Výsledky vyhledávání

Inhibitory Effects of Rolipram on Partially Purified Phosphodiesterase 4 From Rat Brains

Autor: Miki Yamauchi, Shoichi Murakami, Jun Baba, Aiko Sawa, Fukuichi Ohsawa, Hiroshi Nagaso

Publikováno v: Japanese Journal of Pharmacology. 77:147-154

Several previous studies have demonstrated that the phosphodiesterase 4 selective inhibitor rolipram affects cellular function at a much lower concentration than the reported Ki value for phosphodiesterase 4 inhibition. In this study, we examined the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930073595b7a13a6dde390fbaa28084e
https://doi.org/10.1254/jjp.77.147

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Phosphodiesterase type 4 that regulates cAMP level in cortical neurons shows high sensitivity to rolipram

Autor: Jun Baba, Aiko Sawa, Nobuyuki Yamashita, Miki Yamauchi

Publikováno v: European Journal of Pharmacology. 337:95-102

To characterize the role of phosphodiesterase type 4 (a cAMP-specific and rolipram-sensitive phosphodiesterase) among phosphodiesterases in the regulation of the intracellular cAMP level in cortical neurons, we investigated the effects of phosphodies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f19ca8ff19616a2459f4973d8da11a
https://doi.org/10.1016/s0014-2999(97)01285-5

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Neither the 5-HT1A- nor the 5-HT2-Receptor Subtype Mediates the Effect of Fluvoxamine, a Selective Serotonin Reuptake Inhibitor, on Forced-Swimming-Induced Immobility in Mice

Autor: Aiko Sawa, Takashi Egawa, Yasuyuki Ichimaru, Taiichiro Imanishi

Publikováno v: Japanese Journal of Pharmacology. 68:71-75

The effect of fluvoxamine, a selective serotonin (5-HT) reuptake inhibitor, was studied in the forced-swimming test, a model of depression, in mice. Fluvoxamine at 60 mg/kg, p.o. significantly decreased the immobility time in the forced-swimming test

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36baed8a53005ad76b002208741ceb5
https://doi.org/10.1254/jjp.68.71

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Ameliorating effects of rolipram on experimentally induced impairments of learning and memory in rodents

Autor: Tsuneyuki Yamamoto, Showa Ueki, Mio Miyashiro, Taiichiro Imanishi, Aiko Sawa, Yasuyuki Ichimaru, Shinsuke Kato

Publikováno v: European journal of pharmacology. 321(3)

The effects of rolipram, a cAMP-specific phosphodiesterase (phosphodiesterase 4) inhibitor, on experimentally-induced amnesia were examined using a 3-panel runway paradigm in rats and a passive avoidance task in mice. Scopolamine, cerebral ischemia i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059d92e5ad3b9baa415ffe4800f222e7
https://pubmed.ncbi.nlm.nih.gov/9085037

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Acetylcholine: oscillation of levels in mouse brain following electroshock

Autor: Susan T. Weintraub, William B. Stavinoha, Aiko Sawa, James W. Frazer

Publikováno v: Brain research bulletin. 43(1)

The acetylcholine contents of mouse brain regions were measured in order to investigate the response of cholinergic neurons to electroshock. In this study, mice were subjected to electroshock and then sacrificed by microwave irradiation at time inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310648c1dcf582c032292ea38bf26ee8
https://pubmed.ncbi.nlm.nih.gov/9205794

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5-HT1A-receptor subtype mediates the effect of fluvoxamine, a selective serotonin reuptake inhibitor, on marble-burying behavior in mice

Autor: Takashi Egawa, Yasuyuki Ichimaru, Aiko Sawa

Publikováno v: Japanese journal of pharmacology. 68(1)

The effect of fluvoxamine, a selective serotonin (5-HT) reuptake inhibitor, was studied in a model of anxiety and/or obsessive compulsive disorder (OCD) in mice. In the anxiety/OCD model, marble-burying behavior, marble-burying was significantly supp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af626e284af0173c9747bc2b9104b294
https://pubmed.ncbi.nlm.nih.gov/7494384

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