Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Aikaterini Chatzipli"'
Autor:
Umberto Perron, Elena Grassi, Aikaterini Chatzipli, Marco Viviani, Emre Karakoc, Lucia Trastulla, Lorenzo M. Brochier, Claudio Isella, Eugenia R. Zanella, Hagen Klett, Ivan Molineris, Julia Schueler, Manel Esteller, Enzo Medico, Nathalie Conte, Ultan McDermott, Livio Trusolino, Andrea Bertotti, Francesco Iorio
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Patient-derived xenografts (PDXs) are tumour fragments engrafted into mice for preclinical studies. PDXs offer clear advantages over simpler in vitro cancer models - such as cancer cell lines (CCLs) and organoids - in terms of structural com
Externí odkaz:
https://doaj.org/article/e3eb9c07dbae4f8bbe9a18205016643b
Autor:
Enric Domingo, Sanjay Rathee, Andrew Blake, Leslie Samuel, Graeme Murray, David Sebag-Montefiore, Simon Gollins, Nicholas West, Rubina Begum, Susan Richman, Phil Quirke, Keara Redmond, Aikaterini Chatzipli, Alessandro Barberis, Sylvana Hassanieh, Umair Mahmood, Michael Youdell, Ultan McDermott, Viktor Koelzer, Simon Leedham, Ian Tomlinson, Philip Dunne, Francesca M. Buffa, Timothy S. Maughan, Francesca Buffa, Geoffrey Higgins, Christopher Holmes, Timothy Maughan, Gillies McKenna, James Robineau, Philip Quirke, Matthew Seymour, Richard Kennedy, Mark Lawler, Manuel Salto-Tellez, Peter Campbell, Claire Hardy, Simon Bach, Andrew Beggs, Jean-Baptiste Cazier, Gary Middleton, Dion Morton, Celina Whalley, Louise Brown, Richard Kaplan, Richard Wilson, Richard Adams, Richard Sullivan, Paul Harkin, Steven Walker, Jim Hill, Chieh-Hsi Wu, Dennis Horgan
Publikováno v:
EBioMedicine, Vol 106, Iss , Pp 105228- (2024)
Summary: Background: It is uncertain which biological features underpin the response of rectal cancer (RC) to radiotherapy. No biomarker is currently in clinical use to select patients for treatment modifications. Methods: We identified two cohorts o
Externí odkaz:
https://doaj.org/article/6732596b11c54a618ebd9beb8dd8725c
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Bayesian network inference on several blood and solid cancer genomic datasets provides more accessible ways to explore driver events in cancer.
Externí odkaz:
https://doaj.org/article/9cd6211b053c4064aaf9b1e2c3b20d65
Autor:
Isidro, Cortes-Ciriano, Christopher D, Steele, Katherine, Piculell, Alyaa, Al-Ibraheemi, Vanessa, Eulo, Marilyn M, Bui, Aikaterini, Chatzipli, Brendan C, Dickson, Dana C, Borcherding, Andrew, Feber, Alon, Galor, Jesse, Hart, Kevin B, Jones, Justin T, Jordan, Raymond H, Kim, Daniel, Lindsay, Colin, Miller, Yoshihiro, Nishida, Paula Z, Proszek, Jonathan, Serrano, R Taylor, Sundby, Jeffrey J, Szymanski, Nicole J, Ullrich, David, Viskochil, Xia, Wang, Matija, Snuderl, Peter J, Park, Adrienne M, Flanagan, Angela C, Hirbe, Nischalan, Pillay, David T, Miller
Publikováno v:
Cancer Discovery. 13:654-671
Malignant peripheral nerve sheath tumor (MPNST), an aggressive soft-tissue sarcoma, occurs in people with neurofibromatosis type 1 (NF1) and sporadically. Whole-genome and multiregional exome sequencing, transcriptomic, and methylation profiling of 9
Autor:
David T. Miller, Nischalan Pillay, Angela C. Hirbe, Adrienne M. Flanagan, Peter J. Park, Matija Snuderl, Xia Wang, David Viskochil, Nicole J. Ullrich, Jeffrey J. Szymanski, R. Taylor Sundby, Jonathan Serrano, Paula Z. Proszek, Yoshihiro Nishida, Colin Miller, Daniel Lindsay, Raymond H. Kim, Justin T. Jordan, Kevin B. Jones, Jesse Hart, Alon Galor, Andrew Feber, Dana C. Borcherding, Brendan C. Dickson, Aikaterini Chatzipli, Marilyn M. Bui, Vanessa Eulo, Alyaa Al-Ibraheemi, Katherine Piculell, Christopher D. Steele, Isidro Cortes-Ciriano
Supplementary Table 1 includes the metadata on all subjects, including basic demographics and medical history. Supplementary Table 2 provides statistics on chrom 8 gene expression among tumors with H3K27me3 loss. Note: no changes have been made to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15deb6bdcb75389ac6ff3546033511c4
