp 1-17 (2013)
Abstract Src homology 3 (SH3) domains bind peptides to mediate protein–protein interactions that assemble and regulate dynamic biological processes. We surveyed the repertoire of SH3 binding specificity using peptide phage display in a metazoan, th
Externí odkaz:
https://doaj.org/article/fcff853d9bf24f249607d4cc31797396
Autor:
Li Zhang, Ngoc-Tung Tran, Hairui Su, Rui Wang, Yuheng Lu, Haiping Tang, Sayura Aoyagi, Ailan Guo, Alireza Khodadadi-Jamayran, Dewang Zhou, Kun Qian, Todd Hricik, Jocelyn Côté, Xiaosi Han, Wenping Zhou, Suparna Laha, Omar Abdel-Wahab, Ross L Levine, Glen Raffel, Yanyan Liu, Dongquan Chen, Haitao Li, Tim Townes, Hengbin Wang, Haiteng Deng, Y George Zheng, Christina Leslie, Minkui Luo, Xinyang Zhao
Publikováno v:
eLife, Vol 4 (2015)
RBM15, an RNA binding protein, determines cell-fate specification of many tissues including blood. We demonstrate that RBM15 is methylated by protein arginine methyltransferase 1 (PRMT1) at residue R578, leading to its degradation via ubiquitylation
Externí odkaz:
https://doaj.org/article/5c58a02b0b8046cdaa1d8e719d026b86
Autor:
Juan Palacios-Moreno, Lauren Foltz, Ailan Guo, Matthew P Stokes, Emily D Kuehn, Lynn George, Michael Comb, Mark L Grimes
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 4, p e1004130 (2015)
Protein phosphorylation plays a central role in creating a highly dynamic network of interacting proteins that reads and responds to signals from growth factors in the cellular microenvironment. Cells of the neural crest employ multiple signaling mec
Externí odkaz:
https://doaj.org/article/3e5ac0e88d7a4009af1282564789d5bc
Autor:
Priyanka Gupta, Keehn Strange, Rahul Telange, Ailan Guo, Heather Hatch, Amin Sobh, Jonathan Elie, Angela M. Carter, John Totenhagen, Chunfeng Tan, Yogesh A. Sonawane, Jiri Neuzil, Amarnath Natarajan, Ashley J. Ovens, Jonathan S. Oakhill, Thorsten Wiederhold, Karel Pacak, Hans K. Ghayee, Laurent Meijer, Sushanth Reddy, James A. Bibb
Publikováno v:
Cell Rep
SUMMARYMetabolic dysfunction mutations can impair energy sensing and cause cancer. Loss of function of mitochondrial TCA cycle enzyme, succinate dehydrogenase B (SDHB) results in various forms of cancer typified by pheochromocytoma (PC). Here we deli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd56e70ddf59494d8509fea21a0a5641
https://doi.org/10.2139/ssrn.4018612
https://doi.org/10.2139/ssrn.4018612
Autor:
Rohinton Tarapore, Varun V. Prabhu, Leah Lake, Martin Stogniew, Joshua E. Allen, Gina Theerman, Sara Morrow, Ailan Guo
Publikováno v:
Neuro Oncol
Imipridone ONC201 is an investigational agent in phase II clinical trials for H3 K27M-mutant diffuse midline glioma with evidence of durable objective responses and clinical symptom improvements as a single agent. The systemic pharmacokinetics of ONC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4492cdd399796c03a723a810e44c0ab8
https://europepmc.org/articles/PMC7651267/
https://europepmc.org/articles/PMC7651267/
Autor:
Leah Lake, Magdalena Nej, Yunlan Fang, Ailan Guo, Gina Theerman, Martin Stogniew, Rohinton Tarapore, Joshua E. Allen, Sara Morrow, Varun V. Prabhu
Publikováno v:
Cancer Research. 81:1370-1370
Imipridone ONC201 is a first-in-class DRD2 antagonist and ClpP agonist that is well tolerated and induces durable tumor regressions in H3 K27M-mutant glioma patients with once weekly dosing. We evaluated the toxicology, absorption, distribution, meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3da57a795f3c18ec2d4418e9e9c3de3
https://doi.org/10.1158/1538-7445.am2021-1370
https://doi.org/10.1158/1538-7445.am2021-1370
Autor:
Joao A. Paulo, Sean A. Beausoleil, Daniel Mulhern, Steven P. Gygi, Ailan Guo, Anthony Possemato
Publikováno v:
Journal of Proteome Research. 16:1506-1514
A comprehensive view of protein phosphorylation remains an unmet challenge in the field of cell biology. Mass spectrometry-based proteomics is one of the most promising approaches for identifying thousands of phosphorylation events in a single experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12554f89af4b740f8ab81d69a6079e28
https://doi.org/10.1021/acs.jproteome.6b00905
https://doi.org/10.1021/acs.jproteome.6b00905
Autor:
Eugene A. Woltering, Karel Pacak, Ennio Tasciotti, Herbert Chen, Hans K. Ghayee, Sarah C. Oltmann, Roberto Molinaro, Thorsten Wiederhold, Ailan Guo, James A. Bibb, Frank Gillardon, Nilesh Kumar, Angela M. Carter, Karine Pozo, Shanrong Zhang, Bruce G. Robinson, Anthony J. Gill, Sushanth Reddy, Chunfeng Tan, James A. Mobley, Kimmo J. Hatanpaa, Enrica De Rosa, Masaya Takahashi, Renata Jaskula-Sztul, Rahul Telange, Fiemu E. Nwariaku, Jonathan O. Martinez, M. Shahid Mukhtar, Elizabeth G. Grubbs
Publikováno v:
Proc Natl Acad Sci U S A
Disparities in cancer patient responses have prompted widespread searches to identify differences in sensitive vs. non-sensitive populations and form the basis of personalized medicine. This customized approach is dependent upon the development of pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8fd10afd9752dc7bdd1fc1ec6a1c7c
https://doi.org/10.1101/675637
https://doi.org/10.1101/675637
Autor:
Sara Morrow, Rohinton Tarapore, Varun V. Prabhu, Yunlan Fang, Magdalena Nej, Martin Stogniew, Joshua E. Allen, Ailan Guo
Publikováno v:
Neuro Oncol
Imipridone ONC201 is an investigational agent in phase II clinical trials for high grade gliomas as a single agent once weekly. Systemic and tumor exposure to ONC201 exceeds therapeutic thresholds consistently; however, exposure is variable despite f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ac3731ebc6ce373f5647e5c0ff06aa
https://doi.org/10.1093/neuonc/noaa215.424
https://doi.org/10.1093/neuonc/noaa215.424
Autor:
Cheryl H. Arrowsmith, Kimberly Lee, Tewfik Hamidi, Nicolas Veland, Christopher J Fry, Vidyasiri Vemulapalli, Ailan Guo, Jianqiang Bao, Anup Kumar Singh, Taiping Chen, Vicky Yang, Jianji Chen, Mark T. Bedford, Swanand Hardikar
Publikováno v:
The Journal of biological chemistry. 293(33)
Set7/9 (also known as Set7, Set9, Setd7, and Kmt7) is a lysine methyltransferase that catalyzes the methylation of multiple substrates, including histone H3 and non-histone proteins. Although not essential for normal development and physiology, Set7/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2c973f6a00ceff214848e58bf2d295
https://pubmed.ncbi.nlm.nih.gov/29959229
https://pubmed.ncbi.nlm.nih.gov/29959229