Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Aiko Nitta"'
Autor:
Masato Nose, Aiko Nitta, Yundi Zheng, Rihoko Kizukuri, Yuki Nagao, Shigenori Nagai, Mamoru Aizawa
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10567 (2024)
Recent research has focused on immunotherapy with no side effects as an innovative medical treatment for cancer. However, typical drugs for immunotherapy are very expensive. Here, we propose the use of immunoceramics that activate immune cells by con
Externí odkaz:
https://doaj.org/article/d4771b24c4fb4aaabd86b94b315ff57e
Autor:
Yumiko Sekiya, Satoshi Sakami, Hiroki Kumagai, Takehiro Takahashi, Koji Kawai, Aiko Nitta, Seiji Okazaki, Tomokatsu Iwamura, Mikiya Sato, Mai Yagi, Junko Nakaki, Mie Kainoh
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 351:181-189
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is considered a potential therapeutic target in the treatment of type 2 diabetes mellitus. In this study, we investigated the pharmacological properties of HIS-388 (N-[(1R,2s,3S,5s,7s)-5-hydroxyada
Autor:
Koji Kawai, Mie Kaino, Takahiro Arai, Shuji Udagawa, Takehiro Takahashi, Aiko Nitta, Takahiro Takemura, Satoshi Sakami, Seiji Okazaki, Takumi Aoki, Tomokatsu Iwamura, Mikiya Sato
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1617-1621
A series of novel 5-trans-hydroxyadamantan-2-yl-5,6,7,8-tetrahydropyrazolo[4,3-c]azepin-4(1H)-ones that inhibit 11beta-hydroxysteroid dehydrogenase type 1 are described. We discovered these 7-membered cyclic amide derivatives by introducing a distinc
Autor:
Shiho Satoh, Junko Nakaki, Hideaki Fujii, Hiroki Kumagai, Aiko Nitta, Satoshi Sakami, Mikiya Satoh, Hideki Kawai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7036-7040
A series of novel 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides were investigated as dipeptidyl peptidase IV (DPP-4) inhibitors. Introduction of a 4-phenylthiazol-2-yl group showed highly potent DPP-4 inhibitory activity. Among various derivative
Autor:
Takayuki Imaoka, Shin-ichi Tsukamoto, Tatsuaki Morokata, Ippei Sato, Makoto Takeuchi, Toshiya Takahashi, Yosuke Iura, Hideki Inoue, Mitsuaki Ohta, Hirokazu Kubota, Aiko Nitta, Koichiro Morihira
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6876-6881
Optimization starting with our lead compound 1 (IC(50)=4.9 nM) led to the identification of pyrrolidinyl phenylurea derivatives. Further modification toward improvement of the bioavailability provided (R)-1-(1-((6-fluoronaphthalen-2-yl)methyl)pyrroli
Autor:
Shin-ichi Tsukamoto, Makoto Takeuchi, Toshiya Takahashi, Yosuke Iura, Mitsuaki Ohta, Koichiro Morihira, Ippei Sato, Takayuki Imaoka, Aiko Nitta, Tatsuaki Morokata, Hirokazu Kubota, Hiroki Tomioka
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4951-4954
The synthesis and structure–activity relationships of ureas as CCR3 antagonists are described. Optimization starting with lead compound 2 (IC50 = 190 nM) derived from initial screening hit compound 1 (IC50 = 600 nM) led to the identification of (S)
Autor:
Shinichi Yamaguchi, Kazuharu Suyama, Kazumi Nishimura, Hiroshi Ueda, Yosuke Iura, Masateru Yamada, Toshiya Takahashi, Shigeo Fujii, Nobuhiro Fuchi, Aiko Nitta, Hiroaki Kaneko, Yumiko Sekiya
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4358-4361
We report the discovery and structure–activity relationship of 2,6-disubstituted pyrazines, which are potent and selective CK2 inhibitors. Lead compound 1 was identified, and derivatives were prepared to develop potent inhibitory activity. As a res
Autor:
Hiroki Kumagai, Yutaka Nishimura, Chifumi Inada, Hideaki Fujii, Aiko Nitta, Shiho Satoh, Junko Nakaki, Tomofumi Ohyama, Mikiya Satoh, Hideki Kozono, Masahiro Shimamura, Satoshi Sakami, Tominaga Fukazawa, Hideki Kawai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5435-5438
Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides and 3-amino-N-(4-aryltetrahydropyran-4-yl)butanamides were synthesized and evaluated as dipeptidyl peptidase IV (DPP-IV) inhibitors. Derivatives incorporating the 6-substituted benzoth
Publikováno v:
ChemInform. 28
Publikováno v:
ChemInform. 30