Phosphorylation of Threonine 3: IMPLICATIONS FOR HUNTINGTIN AGGREGATION AND NEUROTOXICITY*

Autor: Aiken, CT, Steffan, JS, Guerrero, CM, Khashwji, H, Lukacsovich, T, Simmons, D, Purcell, JM, Menhaji, K, Zhu, YZ, Green, K, LaFerla, F, Huang, L, Thompson, LM, Marsh, JL

Publikováno v: Aiken, CT; Steffan, JS; Guerrero, CM; Khashwji, H; Lukacsovich, T; Simmons, D; et al.(2009). Phosphorylation of threonine 3: Implications for huntingtin aggregation and neurotoxicity. Journal of Biological Chemistry, 284(43), 29427-29436. doi: 10.1074/jbc.M109.013193. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/71k9t5m4

Huntingtin (Htt) is a widely expressed protein that causes tissue-specific degeneration when mutated to contain an expanded polyglutamine (poly(Q)) domain. Although Htt is large, 350 kDa, the appearance of amino-terminal fragments of Htt in extracts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::50cea231d34ee0d0472afd737a3a750d
https://europepmc.org/articles/PMC2785575/

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IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.

Autor: Thompson LM; Department of Psychiatry and Human Behavior, University of California, Irvine, 92697, USA., Aiken CT, Kaltenbach LS, Agrawal N, Illes K, Khoshnan A, Martinez-Vincente M, Arrasate M, O'Rourke JG, Khashwji H, Lukacsovich T, Zhu YZ, Lau AL, Massey A, Hayden MR, Zeitlin SO, Finkbeiner S, Green KN, LaFerla FM, Bates G, Huang L, Patterson PH, Lo DC, Cuervo AM, Marsh JL, Steffan JS

Publikováno v: The Journal of cell biology [J Cell Biol] 2009 Dec 28; Vol. 187 (7), pp. 1083-99. Date of Electronic Publication: 2009 Dec 21.