https://doi.org/10.1158/2159-8290.22542118.v1
https://doi.org/10.1158/2159-8290.22542118.v1
Autor:
David T. Miller, Nischalan Pillay, Angela C. Hirbe, Adrienne M. Flanagan, Peter J. Park, Matija Snuderl, Xia Wang, David Viskochil, Nicole J. Ullrich, Jeffrey J. Szymanski, R. Taylor Sundby, Jonathan Serrano, Paula Z. Proszek, Yoshihiro Nishida, Colin Miller, Daniel Lindsay, Raymond H. Kim, Justin T. Jordan, Kevin B. Jones, Jesse Hart, Alon Galor, Andrew Feber, Dana C. Borcherding, Brendan C. Dickson, Aikaterini Chatzipli, Marilyn M. Bui, Vanessa Eulo, Alyaa Al-Ibraheemi, Katherine Piculell, Christopher D. Steele, Isidro Cortes-Ciriano
Supplementary figures provide additional details on the genomic landscape of MPNST and interesting cases within the cohort.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161b5a8bac5dc55c121b8f13371bedb4
https://doi.org/10.1158/2159-8290.22542121
https://doi.org/10.1158/2159-8290.22542121
Autor:
David T. Miller, Nischalan Pillay, Angela C. Hirbe, Adrienne M. Flanagan, Peter J. Park, Matija Snuderl, Xia Wang, David Viskochil, Nicole J. Ullrich, Jeffrey J. Szymanski, R. Taylor Sundby, Jonathan Serrano, Paula Z. Proszek, Yoshihiro Nishida, Colin Miller, Daniel Lindsay, Raymond H. Kim, Justin T. Jordan, Kevin B. Jones, Jesse Hart, Alon Galor, Andrew Feber, Dana C. Borcherding, Brendan C. Dickson, Aikaterini Chatzipli, Marilyn M. Bui, Vanessa Eulo, Alyaa Al-Ibraheemi, Katherine Piculell, Christopher D. Steele, Isidro Cortes-Ciriano
Malignant peripheral nerve sheath tumor (MPNST), an aggressive soft-tissue sarcoma, occurs in people with neurofibromatosis type 1 (NF1) and sporadically. Whole-genome and multiregional exome sequencing, transcriptomic, and methylation profiling of 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae70edd78830fc820d4ca5d1771d9b86
https://doi.org/10.1158/2159-8290.c.6549805.v1
https://doi.org/10.1158/2159-8290.c.6549805.v1
Autor:
Simon S. McDade, Ultan McDermott, Daniel B. Longley, Mathew Garnett, Lodewyk Wessels, David A. Tice, Amy Wesa, Ido Sloma, Daniel Ciznadija, Syd Barthorpe, Aikaterini Chatzipli, Vivek Iyer, Magali Michaut, Lewis Gallagher, Jess Bateson, Jamie Young, Jochen Prehn, Katherine McAllister, Christopher McCann, Andrea Lees, Stacey Price, Nyree Crawford, Mark Wappett, Vera Grinkevitch
Multivalent second-generation TRAIL-R2 agonists are currently in late preclinical development and early clinical trials. Herein, we use a representative second-generation agent, MEDI3039, to address two major clinical challenges facing these agents:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2efa1fb2eca5731e15fb0928e1e7b7
https://doi.org/10.1158/1535-7163.c.6543438.v1
https://doi.org/10.1158/1535-7163.c.6543438.v1
Autor:
Simon S. McDade, Ultan McDermott, Daniel B. Longley, Mathew Garnett, Lodewyk Wessels, David A. Tice, Amy Wesa, Ido Sloma, Daniel Ciznadija, Syd Barthorpe, Aikaterini Chatzipli, Vivek Iyer, Magali Michaut, Lewis Gallagher, Jess Bateson, Jamie Young, Jochen Prehn, Katherine McAllister, Christopher McCann, Andrea Lees, Stacey Price, Nyree Crawford, Mark Wappett, Vera Grinkevitch
Supplementary Figure from Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6636bc7fd14949c096b587e72af567
https://doi.org/10.1158/1535-7163.22522569.v1
https://doi.org/10.1158/1535-7163.22522569.v1
Autor:
Simon S. McDade, Ultan McDermott, Daniel B. Longley, Mathew Garnett, Lodewyk Wessels, David A. Tice, Amy Wesa, Ido Sloma, Daniel Ciznadija, Syd Barthorpe, Aikaterini Chatzipli, Vivek Iyer, Magali Michaut, Lewis Gallagher, Jess Bateson, Jamie Young, Jochen Prehn, Katherine McAllister, Christopher McCann, Andrea Lees, Stacey Price, Nyree Crawford, Mark Wappett, Vera Grinkevitch
Supplementary Data from Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65e018c5371d1a9a5d2dd985a27fdf8
https://doi.org/10.1158/1535-7163.22522572.v1
https://doi.org/10.1158/1535-7163.22522572.v1