Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Aikaterini S. Papadopoulou"'
Autor:
Casandra Gomez-Paredes, Michael A. Mason, Bridget A. Taxy, Aikaterini S. Papadopoulou, Paolo Paganetti, Gillian P. Bates
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Huntington’s disease (HD) is a devastating neurodegenerative disorder, caused by a CAG/polyglutamine repeat expansion, that results in the aggregation of the huntingtin protein, culminating in the deposition of inclusion bodies in HD patie
Externí odkaz:
https://doaj.org/article/c4d49ced2d0743ada535353ffd2d0f3e
Autor:
Yassine Sassi, Petros Avramopoulos, Deepak Ramanujam, Laurenz Grüter, Stanislas Werfel, Simon Giosele, Andreas-David Brunner, Dena Esfandyari, Aikaterini S. Papadopoulou, Bart De Strooper, Norbert Hübner, Regalla Kumarswamy, Thomas Thum, Xiaoke Yin, Manuel Mayr, Bernhard Laggerbauer, Stefan Engelhardt
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
MicroRNA-29 is known to reduce collagen production in fibroblasts thereby inhibiting fibrosis in various organs. Here, Sassi et al. show that miR-29 can also enhance fibrotic signalling and pathological hypertrophy of the heart through its action in
Externí odkaz:
https://doaj.org/article/c77feaa169934783a5813a2d5609a475
Autor:
Aikaterini S. Papadopoulou, Lutgarde Serneels, Tilmann Achsel, Wim Mandemakers, Zsuzsanna Callaerts-Vegh, James Dooley, Pierre Lau, Torik Ayoubi, Enrico Radaelli, Marco Spinazzi, Melanie Neumann, Sébastien S. Hébert, Asli Silahtaroglu, Adrian Liston, Rudi D'Hooge, Markus Glatzel, Bart De Strooper
Publikováno v:
Neurobiology of Disease, Vol 73, Iss , Pp 275-288 (2015)
miR-29 is expressed strongly in the brain and alterations in expression have been linked to several neurological disorders. To further explore the function of this miRNA in the brain, we generated miR-29a/b-1 knockout animals. Knockout mice develop a
Externí odkaz:
https://doaj.org/article/4cfe1d691b9748729b660c08f5ce439c
Autor:
Sébastien S. Hébert, Katrien Horré, Laura Nicolaï, Bruno Bergmans, Aikaterini S. Papadopoulou, André Delacourte, Bart De Strooper
Publikováno v:
Neurobiology of Disease, Vol 33, Iss 3, Pp 422-428 (2009)
Gene dosage effects of Amyloid precursor protein (APP) can cause familial AD. Recent evidence suggest that microRNA (miRNA) pathways, implicated in gene transcriptional control, could be involved in the development of sporadic Alzheimer's disease (AD
Externí odkaz:
https://doaj.org/article/288cc7fcb7f54b1c8aec3d444fe18bfa
Autor:
Paolo Paganetti, Bridget A. Taxy, Casandra Gomez-Paredes, Aikaterini S. Papadopoulou, Gillian P. Bates, Michael A Mason
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Huntington’s disease (HD) is a devastating neurodegenerative disorder, caused by a CAG/polyglutamine repeat expansion, that results in the aggregation of the huntingtin protein, culminating in the deposition of inclusion bodies in HD patient brains
Autor:
Gillian P. Bates, Aikaterini S. Papadopoulou, Bridget A. Taxy, David Howland, Casandra Gomez-Paredes, Michael A Mason
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by a CAG repeat expansion within exon 1 of the huntingtin (HTT) gene. HTT mRNA contains 67 exons and does not always splice between exon 1 and exon 2 leading to the product
Autor:
Sean J McAteer, Aikaterini S. Papadopoulou, Michael A Mason, Casandra Gomez Paredes, Gillian P. Bates
Publikováno v:
Pathogenic mechanisms.
Background The heat shock response (HSR) is responsible for the maintenance of proteome integrity within cells. HSR is induced under conditions of proteotoxic stress such as the presence of aggregates or aberrantly-folded proteins, as observed in Hun
Autor:
Laila Blomer, Aikaterini S. Papadopoulou, Edward J Smith, Gillian P. Bates, Christian Landles, Kirupa Sathasivam, Sandra K Fienko
Publikováno v:
Models for HD.
Background Huntington’s Disease (HD) is an inherited neurodegenerative disorder caused by the expansion of a CAG repeat in the HTT gene. We have recently shown that incomplete splicing of HTT mRNA, in both HD patients and mouse models, produces a H
Publikováno v:
Pathogenic mechanisms.
Background Huntington’s disease (HD) is caused by an expanded CAG repeat in exon 1 of the HTT gene. In models of HD, an expanded CAG repeat in HTT causes premature termination of HTT RNA during transcription; this occurs by a process called incompl
Autor:
Casandra Gomez-Paredes, Gillian P. Bates, Michael A Mason, Emily C E Danby, Aikaterini S. Papadopoulou
Publikováno v:
Wet biomarkers.
Background Huntington’s Disease (HD) is neurodegenerative disorder caused by the expansion of a CAG repeat in the HTT gene. We have recently shown that incomplete splicing of exon 1 to exon 2 of the HTT (human) and Htt (mouse) mRNAs produces a poly