Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Aikseng Ooi"'
Autor:
Aryatara Shakya, Pengfei Liu, Jack Godek, Nicholas W. McKee, Matthew Dodson, Annadurai Anandhan, Aikseng Ooi, Joe G.N. Garcia, Max Costa, Eli Chapman, Donna D. Zhang
Publikováno v:
Redox Biology, Vol 65, Iss , Pp 102839- (2023)
p97 is a ubiquitin-targeted ATP-dependent segregase that regulates proteostasis, in addition to a variety of other cellular functions. Previously, we demonstrated that p97 negatively regulates NRF2 by extracting ubiquitylated NRF2 from the KEAP1-CUL3
Externí odkaz:
https://doaj.org/article/867adb2a581b43de91087339be330784
Autor:
Trace M. Jones, Claudia M. Espitia, Aikseng Ooi, Julie E. Bauman, Jennifer S. Carew, Steffan T. Nawrocki
Publikováno v:
Cell Death and Disease, Vol 13, Iss 4, Pp 1-13 (2022)
Abstract Patients with late-stage and human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) continue to have a very poor prognosis. The development of more effective novel therapies that improve overall survival and overco
Externí odkaz:
https://doaj.org/article/88a43a493faf4d40a38e304836fb332b
Autor:
Matthew Dodson, Wujing Dai, Annadurai Anandhan, Cody J. Schmidlin, Pengfei Liu, Nathan C. Wilson, Yongyi Wei, Naoya Kitamura, James J. Galligan, Aikseng Ooi, Eli Chapman, Donna D. Zhang
Publikováno v:
Molecular Oncology, Vol 16, Iss 8, Pp 1714-1727 (2022)
The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is often highly expressed in non‐small cell lung cancer (NSCLC). Through its target genes, NRF2 enhances cancer progression and chemo/radioresistance, leading to a poorer
Externí odkaz:
https://doaj.org/article/94f4ee304dad4931bce3ef765c659f45
Autor:
Pengfei Liu, Annadurai Anandhan, Jinjing Chen, Aryatara Shakya, Matthew Dodson, Aikseng Ooi, Eli Chapman, Eileen White, Joe GN. Garcia, Donna D. Zhang
Publikováno v:
Redox Biology, Vol 59, Iss , Pp 102570- (2023)
Background and aims: Caloric excess and sedentary lifestyles have led to an epidemic of obesity, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD). The objective of this study was to investigate the mechanisms underlying high fat diet
Externí odkaz:
https://doaj.org/article/a325bd8ab2114b2493bc1dc0404d0d03
Autor:
Adam N. Goldfarb, Katie C. Freeman, Ranjit K. Sahu, Kamaleldin E. Elagib, Maja Holy, Abhinav Arneja, Renata Polanowska-Grabowska, Alejandro A. Gru, Zollie White, Shadi Khalil, Michael J. Kerins, Aikseng Ooi, Norbert Leitinger, Chance John Luckey, Lorrie L. Delehanty
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Debilitating anemias in chronic diseases can result from deficient iron delivery to red cell precursors. Here, the authors show how this deficiency damages the cytoskeletal framework of progenitor cells and identify a targeted strategy for cytoskelet
Externí odkaz:
https://doaj.org/article/800cc6d5dbd045848f159db5971f182f
Autor:
Pengfei Liu, Matthew Dodson, Hui Li, Cody J. Schmidlin, Aryatara Shakya, Yongyi Wei, Joe G.N. Garcia, Eli Chapman, Pawel R. Kiela, Qing-Yu Zhang, Eileen White, Xinxin Ding, Aikseng Ooi, Donna D. Zhang
Publikováno v:
Molecular Metabolism, Vol 51, Iss , Pp 101243- (2021)
Objective: NRF2, a transcription factor that regulates cellular redox and metabolic homeostasis, plays a dual role in human disease. While it is well known that canonical intermittent NRF2 activation protects against diabetes-induced tissue damage, l
Externí odkaz:
https://doaj.org/article/9b6867c4cff24e0b97a6adf722e6305c
Autor:
Pengfei Liu, Gang Luo, Matthew Dodson, Cody J. Schmidlin, Yongyi Wei, Baris Kerimoglu, Aikseng Ooi, Eli Chapman, Joe GN. Garcia, Donna D. Zhang
Publikováno v:
Redox Biology, Vol 38, Iss , Pp 101766- (2021)
Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible disease characterized by an increase in differentiation of fibroblasts to myofibroblasts and excessive accumulation of extracellular matrix in lung tissue. Pharmacological activati
Externí odkaz:
https://doaj.org/article/effa802854e740848688058352c9fc25
Renal cell carcinomas associated with hereditary leiomyomatosis and renal cell cancer (HLRCC) are notoriously aggressive and represent the leading cause of death among patients with HLRCC. To date, a safe and effective standardized therapy for this t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025984a92fbbcbc944174ce08ea728dc
https://doi.org/10.1158/1535-7163.c.6543237
https://doi.org/10.1158/1535-7163.c.6543237
Supplementary Table from Cyst(e)inase–Rapamycin Combination Induces Ferroptosis in Both In Vitro and In Vivo Models of Hereditary Leiomyomatosis and Renal Cell Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8888de1c7ead926cd5b87219b12c73
https://doi.org/10.1158/1535-7163.22521957.v1
https://doi.org/10.1158/1535-7163.22521957.v1
Supplementary Data from Cyst(e)inase–Rapamycin Combination Induces Ferroptosis in Both In Vitro and In Vivo Models of Hereditary Leiomyomatosis and Renal Cell Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449834fee119da49c0700da4e204eef0
https://doi.org/10.1158/1535-7163.22521963
https://doi.org/10.1158/1535-7163.22521963